Featured Publications

Orphan quality control shapes network dynamics and gene expression.

Mark KG, Kolla S, Aguirre JD, Garshott DM, Schmitt S, Haakonsen DL, Xu C, Kater L, Kempf G, Martínez-González B, Akopian D, See SK, Thomä NH, Rapé M, 2023 Aug Cell 16 186 3460-3475.e23

Assembly and function of branched ubiquitin chains.

Kolla S, Ye M, Mark KG, Rapé M, 2022 Sep Trends Biochem Sci 9 47 759-771

Ubiquitin-dependent regulation of transcription in development and disease.

Mark KG, Rape M, 2021 Apr EMBO Rep 4 22 e51078

Gene expression and cell identity controlled by anaphase-promoting complex.

Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M, 2020 Mar Nature 7797 579 136-140

Monitoring SARS-CoV-2 incidence and seroconversion among university students and employees: a longitudinal cohort study in California, June-August 2020.

Hunter LA, Wyman S, Packel LJ, Facente SN, Li Y, Harte A, Nicolette G, Di Germanio C, Busch MP, Reingold AL, Petersen ML, 2023 Apr BMJ Open 4 13 e063999

Blueprint for a pop-up SARS-CoV-2 testing lab.

2020 Jul Nat Biotechnol 7 38 791-797

Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence.

Engström P, Burke TP, Mitchell G, Ingabire N, Mark KG, Golovkine G, Iavarone AT, Rape M, Cox JS, Welch MD, 2019 Dec Nat Microbiol 12 4 2538-2551

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T, 2018 Jun Nature 7709 558 313-317

Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps).

Mark KG, Loveless TB, Toczyski DP, 2016 Feb Nat Protoc 2 11 291-301

Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1.

Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP, 2015 Jul Biochemistry 29 54 4423-6

Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae.

Edenberg ER, Mark KG, Toczyski DP, 2015 Apr PLoS Genet 4 11 e1005162

Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins.

Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski DP, 2014 Jan Mol Cell 1 53 148-61

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT, 2013 Jun Proc Natl Acad Sci U S A 24 110 9932-7

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT, 2013 Jun Nat Chem Biol 6 9 398-405

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT, 2013 Apr ACS Chem Biol 4 8 812-22

Stat3 mediates expression of autotaxin in breast cancer.

Azare J, Doane A, Leslie K, Chang Q, Berishaj M, Nnoli J, Mark K, Al-Ahmadie H, Gerald W, Hassimi M, Viale A, Stracke M, Lyden D, Bromberg J, 2011 PLoS One 11 6 e27851

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.

Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF, 2007 Dec J Clin Invest 12 117 3846-56