Our Research
Cells rely on metabolism to generate the energy and molecular building blocks required for growth, differentiation, and survival. Metabolism is often taught as a series of biochemical reactions driven by random diffusion, yet it remains unclear how such seemingly stochastic processes can efficiently support complex cellular demands.
Our lab is interested in how cells actively organize metabolic pathways in space and time to meet changing physiological needs. We study how metabolic reactions are compartmentalized—from the level of enzymes to entire organelles—to regulate metabolic flux and cellular behavior.
Many metabolic pathways contain branch points where metabolites can be directed into competing reactions, but how cells control flux through these branch points is poorly understood. We investigate how metabolic enzymes are spatially organized within cells through higher-order assemblies and dynamic associations. By studying how enzyme organization influences pathway choice and metabolic efficiency, we aim to uncover fundamental mechanisms that allow cells to adapt metabolism to demand.
Organelles were traditionally viewed as isolated and static units, but growing evidence shows that they are highly dynamic and engage in constant communication with one another. We are interested in how organelle dynamics and inter-organelle interactions shape cellular metabolism. In particular, we ask whether all organelles are metabolically equivalent, whether distinct subpopulations exist, and how organelle heterogeneity influences metabolic pathway regulation and cellular function.
Our lab integrates techniques from cell biology, biochemistry, and metabolism, including:
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Super-resolution fluorescence microscopy and live-cell imaging
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Advanced electron microscopy (FIB-SEM and CLEM)
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Metabolomics and isotope tracing
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Biochemical reconstitution and enzyme assays
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Genomic and CRISPR-based perturbations
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Join Our Lab
We are looking for curious, independent, and collaborative researchers to become part of our group
We are seeking motivated postdoctoral researchers with backgrounds in biochemistry, cell biology, and metabolism. Candidates interested in developing new ideas within our research area are encouraged to apply. Please send a brief introduction and CV to: keunwoo.ryu@utsouthwestern.edu
We welcome graduate students who are motivated and enthusiastic about studying the exciting field of cellular metabolism. If you are interested in cell biology, organelle dynamics, and metabolism, please contact us or stop by our lab in NL7-110G.