McGinnis JH, Enriquez AB, Vandiver F, Bai X, Kim J, Kilgore J, Saha P, O'Hara R, Xie Y, Banaszynski LA, Williams N, McFadden DG. Endogenous EWSR1-FLI1 degron alleles enable control of fusion oncoprotein expression in tumor cell lines and xenografts. bioRxiv. 2024 Oct 29:2024.10.27.620498. doi: 10.1101/2024.10.27.620498. PMID:39554175
Frank AR, Vandiver F, McFadden G. Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors. ACS Chem Biol. 2024 Feb 16;19(2):471-482. doi: 10.1021/ascchembio.3c00663. Epub 2024 Jan 25. PMID:38270591
Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJB, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D. Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules. Cell Chem Biol. 2023 Nov 16;30(11):1453-1467.e8. doi:10.1016/j.chembiol.2023.07.017.Epub 2023 Aug 21. PMID:3760755
Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers L, Xie Y, Williams NS, Mishra P, McFadden DG. Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid. Cancer Discov. 2023 Aug 4;13(8):1884-1903. doi: 10.1158/2159-8290.CD-22-0982. PubMed PMID:37262072
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG. TK216 targets microtubules in Ewing sarcoma cells. Cell Chem Biol. 2022 Aug 18;29(8):1325-1332.e4. doi: 10.1016/j.chembiol.2022.06.002. Epub 2022 Jul 7. PubMed PMID: 35803262; PubMed Central PMCID: PMC9394687.
Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P. Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Nat Aging. 2022;2(2):155-169. doi: 10.1038/s43587-021-00164-x. Epub 2022 Jan 27. PubMed PMID: 35342888; PubMed Central PMCID: PMC8954567.
McFadden DG, Sadow PM. Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms. Front Endocrinol (Lausanne). 2021;12:696386. doi: 10.3389/fendo.2021.696386. eCollection 2021. Review. PubMed PMID: 34177816; PubMed Central PMCID: PMC8223676.
Tasdogan A, McFadden DG, Mishra P. Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer. Trends Cancer. 2020 Dec;6(12):1044-1058. doi: 10.1016/j.trecan.2020.08.004. Epub 2020 Sep 23. Review. PubMed PMID: 32980320.
Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice L, De Brabander JK, McFadden DG. A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins. J Med Chem. 2020 Nov 25;63(22):14054-14066. doi: 10.1021/acs.jmedchem.0c01482. Epub 2020 Nov 12. PubMed PMID: 33180487; PubMed Central PMCID: PMC7707623.
Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG. New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016. Epub 2020 Feb 1. Review. PubMed PMID: 32018053; PubMed Central PMCID: PMC7263769.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG. Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification. Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11. PubMed PMID: 31303577; PubMed Central PMCID: PMC6866228.
Ganly I, McFadden DG. Short Review: Genomic Alterations in Hürthle Cell Carcinoma. Thyroid. 2019 Apr;29(4):471-479. doi: 10.1089/thy.2019.0088. Review. PubMed PMID: 30848171.
Gopal RK, Kübler K, Calvo SE, Polak P, Livitz D, Rosebrock D, Sadow PM, Campbell B, Donovan SE, Amin S, Gigliotti BJ, Grabarek Z, Hess JM, Stewart C, Braunstein LZ, Arndt PF, Mordecai S, Shih AR, Chaves F, Zhan T, Lubitz CC, Kim J, Iafrate AJ, Wirth L, Parangi S, Leshchiner I, Daniels GH, Mootha VK, Dias-Santagata D, Getz G, McFadden DG. Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma. Cancer Cell. 2018 Aug 13;34(2):242-255.e5. doi: 10.1016/j.ccell.2018.06.013. PubMed PMID: 30107175; PubMed Central PMCID: PMC6121811.
Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016 Dec 3;388(10061):2783-2795. doi: 10.1016/S0140-6736(16)30172-6. Epub 2016 May 27. Review. PubMed PMID: 27240885.
McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H. Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proc Natl Acad Sci USA. 2016 Oct 18;113(42):E6409-E6417. doi: 10.1073/pnas.1613601113. Epub 2016 Oct 4. PubMed PMID: 27702896; PubMed Central PMCID: PMC5081629.
Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?. J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. PubMed PMID: 26829312; PubMed Central PMCID: PMC4836290.
Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol. 2015 Apr;10(4):553-64. doi: 10.1097/JTO.0000000000000459. PubMed PMID: 25675280; PubMed Central PMCID: PMC4523224.
Rothenberg SM, McFadden DG, Palmer EL, Daniels GH, Wirth LJ. Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenib. Clin Cancer Res. 2015 Mar 1;21(5):1028-35. doi: 10.1158/1078-0432.CCR-14-2915. Epub 2014 Dec 30. PubMed PMID: 25549723; NIHMSID:NIHMS708034.
McFadden DG, Dias-Santagata D, Sadow PM, Lynch KD, Lubitz C, Donovan SE, Zheng Z, Le L, Iafrate AJ, Daniels GH. Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2014 Nov;99(11):E2457-62. doi: 10.1210/jc.2014-2611. Epub 2014 Aug 22. PubMed PMID: 25148236; PubMed Central PMCID: PMC4223441.
Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell. 2014 Oct 23;159(3):676-90. doi: 10.1016/j.cell.2014.09.050. PubMed PMID: 25417114; PubMed Central PMCID: PMC4243044.
Vanden Borre P, Gunda V, McFadden DG, Sadow PM, Varmeh S, Bernasconi M, Parangi S. Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget. 2014 Jun 30;5(12):3996-4010. doi: 10.18632/oncotarget.2130. PubMed PMID: 24994118; PubMed Central PMCID: PMC4147301.
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci USA. 2014 Apr 22;111(16):E1600-9. doi: 10.1073/pnas.1404357111. Epub 2014 Apr 7. PubMed PMID: 24711431; PubMed Central PMCID: PMC4000830.
Vanden Borre P, McFadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S. The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma. Thyroid. 2014 Apr;24(4):705-14. doi: 10.1089/thy.2013.0483. Epub 2014 Jan 24. PubMed PMID: 24295207; PubMed Central PMCID: PMC3993062.
McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell. 2014 Mar 13;156(6):1298-1311. doi: 10.1016/j.cell.2014.02.031. PubMed PMID: 24630729; PubMed Central PMCID: PMC4040459.
McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201. doi: 10.1242/dev.01562. Epub 2004 Dec 2. PubMed PMID: 15576406.
Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM. Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15;255(2):230-7. doi: 10.1016/s0012-1606(02)00097-0. PubMed PMID: 12648486.
McFadden DG, McAnally J, Richardson JA, Charité J, Olson EN. Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development. 2002 Jul;129(13):3077-88. doi: 10.1242/dev.129.13.3077. PubMed PMID: 12070084.
McFadden DG, Olson EN. Heart development: learning from mistakes. Curr Opin Genet Dev. 2002 Jun;12(3):328-35. doi: 10.1016/s0959-437x(02)00306-4. Review. PubMed PMID: 12076677.
Charité J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN. Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. Genes Dev. 2001 Nov 15;15(22):3039-49. doi: 10.1101/gad.931701. PubMed PMID: 11711438; PubMed Central PMCID: PMC312822.
Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci USA. 2000 Dec 5;97(25):13655-60. doi: 10.1073/pnas.250485597. PubMed PMID: 11095750; PubMed Central PMCID: PMC17631.
McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development. 2000 Dec;127(24):5331-41. doi: 10.1242/dev.127.24.5331. PubMed PMID: 11076755; NIHMSID:NIHMS53272.
Charité J, McFadden DG, Olson EN. The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70. doi: 10.1242/dev.127.11.2461. PubMed PMID: 10804186.
Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70. doi: 10.1038/ng0398-266. PubMed PMID: 9500550; NIHMSID:NIHMS53275.