Publications

Featured Publications

A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence.

Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT, 2024 Jun Cell

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.

Jones BT, Han J, Zhang H, Hammer RE, Evers BM, Rakheja D, Acharya A, Mendell JT, 2023 Aug Genes Dev

NORAD-induced Pumilio phase separation is required for genome stability.

Elguindy MM, Mendell JT, 2021 Jun Nature

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT 2020 6523 370 eabc9546

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Kopp F, Elguindy MM, Yalvac ME, Zhang H, Chen B, Gillett FA, Lee S, Sivakumar S, Yu H, Xie Y, Mishra P, Sahenk Z, Mendell JT. 2019 eLife 8 e42650

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.

Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT 2017 Jan Nature

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.

Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT 2016 Jan Cell 1-2 164 69-80

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration.

Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Maitra A, Mendell JT 2014 May Cell 5 157 1104-16

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.

Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT 2009 Jun Cell 6 137 1005-17

c-Myc-regulated microRNAs modulate E2F1 expression.

O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT 2005 Jun Nature 7043 435 839-43

Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein.

Norris ML, Mendell JT, 2023 Mar Genes Dev 5-6 37 191-203

Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer.

Li X, Wang Y, Deng S, Zhu G, Wang C, Johnson NA, Zhang Z, Tirado CR, Xu Y, Metang LA, Gonzalez J, Mukherji A, Ye J, Yang Y, Peng W, Tang Y, Hofstad M, Xie Z, Yoon H, Chen L, Liu X, Chen S, Zhu H, Strand D, Liang H, Raj G, He HH, Mendell JT, Li B, Wang T, Mu P, 2023 Jul Cancer Cell

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication.

Rehfeld F, Eitson JL, Ohlson MB, Chang TC, Schoggins JW, Mendell JT, 2023 Jan Cell Rep 2 42 112076

RBM33 directs the nuclear export of transcripts containing GC-rich elements.

Thomas A, Rehfeld F, Zhang H, Chang TC, Goodarzi M, Gillet F, Mendell JT, 2022 May Genes Dev

MicroRNA turnover: a tale of tailing, trimming, and targets.

Han J, Mendell JT, 2022 Jul Trends Biochem Sci

eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.

Suresh S, Chen B, Zhu J, Golden RJ, Lu C, Evers BM, Novaresi N, Smith B, Zhan X, Schmid V, Jun S, Karacz CM, Peyton M, Zhong L, Wen Z, Sathe AA, Xing C, Behrens C, Wistuba II, Xiao G, Xie Y, Fu YX, Minna JD, Mendell JT, O'Donnell KA, 2020 May Nat Cancer 5 1 533-545

Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.

Zhang Z, Zhou C, Li X, Barnes SD, Deng S, Hoover E, Chen CC, Lee YS, Zhang Y, Wang C, Metang LA, Wu C, Tirado CR, Johnson NA, Wongvipat J, Navrazhina K, Cao Z, Choi D, Huang CH, Linton E, Chen X, Liang Y, Mason CE, de Stanchina E, Abida W, Lujambio A, Li S, Lowe SW, Mendell JT, Malladi VS, Sawyers CL, Mu P, 2020 Mar Cancer Cell

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine.

Trinh MN, Brown MS, Goldstein JL, Han J, Vale G, McDonald JG, Seemann J, Mendell JT, Lu F, 2020 Jul Proc. Natl. Acad. Sci. U.S.A.

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3' UTR-Directed Regulation and Nonsense-Mediated Decay.

Zhu X, Zhang H, Mendell JT, 2020 Jul Cell Rep 2 32 107895

Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination.

Lee JS, Mendell JT, 2020 03 Mol. Cell 5 77 1044-1054.e3

miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19.

Acharya A, Berry DC, Zhang H, Jiang Y, Jones BT, Hammer RE, Graff JM, Mendell JT, 2019 Sep Genes Dev.

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.

Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC, 2019 Apr Dev. Cell

Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection.

Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT, 2019 12 Cell Rep 10 29 3134-3146.e6

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD.

Elguindy MM, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang TC, Mendell JT, 2019 07 Elife 8

Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice.

Quirin KA, Kwon JJ, Alioufi A, Factora T, Temm CJ, Jacobsen M, Sandusky GE, Shontz K, Chicoine LG, Clark KR, Mendell JT, Korc M, Kota J 2018 Mar Mol Ther Methods Clin Dev 8 8-20

Functional Classification and Experimental Dissection of Long Noncoding RNAs.

Kopp F, Mendell JT 2018 Jan Cell 3 172 393-407

Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1

Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF. 2018 Genes Dev 32 996-1007

Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells

Hunter RW, Liu Y, Manjunath H, Acharya A, Jones BT, Zhang H, Chen B, Ramalingam H, Hammer RE, Xie Y, Richardson JA, Rakheja D, Carroll TJ, Mendell JT. 2018 Genes Dev 32 903-908

High-Throughput Characterization of Primary microRNA Transcripts.

Chang TC, Mendell JT 2018 Methods Mol. Biol. 1823 1-9

MicroRNA-29 overexpression by adeno-associated virus suppresses fibrosis and restores muscle function in combination with micro-dystrophin.

Heller KN, Mendell JT, Mendell JR, Rodino-Klapac LR 2017 May JCI Insight 9 2

Targeting a Long Noncoding RNA in Breast Cancer.

Mendell JT 2016 Jun N. Engl. J. Med. 23 374 2287-9

Transcriptional regulation of miR-31 by oncogenic KRAS mediates metastatic phenotypes by repressing RASA1.

Kent OA, Mendell JT, Rottapel R 2016 Jan Mol. Cancer Res.

Precise let-7 expression levels balance organ regeneration against tumor suppression.

Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H 2015 Oct Elife 4

Identification of miR-145 targets through an integrated omics analysis.

Huang TC, Renuse S, Pinto S, Kumar P, Yang Y, Chaerkady R, Godsey B, Mendell JT, Halushka MK, Civin CI, Marchionni L, Pandey A 2015 Jan Mol Biosyst 1 11 197-207

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads.

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL 2015 Feb Nat. Biotechnol.

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms.

Chang TC, Pertea M, Lee S, Salzberg SL, Mendell JT 2015 Aug Genome Res.

Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice.

Knabel MK, Ramachandran K, Karhadkar S, Hwang HW, Creamer TJ, Chivukula RR, Sheikh F, Clark KR, Torbenson M, Montgomery RA, Cameron AM, Mendell JT, Warren DS 2015 PLoS ONE 4 10 e0124411

PIPE-CLIP: a comprehensive online tool for CLIP-seq data analysis.

Chen B, Yun J, Kim MS, Mendell JT, Xie Y 2014 Jan Genome Biol. 1 15 R18

Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis.

Zeitels LR, Acharya A, Shi G, Chivukula D, Chivukula RR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Richardson JA, Mendell JT 2014 Dec Genes Dev. 23 28 2585-90

Seeing through the miRage of tissue complexity.

Shi G, Mendell JT 2014 Cell Cycle 19 13 2988-9

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF 2014 Nat Commun 2 4802

When 19 is greater than 92.

Zeitels LR, Mendell JT 2013 Elife 2 e01514

MicroRNAs in stress signaling and human disease.

Mendell JT, Olson EN 2012 Mar Cell 6 148 1172-87

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal K 2012 Aug J. Clin. Invest. 8 122 2871-83

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts.

Ribas J, Ni X, Castanares M, Liu MM, Esopi D, Yegnasubramanian S, Rodriguez R, Mendell JT, Lupold SE 2012 Aug Nucleic Acids Res. 14 40 6821-33

Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis.

Chaulk SG, Thede GL, Kent OA, Xu Z, Gesner EM, Veldhoen RA, Khanna SK, Goping IS, MacMillan AM, Mendell JT, Young HS, Fahlman RP, Glover JN 2011 Nov-Dec RNA Biol 6 8 1105-14

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation.

Lee YN, Brandal S, Noel P, Wentzel E, Mendell JT, McDevitt MA, Kapur R, Carter M, Metcalfe DD, Takemoto CM 2011 Mar Blood 13 117 3629-40

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice.

Pramanik D, Campbell NR, Karikari C, Chivukula R, Kent OA, Mendell JT, Maitra A 2011 Jul 1470-80

Identifying targets of miR-143 using a SILAC-based proteomic approach.

Yang Y, Chaerkady R, Kandasamy K, Huang TC, Selvan LD, Dwivedi SB, Kent OA, Mendell JT, Pandey A 2010 Oct Mol Biosyst 10 6 1873-82

Myc: Maestro of MicroRNAs.

Bui TV, Mendell JT 2010 Jun 6 1 568-575

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.

Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, Mendell JT 2010 Dec Genes Dev. 24 24 2754-9

Quantification of global microRNA abundance by selective isotachophoresis.

Persat A, Chivukula RR, Mendell JT, Santiago JG 2010 Dec Anal. Chem. 23 82 9631-5

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.

Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ 2010 Apr Proc. Natl. Acad. Sci. U.S.A. 14 107 6334-9

miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth.

Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi AH, Chowdhury WH, Kudrolli TA, Yegnasubramanian S, Luo J, Rodriguez R, Mendell JT, Lupold SE 2009 Sep Cancer Res. 18 69 7165-9

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.

Kent OA, Mullendore M, Wentzel EA, López-Romero P, Tan AC, Alvarez H, West K, Ochs MF, Hidalgo M, Arking DE, Maitra A, Mendell JT 2009 Nov Cancer Biol. Ther. 21 8 2013-24

Abate and switch: miR-145 in stem cell differentiation.

Chivukula RR, Mendell JT 2009 May Cell 4 137 606-8

Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach.

Yang Y, Chaerkady R, Beer MA, Mendell JT, Pandey A 2009 Mar Proteomics 5 9 1374-84

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.

Chang TC, Zeitels LR, Hwang HW, Chivukula RR, Wentzel EA, Dews M, Jung J, Gao P, Dang CV, Beer MA, Thomas-Tikhonenko A, Mendell JT 2009 Mar Proc. Natl. Acad. Sci. U.S.A. 9 106 3384-9

Tumors line up for a letdown.

Mendell JT 2009 Jul Nat. Genet. 7 41 768-9

MicroRNA miR-155 is a biomarker of early pancreatic neoplasia.

Habbe N, Koorstra JB, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, Hong SM, Maitra A 2009 Feb Cancer Biol. Ther. 4 8 340-6

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV 2009 Apr Nature 7239 458 762-5

Cell-cell contact globally activates microRNA biogenesis.

Hwang HW, Wentzel EA, Mendell JT 2009 Apr Proc. Natl. Acad. Sci. U.S.A. 17 106 7016-21

Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer.

Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT, Maitra A 2009 Pancreatology 3 9 293-301

Circular reasoning: microRNAs and cell-cycle control.

Chivukula RR, Mendell JT 2008 Oct Trends Biochem. Sci. 10 33 474-81

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.

Chung EY, Dews M, Cozma D, Yu D, Wentzel EA, Chang TC, Schelter JM, Cleary MA, Mendell JT, Thomas-Tikhonenko A 2008 Nov Cancer Biol. Ther. 11 7 1758-64

Analysis of regulatory network topology reveals functionally distinct classes of microRNAs.

Yu X, Lin J, Zack DJ, Mendell JT, Qian J 2008 Nov Nucleic Acids Res. 20 36 6494-503

Widespread microRNA repression by Myc contributes to tumorigenesis.

Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT 2008 Jan Nat. Genet. 1 40 43-50

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1.

Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ 2008 Feb Proc. Natl. Acad. Sci. U.S.A. 5 105 1516-21

Functional integration of microRNAs into oncogenic and tumor suppressor pathways.

Lotterman CD, Kent OA, Mendell JT 2008 Aug Cell Cycle 16 7 2493-9

miRiad roles for the miR-17-92 cluster in development and disease.

Mendell JT 2008 Apr Cell 2 133 217-22

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.

Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT 2007 Jun Mol. Cell 5 26 745-52

A hexanucleotide element directs microRNA nuclear import.

Hwang HW, Wentzel EA, Mendell JT 2007 Jan Science 5808 315 97-100

microRNAs in vertebrate physiology and human disease.

Chang TC, Mendell JT 2007 Annu Rev Genomics Hum Genet 8 215-39

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.

Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A 2006 Sep Nat. Genet. 9 38 1060-5

A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes.

Kent OA, Mendell JT 2006 Oct Oncogene 46 25 6188-96

MicroRNAs in cell proliferation, cell death, and tumorigenesis.

Hwang HW, Mendell JT 2006 Mar Br. J. Cancer 6 94 776-80

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.

Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T 2006 Jun Gastroenterology 7 130 2113-29

MicroRNAs: critical regulators of development, cellular physiology and malignancy.

Mendell JT 2005 Sep Cell Cycle 9 4 1179-84

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.

Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC 2004 Oct Nat. Genet. 10 36 1073-8

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts.

Mendell JT, ap Rhys CM, Dietz HC 2002 Oct Science 5592 298 419-22

When the message goes awry: disease-producing mutations that influence mRNA content and performance.

Mendell JT, Dietz HC 2001 Nov Cell 4 107 411-4

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability.

Medghalchi SM, Frischmeyer PA, Mendell JT, Kelly AG, Lawler AM, Dietz HC 2001 Jan Hum. Mol. Genet. 2 10 99-105

Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC 2000 Dec Mol. Cell. Biol. 23 20 8944-57

Novel compound heterozygous laminina2-chain gene (LAMA2) mutations in congenital muscular dystrophy. Mutations in brief no. 159. Online.

Mendell JT, Panicker SG, Tsao CY, Feng B, Sahenk Z, Marzluf GA, Mendell JR 1998 Hum. Mutat. 2 12 135