Featured Publications
TMEM16E regulates endothelial cell procoagulant activity and thrombosis.
Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S, 2023 Jun J Clin Invest 11 133Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM, 2023 Aug Elife 12Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu X, Peters KG, Flaumenhaft R, Parikh SM, 2021 Sep JCI InsightMetabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS, 2019 01 Nature 7737 565 96-100De novo NAD+ biosynthetic impairment in acute kidney injury in humans.
Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM, 2018 09 Nat Med 9 24 1351-1359Tie2 protects the vasculature against thrombus formation in systemic inflammation.
Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM, 2018 04 J Clin Invest 4 128 1471-1484PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM, 2016 Mar Nature 7595 531 528-32Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.
Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM, 2016 Mar Proc Natl Acad Sci U S A 9 113 2472-7Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM, 2012 Jun Proc Natl Acad Sci U S A 25 109 10024-9PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice.
Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM, 2011 Oct J Clin Invest 10 121 4003-14Increased synthesis of a coenzyme linked to longevity can combat disease.
Parikh SM, 2018 11 Nature 7731 563 332-333