Publications for Lorena Saelices, Ph.D.

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.

Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR, 2023 Mar bioRxiv

Disease-associated patterns of acetylation stabilize tau fibril formation.

Li L, Nguyen B, Mullapudi V, Saelices L, Joachimiak LA, 2023 Jan bioRxiv

Update on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis.

Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL, 2022 Aug Curr Heart Fail Rep

Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.

Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS, 2021 Sep Nat Struct Mol Biol 9 28 724-730

Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.

Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS, 2021 Mar bioRxiv

The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.

Cao Q, Anderson DH, Liang WY, Chou JA, Saelices L, 2020 Aug J. Biol. Chem.

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils.

Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS 2019 Feb J. Biol. Chem.

Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR.

Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS, 2018 12 Neurobiol. Dis. 120 118-125

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.

Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS, 2018 07 Proc. Natl. Acad. Sci. U.S.A. 29 115 E6741-E6750

Crystal structures of amyloidogenic segments of human transthyretin.

Saelices L, Sievers SA, Sawaya MR, Eisenberg DS, 2018 07 Protein Sci. 7 27 1295-1303

Common fibrillar spines of amyloid-? and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS, 2018 02 J. Biol. Chem. 8 293 2888-2902

Dissecting the Binding between Glutamine Synthetase and Its Two Natively Unfolded Protein Inhibitors.

Pantoja-Uceda D, Neira JL, Saelices L, Robles-Rengel R, Florencio FJ, Muro-Pastor MI, Santoro J, 2016 06 Biochemistry 24 55 3370-82

Uncovering the Mechanism of Aggregation of Human Transthyretin.

Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS 2015 Oct J. Biol. Chem.

A core of three amino acids at the carboxyl-terminal region of glutamine synthetase defines its regulation in cyanobacteria.

Saelices L, Robles-Rengel R, Florencio FJ, Muro-Pastor MI, 2015 May Mol. Microbiol. 3 96 483-96

The inactivating factor of glutamine synthetase IF17 is an intrinsically disordered protein, which folds upon binding to its target.

Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI, Neira JL, 2011 Nov Biochemistry 45 50 9767-78

Mutational analysis of the inactivating factors, IF7 and IF17 from Synechocystis sp. PCC 6803: critical role of arginine amino acid residues for glutamine synthetase inactivation.

Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI, 2011 Nov Mol Microbiol 4 82 964-75

Posttranscriptional regulation of glutamine synthetase in the filamentous Cyanobacterium Anabaena sp. PCC 7120: differential expression between vegetative cells and heterocysts.

Galmozzi CV, Saelices L, Florencio FJ, Muro-Pastor MI, 2010 Sep J. Bacteriol. 18 192 4701-11

Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.

Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J, 2007 Nov Mol. Genet. Genomics 5 278 527-37