Publications

Featured Publications

Identification and functional characterization of the Piezo1 channel pore domain.

Nosyreva ED, Thompson D, Syeda R, 2020 Dec J Biol Chem

Dabbling with Piezo2 for mechanosensation.

Syeda R 2017 Nov Proc. Natl. Acad. Sci. U.S.A.

Piezo1 Channels Are Inherently Mechanosensitive.

Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B, Patapoutian A 2016 Nov Cell Rep 7 17 1739-1746

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A 2016 Jan Cell 3 164 499-511

The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.

Syeda R, Santos JS, Montal M 2016 Feb J. Biol. Chem. 6 291 2931-7

Mechanically Activated Ion Channels.

Ranade SS, Syeda R, Patapoutian A 2015 Sep Neuron 6 87 1162-79

Chemical activation of the mechanotransduction channel Piezo1.

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A 2015 May Elife 4

Lipid bilayer modules as determinants of K+ channel gating.

Syeda R, Santos JS, Montal M 2014 Feb J. Biol. Chem. 7 289 4233-43

Stabilization of the conductive conformation of a voltage-gated K+ (Kv) channel: the lid mechanism.

Santos JS, Syeda R, Montal M 2013 Jun J. Biol. Chem. 23 288 16619-28

Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensors.

Syeda R, Santos JS, Montal M, Bayley H 2012 Oct Proc. Natl. Acad. Sci. U.S.A. 42 109 16917-22

Piezo proteins are pore-forming subunits of mechanically activated channels.

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A 2012 Feb Nature 7388 483 176-81

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes.

Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M 2012 Dec J. Biol. Chem. 51 287 43063-70

Wrestling with native chemical ligation.

Bayley H, Cheley S, Harrington L, Syeda R 2009 Dec ACS Chem. Biol. 12 4 983-5

Screening blockers against a potassium channel with a droplet interface bilayer array.

Syeda R, Holden MA, Hwang WL, Bayley H 2008 Nov J. Am. Chem. Soc. 46 130 15543-8

Droplet interface bilayers.

Bayley H, Cronin B, Heron A, Holden MA, Hwang WL, Syeda R, Thompson J, Wallace M 2008 Dec Mol Biosyst 12 4 1191-208