Publications

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis.

Chen X, Huang J, Yu C, Liu J, Gao W, Li J, Song X, Zhou Z, Li C, Xie Y, Kroemer G, Liu J, Tang D, Kang R, 2022 Oct Nat Commun 1 13 6318

Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis.

Wu R, Liu J, Wang N, Zeng L, Yu C, Chen F, Wang H, Billiar TR, Jiang J, Tang D, Kang R, 2022 Aug Sci Transl Med 659 14 eabo2028

TMEM164 is a new determinant of autophagy-dependent ferroptosis.

Liu J, Liu Y, Wang Y, Li C, Xie Y, Klionsky DJ, Kang R, Tang D, 2022 Aug Autophagy 1-12

Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.

Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R, 2022 Apr Autophagy 1-21

Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges.

Tang D, Kroemer G, Kang R, 2021 Oct Mol Cancer 1 20 128

Targeting ferroptosis in pancreatic cancer: a double-edged sword.

Chen X, Kang R, Kroemer G, Tang D, 2021 May Trends Cancer

Broadening horizons: the role of ferroptosis in cancer.

Chen X, Kang R, Kroemer G, Tang D, 2021 May Nat Rev Clin Oncol 5 18 280-296

Ion Channels and Transporters in Autophagy.

Zhang R, Kang R, Klionsky DJ, Tang D, 2021 Mar Autophagy 1-20

MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.

Kuang F, Liu J, Xie Y, Tang D, Kang R, 2021 Jun Cell Chem Biol 6 28 765-775.e5

Ferroptosis in infection, inflammation, and immunity.

Chen X, Kang R, Kroemer G, Tang D, 2021 Jun J Exp Med 6 218

Cell death in pancreatic cancer: from pathogenesis to therapy.

Chen X, Zeh HJ, Kang R, Kroemer G, Tang D, 2021 Jul Nat Rev Gastroenterol Hepatol

Tumor heterogeneity in autophagy-dependent ferroptosis.

Li J, Liu J, Xu Y, Wu R, Chen X, Song X, Zeh H, Kang R, Klionsky DJ, Wang X, Tang D, 2021 Jan Autophagy 1-14

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.

Song X, Liu J, Kuang F, Chen X, Zeh HJ, Kang R, Kroemer G, Xie Y, Tang D, 2021 Feb Cell Rep 8 34 108767

Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.

Liu Y, Wang Y, Liu J, Kang R, Tang D, 2021 Feb Cancer Gene Ther 1-2 28 55-63

Ferroptosis: molecular mechanisms and health implications.

Tang D, Chen X, Kang R, Kroemer G, 2021 Feb Cell Res 2 31 107-125

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.

Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D, 2021 04 Autophagy 4 17 948-960

TMEM173 Drives Lethal Coagulation in Sepsis.

Zhang H, Zeng L, Xie M, Liu J, Zhou B, Wu R, Cao L, Kroemer G, Wang H, Billiar TR, Zeh HJ, Kang R, Jiang J, Yu Y, Tang D, 2020 Feb Cell Host Microbe

Ferroptosis: machinery and regulation.

Chen X, Li J, Kang R, Klionsky DJ, Tang D, 2020 Aug Autophagy 1-28

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.

Dai E, Han L, Liu J, Xie Y, Zeh HJ, Kang R, Bai L, Tang D, 2020 12 Nat Commun 1 11 6339

Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling.

Zhou B, Liu J, Zeng L, Zhu S, Wang H, Billiar TR, Kroemer G, Klionsky DJ, Zeh HJ, Jiang J, Tang D, Kang R, 2020 12 Nat Microbiol 12 5 1576-1587

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein.

Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky DJ, Zeh HJ, Kang R, Wang J, Tang D, 2020 11 Autophagy 11 16 2069-2083

cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.

Chen R, Zeng L, Zhu S, Liu J, Zeh HJ, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D, Kang R, 2019 May Sci Adv 5 5 eaav5562

Clockophagy is a novel selective autophagy process favoring ferroptosis.

Yang M, Chen P, Liu J, Zhu S, Kroemer G, Klionsky DJ, Lotze MT, Zeh HJ, Kang R, Tang D, 2019 07 Sci Adv 7 5 eaaw2238

The molecular machinery of regulated cell death.

Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G, 2019 05 Cell Res 5 29 347-364

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B 2018 Oct Immunity 4 49 740-753.e7

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis.

Chen R, Zhu S, Fan XG, Wang H, Lotze MT, Zeh HJ, Billiar TR, Kang R, Tang D 2018 May Hepatology 5 67 1823-1841

Activity.

Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D 2018 Jul Curr. Biol.

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.

Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, Cao L, Xie M, Ran Q, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D 2018 Jul Cell Host Microbe 1 24 97-108.e4

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.

Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, Xie M, Tang D 2018 Jul Cell Rep 2 24 366-378

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism.

Li C, Zhang Y, Cheng X, Yuan H, Zhu S, Liu J, Wen Q, Xie Y, Liu J, Kroemer G, Klionsky DJ, Lotze MT, Zeh HJ, Kang R, Tang D 2018 08 Dev. Cell 4 46 441-455.e8

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D 2018 04 Gastroenterology 5 154 1480-1493

ALK is a therapeutic target for lethal sepsis.

Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, Billiar TR, Jiang J, Tang D 2017 Oct Sci Transl Med 412 9

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD 2017 Oct Cell 2 171 273-285

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer.

Kang R, Xie Y, Zhang Q, Hou W, Jiang Q, Zhu S, Liu J, Zeng D, Wang H, Bartlett DL, Billiar TR, Zeh HJ, Lotze MT, Tang D 2017 Jul Cell Res. 7 27 916-932

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.

Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ, Kang R, Kroemer G, Tang D 2017 Aug Cell Rep 7 20 1692-1704

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.

Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, Kroemer G, Lotze M, Zeh HJ, Kang R, Tang D 2017 11 Gastroenterology 5 153 1429-1443.e5

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.

Xie M, Yu Y, Kang R, Zhu S, Yang L, Zeng L, Sun X, Yang M, Billiar TR, Wang H, Cao L, Jiang J, Tang D 2016 Oct Nat Commun 7 13280

Autophagy promotes ferroptosis by degradation of ferritin.

Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ, Kang R, Tang D 2016 May Autophagy 1-4

Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis.

Sun X, Niu X, Chen R, He W, ChenKang R, Tang D 2016 Mar Hepatology

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis.

Kang R, Zeng L, Xie Y, Yan Z, Zhou B, Cao L, Klionsky DJ, Tracey KJ, Li J, Wang H, Billiar TR, Jiang J, Tang D 2016 Dec Autophagy 12 12 2374-2385

Activation of the p62-Keap1-NRF2 Pathway Protects against Ferroptosis in Hepatocellular Carcinoma Cells.

Sun X, Ou Z, Chen R, Niu X, ChenKang R, Tang D 2015 Sep Hepatology

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.

Yang M, Liu L, Xie M, Sun X, Yu Y, Kang R, Yang L, Zhu S, Cao L, Tang D 2015 Jan Autophagy 0

HMGB1 in health and disease.

Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, Huang J, Yu Y, Fan XG, Yan Z, Sun X, Wang H, Wang Q, Tsung A, Billiar TR, Zeh HJ, Lotze MT, Tang D 2014 Jul Mol. Aspects Med.

Intracellular hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.

Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, Bansal P, Billiar TR, Tsung A, Wang Q, Bartlett DL, Whitcomb DC, Chang EB, Zhu X, Wang H, Lu B, Tracey KJ, Cao L, Fan XG, Lotze MT, Zeh HJ, Tang D 2014 Apr Gastroenterology 4 146 1097-1107.e8

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.

Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze MT, Billiar TR, Wang H, Cao L, Tang D 2014 Nat Commun 5 4436

Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNa in chronic myeloid leukemia cells.

Zhu S, Cao L, Yu Y, Yang L, Yang M, Liu K, Huang J, Kang R, Livesey KM, Tang D 2013 Mar Autophagy 3 9 317-27

The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.

Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM, Krasinskas A, Lotze MT, Zeh HJ 2012 May Proc. Natl. Acad. Sci. U.S.A. 18 109 7031-6

HMGB1 promotes drug resistance in osteosarcoma.

Huang J, Ni J, Liu K, Yu Y, Xie M, Kang R, Vernon P, Cao L, Tang D 2012 Jan Cancer Res. 1 72 230-8

p53/HMGB1 complexes regulate autophagy and apoptosis.

Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ, Li L, Lotze MT, Tang D 2012 Apr Cancer Res. 8 72 1996-2005

High-mobility group box 1 is essential for mitochondrial quality control.

Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT 2011 Jun Cell Metab. 6 13 701-11

Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARa oncoprotein.

Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D 2011 Apr Autophagy 4 7 401-11

Endogenous HMGB1 regulates autophagy.

Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, Hoppe G, Bianchi ME, Tracey KJ, Zeh HJ, Lotze MT 2010 Sep J. Cell Biol. 5 190 881-92

To view more publications from the Tang Lab, please visit the National Library of Medicine.