Publications

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy.

Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL, 2023 Jan Sci Rep 1 13 18

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation.

Singh AK, Kumar R, Yin J, Brooks Ii JF, Kathania M, Mukherjee S, Kumar J, Conlon KP, Basrur V, Chen Z, Han X, Hooper LV, Burstein E, Venuprasad K, 2023 Aug Nat Commun 1 14 4972

Pak2-mediated phosphorylation promotes ROR?t ubiquitination and inhibits colonic inflammation.

Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K, 2022 Sep Cell Rep 11 40 111345

ROR?t protein modifications and IL-17-mediated inflammation.

Kumar R, Theiss AL, Venuprasad K, 2021 Nov Trends Immunol 11 42 1037-1050

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease.

Alula KM, Jackson DN, Smith AD, Kim DS, Turner K, Odstrcil E, Kaipparettu BA, Dassopoulos T, Venuprasad K, Feagins LA, Theiss AL, 2021 May Cells 6 10

Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.

Kumar R, Singh AK, Starokadomskyy P, Luo W, Theiss AL, Burstein E, Venuprasad K, 2021 Mar J Immunol 5 206 936-940

Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis.

Alula KM, Delgado-Deida Y, Jackson DN, Venuprasad K, Theiss AL, 2021 Jan Oncogene 2 40 369-383

Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function.

Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K, 2021 Jan J Immunother Cancer 1 9

NLRP6 in host defense and intestinal inflammation.

Venuprasad K, Theiss AL, 2021 Apr Cell Rep 4 35 109043

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.

Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K, 2020 Jun Nat. Immunol. 6 21 626-635

The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling.

Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL, 2020 Jul Cancer Res.

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.

Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL, 2020 Feb Gut

Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice.

Kathania M, Tsakem EL, Theiss AL, Venuprasad K, 2020 Apr J. Immunol. 8 204 2277-2284

Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.

Han J, Jackson D, Holm J, Turner K, Ashcraft P, Wang X, Cook B, Arning E, Genta RM, Venuprasad K, Souza RF, Sweetman L, Theiss AL 2018 Jan Proc. Natl. Acad. Sci. U.S.A. 5 115 1057-1062

SUMOylation of ROR-?t inhibits IL-17 expression and inflammation via HDAC2.

Singh AK, Khare P, Obaid A, Conlon KP, Basrur V, DePinho RA, Venuprasad K, 2018 10 Nat Commun 1 9 4515

IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.

Paul J, Singh AK, Kathania M, Elviche TL, Zeng M, Basrur V, Theiss AL, Venuprasad K, 2018 03 Mucosal Immunol 2 11 427-436

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-?t ubiquitination.

Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, Venuprasad K 2016 Jun Nat. Immunol.

The E3 ubiquitin ligase Itch inhibits p38a signaling and skin inflammation through the ubiquitylation of Tab1.

Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, Pascual V, Wei WZ, Massoumi R, Venuprasad K 2015 Feb Sci Signal 365 8 ra22

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K, 2011 Nov Nat. Immunol. 12 12 1176-83

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

Peng DJ, Zeng M, Muromoto R, Matsuda T, Shimoda K, Subramaniam M, Spelsberg TC, Wei WZ, Venuprasad K, 2011 May J. Immunol. 10 186 5638-47

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.

Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC, 2008 Mar Nat. Immunol. 3 9 245-53

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M, 2006 Feb Cell 3 124 601-13

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, Bloom D, Fathman CG, Liu YC, Penninger JM, 2004 Aug Immunity 2 21 167-77