Our laboratory’s focus is to understand the intrinsic roles of lysosomes and their regulatory functions in cellular and organismal homeostasis, with the ultimate goal of identifying novel therapeutic targets for a wide range of disease conditions.

Our laboratory aims to understand the role of metabolic adaptive mechanisms in cancer progression.

Our goal is to better understand the mechanisms that maintain adult tissues and how cancer cells hijack these mechanisms to enable the formation of tumors.

We study the role of chromatin regulation in cell fate decisions.

We are interested in the relationship between metabolism and cell type. We focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny including cells of the myeloid and T cell lineages.