Publications

​1. Fu, Y., Land, M., Kavlashvili, T., Cui, R., Kim, M., DeBitetto, E., Lieber, T., Ryu, K. W., Choi, E., Masilionis, I., Saha, R., Takizawa, M., Baker, D., Tigano, M., Lareau, C. A., Reznik, E., Sharma, R., Chaligne, R., Thompson, C. B., … Sfeir, A. (2025). Engineering mtDNA deletions by reconstituting end joining in human mitochondria. Cell, 188(10), 2778-2793.e21. https://doi.org/10.1016/j.cell.2025.02.009

2. Fung, T. S., Ryu, K. W., & Thompson, C. B. (2025). Arginine: At the crossroads of nitrogen metabolism. The EMBO Journal, 44(5), 1275–1293. https://doi.org/10.1038/s44318-025-00379-3

3. Ryu, K. W., Fung, T. S., Baker, D. C., Saoi, M., Park, J., Febres-Aldana, C. A., Aly, R. G., Cui, R., Sharma, A., Fu, Y., Jones, O. L., Cai, X., Pasolli, H. A., Cross, J. R., Rudin, C. M., & Thompson, C. B. (2024). Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature, 635(8039), 746–754. https://doi.org/10.1038/s41586-024-08146-w

4. Cai, X., Ng, C. P., Jones, O., Fung, T. S., Ryu, K. W., Li, D., & Thompson, C. B. (2023). Lactate activates the mitochondrial electron transport chain independently of its metabolism. Molecular Cell, 83(21), 3904-3920.e7. https://doi.org/10.1016/j.molcel.2023.09.034

5. Challa, S.*, Ryu, K. W.*, Whitaker, A. L., Abshier, J. C., Camacho, C. V., & Kraus, W. L. (2022). Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo. eLife, 11, e72464. https://doi.org/10.7554/eLife.72464

6. Challa, S., Khulpateea, B. R., Nandu, T., Camacho, C. V., Ryu, K. W., Chen, H., Peng, Y., Lea, J. S., & Kraus, W. L. (2021). Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Cell, 184(17), 4531-4546.e26. https://doi.org/10.1016/j.cell.2021.07.005

7. Zhu, J., Schwörer, S., Berisa, M., Kyung, Y. J., Ryu, K. W., Yi, J., Jiang, X., Cross, J. R., & Thompson, C. B. (2021). Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science, 372(6545), 968–972. https://doi.org/10.1126/science.abd5491

8. Huang, D., Camacho, C. V., Setlem, R., Ryu, K. W., Parameswaran, B., Gupta, R. K., & Kraus, W. L. (2020). Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Molecular Cell, 79(6), 934-949.e14. https://doi.org/10.1016/j.molcel.2020.08.002

9. Ryu, K. W., Nandu, T., Kim, J., Challa, S., DeBerardinis, R. J., & Kraus, W. L. (2018). Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis. Science, 360(6389), eaan5780. https://doi.org/10.1126/science.aan5780

10. Luo, X.*, Ryu, K. W.*, Kim, D.-S., Nandu, T., Medina, C. J., Gupte, R., Gibson, B. A., Soccio, R. E., Yu, Y., Gupta, R. K., & Kraus, W. L. (2017). PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular Cell, 65(2), 260–271. https://doi.org/10.1016/j.molcel.2016.11.015

11. Ryu, K. W., & Kraus, W. L. (2016). Who Put the “A” in ATP? Generation of ATP from ADP-Ribose in the Nucleus for Hormone-Dependent Gene Regulation. Molecular Cell, 63(3), 349–351. https://doi.org/10.1016/j.molcel.2016.07.018​

12. Kil, I. S., Ryu, K. W., Lee, S. K., Kim, J. Y., Chu, S. Y., Kim, J. H., Park, S., & Rhee, S. G. (2015). Circadian Oscillation of Sulfiredoxin in the Mitochondria. Molecular Cell, 59(4), 651–663. https://doi.org/10.1016/j.molcel.2015.06.031

13. Ryu, K. W., Kim, D.-S., & Kraus, W. L. (2015). New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases. Chemical Reviews, 115(6), 2453–2481. https://doi.org/10.1021/cr5004248

14. Kil, I. S., Lee, S. K., Ryu, K. W., Woo, H. A., Hu, M.-C., Bae, S. H., & Rhee, S. G. (2012). Feedback Control of Adrenal Steroidogenesis via H2O2-Dependent, Reversible Inactivation of Peroxiredoxin III in Mitochondria. Molecular Cell, 46(5), 584–594. https://doi.org/10.1016/j.molcel.2012.05.030

15. Zhang, T., Berrocal, J. G., Yao, J., DuMond, M. E., Krishnakumar, R., Ruhl, D. D., Ryu, K. W., Gamble, M. J., & Kraus, W. L. (2012). Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD+ Synthase. Journal of Biological Chemistry, 287(15), 12405–12416. https://doi.org/10.1074/jbc.M111.304469