Publications

Featured Publications

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma.

Yi J, Kim B, Shi X, Zhan X, Lu QR, Xuan Z, Wu J, 2022 Jun Cancer Res

Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth.

Deng H, Guo X, Feng N, Luo Y, Liu B, Liu S, Wu JI, Shi X, 2022 Front Oncol 12 1057147

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation.

Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, Xuan Z, Wu J, 2021 Jul Cell Rep 2 36 109357

Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.

Yi J, Shi X, Xuan Z, Wu J, 2020 Nov Cancer Lett

A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors.

Zhang Z, Zhan X, Kim B, Wu J 2019 Feb J. Biol. Chem.

Epigenetic regulation in medulloblastoma.

Yi J, Wu J 2017 Dec Mol. Cell. Neurosci.

SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development.

Shi X, Wang Q, Gu J, Xuan Z, Wu JI 2016 Apr Oncogene

Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.

Petrik D, Latchney SE, Masiulis I, Yun S, Zhang Z, Wu JI, Eisch AJ 2015 Sep Stem Cells

Autism-Associated Chromatin Regulator Brg1/SmarcA4 is Required for Synapse Development and MEF2-mediated Synapse Remodeling.

Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber K, Wu JI 2015 Oct Mol. Cell. Biol.

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities.

Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI 2015 Jun Genesis

Camk2a-Cre-mediated conditional deletion of chromatin remodeler Brg1 causes perinatal hydrocephalus.

Cao M, Wu JI 2015 Jun Neurosci. Lett. 597 71-6

A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma.

Shi X, Zhan X, Wu J 2015 Oncogenesis 4 e176

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.

Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J 2014 Nat Commun 5 5425

Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer.

Wu JI 2012 Jan Acta Biochim. Biophys. Sin. (Shanghai) 1 44 54-69

Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development.

Zhan X, Shi X, Zhang Z, Chen Y, Wu JI 2011 Jul 12758-63

A Novel Oncogenic Function of PRC2 Heterogeneity in Medulloblastoma

Jiaqing Yi, Xuanming Shi, Xiaoming Zhan, Richard Q Lu, Zhenyu Xuan, Jiang Wu 2021 doi: https://doi.org/10.1101/2021.12.02.470979

Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.

Han Y, Wang B, Cho YS, Zhu J, Wu J, Chen Y, Jiang J, 2019 Jun Dev. Cell

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-?2 nuclear import system.

Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J 2017 Aug PLoS Biol. 8 15 e2002063

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.

Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M 2013 Oct Cell Stem Cell 4 13 403-18

The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA 2013 Mar Nat. Neurosci.

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.

Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR 2013 Jan Cell 1-2 152 248-61

NF-?B Forms a Complex with the Chromatin Remodeler BRG1 to Regulate Schwann Cell Differentiation.

Limpert AS, Bai S, Narayan M, Wu J, Yoon SO, Carter BD, Lu QR 2013 Feb J. Neurosci. 6 33 2388-2397

STAR trek: An introduction to STAR family proteins and review of quaking (QKI).

Artzt K, Wu JI 2010 Adv. Exp. Med. Biol. 693 1-24

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR 2009 Mar Proc. Natl. Acad. Sci. U.S.A. 13 106 5181-6

Understanding the words of chromatin regulation.

Wu JI, Lessard J, Crabtree GR 2009 Jan Cell 2 136 200-6

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.

Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP 2008 Feb Dev. Cell 2 14 298-311

Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury.

Wu JI, Centilli MA, Vasquez G, Young S, Scolnick J, Durfee LA, Spearow JL, Schwantz SD, Rennebeck G, Artzt K 2007 Oct Genetics 2 177 1151-61

Regulation of dendritic development by neuron-specific chromatin remodeling complexes.

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR, 2007 Oct Neuron 1 56 94-108

Targeted disruption of Mib2 causes exencephaly with a variable penetrance.

Wu JI, Rajendra R, Barsi JC, Durfee L, Benito E, Gao G, Kuruvilla M, Hrdlicková R, Liss AS, Artzt K 2007 Nov Genesis 11 45 722-7

Cell signaling. Nuclear actin as choreographer of cell morphology and transcription.

Wu JI, Crabtree GR, Crabtee GR 2007 Jun Science 5832 316 1710-1

An essential switch in subunit composition of a chromatin remodeling complex during neural development.

Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR, 2007 Jul Neuron 2 55 201-15

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.

Barsi JC, Rajendra R, Wu JI, Artzt K 2005 Oct Mech. Dev. 10 122 1106-17

A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.

Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K, Wong-Staal F 2002 Feb J. Biol. Chem. 8 277 5778-84

Function of quaking in myelination: regulation of alternative splicing.

Wu JI, Reed RB, Grabowski PJ, Artzt K 2002 Apr Proc. Natl. Acad. Sci. U.S.A. 7 99 4233-8

The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.

Wu J, Zhou L, Tonissen K, Tee R, Artzt K 1999 Oct J. Biol. Chem. 41 274 29202-10

T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.

Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC 1999 Jun Hum. Mol. Genet. 6 8 959-69

Genomic organization and expression analysis of the mouse qkI locus.

Kondo T, Furuta T, Mitsunaga K, Ebersole TA, Shichiri M, Wu J, Artzt K, Yamamura K, Abe K 1999 Jul Mamm. Genome 7 10 662-9