INTERNAL MEDICINE RESEARCH
Our focus is on podocyte biology, specifically the actin dynamics and cytoskeleton.
Our research includes examining the balance of Rac and RhoA, two members of the Rho small GTPases, in both healthy and diseased kidneys. We also study the formation of sarcomere-like structures (SLSs) in glomerular pathological conditions like focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD).
Meet the PI
Hani Suleiman, M.D., Ph.D.
For over 17 years, the Dr. Suleiman has focused on actin dynamics and the cytoskeleton in podocytes, highlighting the role of Rac and RhoA balance through the GAP protein ArhGAP24 in kidney health and disease. He has adapted the super-resolution microscopic technique STORM for studying kidney histological sections and developed a method for subsequent electron microscopic examination. His work identified the molecular architecture of the glomerular basement membrane in both healthy mouse and human kidney tissue. Dr. Suleiman has also developed methods to electroporate isolated glomeruli and primary podocytes with plasmids, and created an ex vivo system to study primary podocytes on defined substrates. He has expertise in podocyte mechanobiology and the glomerular basement membrane supports collaborative research efforts and advances in kidney filtration barrier studies.
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