Publications

Comprehensive phenotypic analysis of diverse FOXN1 variants

Moses, A., Bhalla, P., Thompson, A., Lai, L., Coskun, F. S., Seroogy, C. M., de la Morena, M. T., Wysocki, C. A., van Oers, N. S. C. 2023 5 152 1273-1291

Mesenchymal cell replacement corrects thymus hypoplasia in murine models of 22q11.2 deletion syndrome.

Bhalla P, Du Q, Kumar A, Xing C, Moses A, Dozmorov I, Wysocki CA, Cleaver OB, Pirolli TJ, Markert ML, de la Morena MT, Baldini A, van Oers NS, 2022 Sep J Clin Invest

Thymus Functionality Needs More Than a Few TECs.

Bhalla P, Su DM, van Oers NSC, 2022 Front Immunol 13 864777

Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses.

Pichilingue-Reto P, Raj P, Li QZ, Dozmorov I, Karp DR, Wakeland EK, Nelson M, Gruchalla RS, de la Morena MT, van Oers NSC, 2021 Mar J Clin Immunol

SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency.

van Oers NSC, Hanners NW, Sue P, Aquino V, Li QZ, Schoggins JW, Wysocki CA, 2021 Jan Clin Immunol 108662

Impact of Bead-Beating Intensity on the Genus- and Species-Level Characterization of the Gut Microbiome Using Amplicon and Complete 16S rRNA Gene Sequencing.

Zhang B, Brock M, Arana C, Dende C, van Oers NS, Hooper LV, Raj P, 2021 Front Cell Infect Microbiol 11 678522

Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

Raj P, Song R, Zhu H, Riediger L, Jun DJ, Liang C, Arana C, Zhang B, Gao Y, Wakeland BE, Dozmorov I, Zhou J, Kelly JA, Lauwerys BR, Guthridge JM, Olsen NJ, Nath SK, Pasare C, van Oers N, Gilkeson G, Tsao BP, Gaffney PM, Gregersen PK, James JA, Zuo X, Karp DR, Li QZ, Wakeland EK, 2020 Nov Genome Biol 1 21 281

The Genetics and Epigenetics of 22q11.2 Deletion Syndrome

Du,Qiumei de la Morena,M. Teresa van Oers,Nicolai S. C. 2020

Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models

Bhalla,Pratibha Wysocki,Christian A. van Oers,Nicolai S. C. 2020

sncRNA-1 Is a Small Noncoding RNA Produced by Mycobacterium tuberculosis in Infected Cells That Positively Regulates Genes Coupled to Oleic Acid Biosynthesis

Coskun, Fatma S. Srivastava, Shashikant Raj, Prithvi Dozmorov, Igor Belkaya, Serkan Mehra, Smriti Golden, Nadia A. Bucsan, Allison N. Chapagain, Moti L. Wakeland, Edward K. Kaushal, Deepak Gumbo, Tawanda van Oers, Nicolai S. C. 2020 1631 11

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.

Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC, 2019 Apr Dev. Cell

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans

Qiumei Du,1 Larry K. Huynh,1 Fatma Coskun,1 Erika Molina,1 Matthew A. King,1 Prithvi Raj,1 Shaheen Khan,1 Igor Dozmorov,1 Christine M. Seroogy,2 Christian A. Wysocki,3,4 Grace T. Padron,5 Tyler R. Yates,6 M. Louise Markert,6,7 M. Teresa de la Morena,8 and Nicolai S.C. van Oers1,3,9 2019

MicroRNA-205 maintains T cell development following stress by regulating Forkhead box N1 and selected chemokines.

Hoover AR, Dozmorov I, MacLeod J, Du Q, de la Morena MT, Forbess J, Guleserian K, Cleaver OB, van Oers NS 2016 Sep J. Biol. Chem.

The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.

DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS 2011 Jun J. Immunol. 12 186 6839-47

Dynamic modulation of thymic microRNAs in response to stress.

Belkaya S, Silge RL, Hoover AR, Medeiros JJ, Eitson JL, Becker AM, de la Morena MT, Bassel-Duby RS, van Oers NS 2011 PLoS ONE 11 6 e27580

Spatiotemporal patterning during T cell activation is highly diverse.

Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C 2009 Sci Signal 65 2 ra15

Selective Expression of the 21-Kilodalton Tyrosine-Phosphorylated Form of TCR {zeta} Promotes the Emergence of T Cells with Autoreactive Potential

Pitcher, L. A.,Mathis, M. A., Subramanian, S., Young, J. A., Wakeland, E. K., Love, P. E.,van Oers, N. S. May 2005 174 6071-9

The Membrane-proximal Portion of CD3 {epsilon} Associates with the Serine/Threonine Kinase GRK2

DeFord-Watts, L.A., Young, J. A.,Pitcher, L. A.,van Oers, N. S. June 2007 282 16126-16134

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Purtic, B., Pitcher, L. A., van Oers, N. S., Wulfing, C. February 2005 102 2904-9

The CD3 ge/de signaling module provides normal T cell functions in the absence of the TCR z-ITAMs

Pitcher, L.A.,Mathis, M.A.,Young, J. A., DeFord, L.M., Purtic, B., Wulfing, C., van Oers, N.S.C. December 2005 In Press

The Constitutive Tyrosine Phosphorylation of CD3{zeta} Results from TCR-MHC Interactions That Are Independent of Thymic Selection

Becker, A. M.,Deford-Watts, L. M.,Wuelfing, C.,van Oers, N. S. April 2007 178 4120-8

Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations.

Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NS, Wang RC, Garcia CK 2017 Mar J. Clin. Invest. 3 127 982-986

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells.

Gonzales-van Horn SR, Estrada LD, van Oers NS, Farrar JD 2016 Mar Eur. J. Immunol.

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8.

Khan S, Kuruvilla M, Hagin D, Wakeland B, Liang C, Vishwanathan K, Gatti RA, Torgersen TR, Abraham RS, Wakeland EK, van Oers NS, de la Morena MT 2016 Feb J. Allergy Clin. Immunol.

The Haemophilus ducreyi LspA1 Protein Inhibits Phagocytosis By Using a New Mechanism Involving Activation of C-Terminal Src Kinase.

Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ 2014 MBio 3 5

Basal and antigen-induced exposure of the proline-rich sequence in CD3e.

de la Cruz J, Kruger T, Parks CA, Silge RL, van Oers NS, Luescher IF, Schrum AG, Gil D 2011 Feb J. Immunol. 4 186 2282-90

A novel missense mutation in the nuclear factor-?B essential modulator (NEMO) gene resulting in impaired activation of the NF-?B pathway and a unique clinical phenotype presenting as MRSA subdural empyema.

Devora GA, Sun L, Chen Z, van Oers NS, Hanson EP, Orange JS, de la Morena MT 2010 Nov J. Clin. Immunol. 6 30 881-5

Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.

Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS 2010 Jun J. Immunol. 12 184 6822-32

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.

Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA 2008 Jun Nat. Immunol. 6 9 658-66