Disease-associated patterns of acetylation stabilize tau fibril formation.
Li L, Nguyen B, Mullapudi V, Saelices L, Joachimiak LA, 2023 Jan bioRxivUpdate on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis.
Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL, 2022 Aug Curr Heart Fail RepInhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS, 2021 Mar bioRxivThe inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.
Cao Q, Anderson DH, Liang WY, Chou JA, Saelices L, 2020 Aug J. Biol. Chem.A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils.
Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS 2019 Feb J. Biol. Chem.Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.
Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS, 2018 07 Proc. Natl. Acad. Sci. U.S.A. 29 115 E6741-E6750Crystal structures of amyloidogenic segments of human transthyretin.
Saelices L, Sievers SA, Sawaya MR, Eisenberg DS, 2018 07 Protein Sci. 7 27 1295-1303Uncovering the Mechanism of Aggregation of Human Transthyretin.
Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS 2015 Oct J. Biol. Chem.Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.
Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J, 2007 Nov Mol. Genet. Genomics 5 278 527-37Book Chapters
Saelices L, Galmozzi CV, Florencio FJ, Muro-Pastor MI (2011) Chapter of the book "Avances en el metabolismo del nitrógeno. Aproximación molecular al estudio del ciclo del nitrógeno en la biosfera y sus repercusiones agronómicas y medioambientales". Servicio de Publicaciones de la Univ. de Córdoba.
Structures Published on PBD
Full-length transthyretin variants: 6E71, 6E75, 6E76, 4TLU, 4TNF, 4TNG, 4TKW, 4TL4, 4TL5, 4TLK, 4TLS, 4TLT, 4TM9, 4TNE
Full-length transthyretin variants with stabilizing ligands: 6E6Z, 6E70, 6E72, 6E74, 6E73, 6E77, 6E78
Peptides in their amyloid state: 6C3F, 6C3G, 6C3S, 6C3T, 6C4O, 6C88, 5VOS, 4XFN, 4XFO
Glutamine synthetase: 3NG0
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