Publications for Jihan Osborne, Ph.D. | Osborne Lab

LIN28-mediated gene regulatory loops synchronize transitions throughout organogenesis.

Thevarajan I, Osuna MF, Lewey SF, Sauceda E, Briseno S, Griffin C, Kim B, Rowe RG, da Rocha EL, Osborne JK, 2025 Dec Biochem Biophys Rep 44 102226

Unexpected Differences in the Speed of Non-Malignant versus Malignant Cell Migration Reveal Differential Basal Intracellular ATP Levels.

Kim B, Lopez AT, Thevarajan I, Osuna MF, Mallavarapu M, Gao B, Osborne JK, 2023 Nov Cancers (Basel) 23 15

Lin28 paralogs regulate lung branching morphogenesis.

Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ, 2021 Jul Cell Rep 3 36 109408

Defining the First Part of the Oncogenic KRAS Journey.

Osborne JK, Minna JD, 2020 Oct Cell Stem Cell 4 27 499-500

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.

Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ, 2019 01 Nat Commun 1 10 168

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ, 2017 Jan Nat Cell Biol 1 19 60-67

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.

Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba II, Gazdar AF, Hayward NK, Minna JD, 2016 09 J Clin Invest 9 126 3219-35

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE, 2016 08 Cell Rep 5 16 1259-1272

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma.

Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ, 2016 07 Nature 7611 535 246-51

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.

Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH, 2014 Nov Oncogene 47 33 5457-66

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas.

Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH, 2014 Jun Mol Biol Cell 11 25 1782-92

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition.

Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH, 2013 Aug Oncogenesis 2 e63

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.

Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH, 2013 Apr Proc Natl Acad Sci U S A 16 110 6524-9

Signal control through Raf: in sickness and in health.

Osborne JK, Zaganjor E, Cobb MH, 2012 Jan Cell Res 1 22 14-22

A small molecule differentiation inducer increases insulin production by pancreatic ? cells.

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH, 2011 Dec Proc Natl Acad Sci U S A 51 108 20713-8

Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain.

Brazel CY, Limke TL, Osborne JK, Miura T, Cai J, Pevny L, Rao MS, 2005 Aug Aging Cell 4 4 197-207