Our laboratory’s focus is to understand the intrinsic roles of lysosomes and their regulatory functions in cellular and organismal homeostasis, with the ultimate goal of identifying novel therapeutic targets for a wide range of disease conditions.

Our laboratory aims to understand the role of metabolic adaptive mechanisms in cancer progression.

The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer. 

The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.

Our goal is to better understand the mechanisms that maintain adult tissues and how cancer cells hijack these mechanisms to enable the formation of tumors.

Our research focuses on how mitochondria are embedded in normal cellular function.

Our goal is to identify the metabolic mechanisms that push cells to become cancerous and find new ways to inhibit them.

Using novel multi-omics approaches and model systems to treat pancreatic cancer

We study the role of chromatin regulation in cell fate decisions.

We are interested in the relationship between metabolism and cell type. We focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny including cells of the myeloid and T cell lineages.