TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, 2023 Jun J Clin Invest 11 133Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, 2023 Aug Elife 12Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, 2021 Sep JCI InsightMetabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, 2019 01 Nature 7737 565 96-100De novo NAD+ biosynthetic impairment in acute kidney injury in humans.
Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, 2018 09 Nat Med 9 24 1351-1359Tie2 protects the vasculature against thrombus formation in systemic inflammation.
Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, 2018 04 J Clin Invest 4 128 1471-1484PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM, 2016 Mar Nature 7595 531 528-32Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.
Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM, 2016 Mar Proc Natl Acad Sci U S A 9 113 2472-7Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, 2012 Jun Proc Natl Acad Sci U S A 25 109 10024-9PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice.
Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM, 2011 Oct J Clin Invest 10 121 4003-14Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial.
Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi MN, Chase M, Gong MN, Gong J, Parikh SM, Ngo L, Berlin N, Donnino MW, 2023 Jun Am J Respir Crit Care MedNAD+ precursor nutritional supplements sensitize the brain to future ischemic events.
Qu W, Ralto KM, Qin T, Cheng Y, Zong W, Luo X, Perez-Pinzon M, Parikh SM, Ayata C, 2023 Feb J Cereb Blood Flow Metab 271678X231156500Fostering Scientific Innovation to Impact AKI: A Roadmap from ASN's AKINow Basic Science Workgroup.
Parikh SM, Agarwal A, Bajwa A, Kumar S, Mansour SG, Okusa MD, Cerda J, 2022 Aug Kidney360 8 3 1445-1448Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
Schmaier AA, Hurtado GP, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Gerszten RE, Yu XG, Peters K, Flaumenhaft R, Parikh SM, 2021 May medRxivSkimming the fat in diabetic kidney disease: KIM-1 and tubular fatty acid uptake.
Huang H, Parikh SM, 2021 Jul Kidney IntTargeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1a.
Clark AJ, Parikh SM, 2021 04 Kidney Int 4 99 828-840Role of endothelial microRNA 155 on capillary leakage in systemic inflammation.
Etzrodt V, Idowu TO, Schenk H, Seeliger B, Prasse A, Thamm K, Pape T, Müller-Deile J, van Meurs M, Thum T, Garg A, Geffers R, Stahl K, Parikh SM, Haller H, David S, 2021 02 Crit Care 1 25 76Mitochondrial transplantation by intra-arterial injection for acute kidney injury.
Doulamis IP, Guariento A, Duignan T, Kido T, Orfany A, Saeed MY, Weixler VH, Blitzer D, Shin B, Snay ER, Inkster JA, Packard AB, Zurakowski D, Rousselle T, Bajwa A, Parikh SM, Stillman IE, Del Nido PJ, McCully JD, 2020 09 Am J Physiol Renal Physiol 3 319 F403-F413TFEB-driven lysosomal biogenesis is pivotal for PGC1?a??-dependent renal stress resistance.
Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM, 2020 08 JCI Insight 15 5Neutrophil activation in systemic capillary leak syndrome (Clarkson disease).
Xie Z, Kuhns DB, Gu X, Otu HH, Libermann TA, Gallin JI, Parikh SM, Druey KM, 2019 08 J Cell Mol Med 8 23 5119-5127TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance.
Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM, 2019 03 JCI Insight 5Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis.
Allegretti AS, Vela Parada X, Ortiz GA, Long J, Krinsky S, Zhao S, Fuchs BC, Sojoodi M, Zhang D, Karumanchi SA, Kalim S, Nigwekar SU, Thadhani RI, Parikh SM, Chung RT, 2019 02 Hepatology 2 69 729-741Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.
Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R, 2019 01 Lab Invest 1 99 138-145Increased synthesis of a coenzyme linked to longevity can combat disease.
Parikh SM, 2018 11 Nature 7731 563 332-333Renal PGC1a May Be Associated with Recovery after Delayed Graft Function.
Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM, 2018 Nephron 4 138 303-309Idiopathic systemic capillary leak syndrome (Clarkson disease).
Druey KM, Parikh SM, 2017 Sep J Allergy Clin Immunol 3 140 663-670The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation.
Parikh SM, 2017 Jul J Am Soc Nephrol 7 28 1973-1982Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis.
Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S, 2017 03 Sci Rep 7 44113KLF2 and KLF4 control endothelial identity and vascular integrity.
Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK, 2017 02 JCI Insight 4 2 e91700PPAR?-Coactivator-1a, Nicotinamide Adenine Dinucleotide and Renal Stress Resistance.
Poyan Mehr A, Parikh SM, 2017 Nephron 4 137 253-255Mitochondrial dysfunction in inherited renal disease and acute kidney injury.
Emma F, Montini G, Parikh SM, Salviati L, 2016 May Nat Rev Nephrol 5 12 267-80Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea.
Maski MR, Thomas RJ, Karumanchi SA, Parikh SM, 2016 PLoS One 5 11 e0154503Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.
Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R, 2015 Mar Blood 12 125 1976-85Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.
Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM, 2015 Jul Crit Care Med 7 43 e230-40Mitochondrial function and disturbances in the septic kidney.
Parikh SM, Yang Y, He L, Tang C, Zhan M, Dong Z, 2015 Jan Semin Nephrol 1 35 108-19The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation.
Milam KE, Parikh SM, 2015 Tissue Barriers 1-2 3 e957508Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense.
Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM, 2015 PLoS One 3 10 e0119577Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease.
Xie Z, Ghosh CC, Parikh SM, Druey KM, 2014 May Am J Respir Crit Care Med 9 189 1145-7Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease).
Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, Young M, Parikh SM, Druey KM, 2014 J Clin Cell Immunol 5 1000213Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury.
Parikh SM, 2013 Dec Curr Opin Crit Care 6 19 554-9Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS.
Parikh SM, 2013 Aug Virulence 6 4 517-24Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis.
David S, Kümpers P, van Slyke P, Parikh SM, 2013 Apr J Pharmacol Exp Ther 1 345 2-6Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*.
David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM, 2012 Nov Crit Care Med 11 40 3034-41Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.
David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM, 2011 Jun Am J Physiol Lung Cell Mol Physiol 6 300 L851-62The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis.
Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC, 2010 Crit Care 5 14 R182Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.
Yuan HT, Khankin EV, Karumanchi SA, Parikh SM, 2009 Apr Mol Cell Biol 8 29 2011-22Images in clinical medicine. Calcinosis associated with renal failure.
Cohen RA, Parikh SM, 2007 Dec N Engl J Med 25 357 2615Admission angiopoietin levels in children with septic shock.
Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS, 2007 Dec Shock 6 28 650-654Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP, 2007 Aug J Biol Chem 33 282 23910-8Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak.
Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP, 2007 Apr Clin Cancer Res 7 13 2115-20Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans.
Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP, 2006 Mar PLoS Med 3 3 e46The nature of the autonomic dysfunction in multiple system atrophy.
Parikh SM, Diedrich A, Biaggioni I, Robertson D, 2002 Aug J Neurol Sci 1-2 200 1-10