Publications

Featured Publications

FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.

Zhu Z, Lou G, Teng XL, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C, Wu T, 2023 Nov Nat Immunol

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.

Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, 2021 Mar Nat Immunol 3 22 370-380

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.

Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T, 2019 07 Nat. Immunol. 7 20 890-901

The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL 2016 Dec Sci Immunol 6 1

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.

Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL, 2015 Sep Cell Rep 12 12 2099-110

Facts and hopes for immunotherapy in renal cell carcinoma.

Yao C, Zhang T, Wu T, Brugarolas J, 2022 Jul Clin Cancer Res

IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection.

Huang Z, Zak J, Pratumchai I, Shaabani N, Vartabedian VF, Nguyen N, Wu T, Xiao C, Teijaro JR, 2019 08 J Exp Med 8 216 1791-1808

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate.

Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, Lacey NE, Gautam S, Le Gall JB, Yang X, Hocker JD, Escobar TM, He S, Dell'Orso S, Hawk NV, Kapoor V, Telford WG, Di Croce L, Muljo SA, Zhang Y, Sartorelli V, Gattinoni L, 2019 05 Nat Commun 1 10 2157

Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation.

Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB, 2016 Oct Sci Immunol 4 1

mTOR promotes anti-viral humoral immunity by differentially regulating CD4 helper T cell and B cell responses.

Ye L, Lee J, Xu L, Mohammed AU, Li W, Hale JS, Tan WG, Wu T, Davis CW, Ahmed R, Araki K 2016 Dec J. Virol.

Cutting Edge: miR-17-92 Is Required for Both CD4 Th1 and T Follicular Helper Cell Responses during Viral Infection.

Wu T, Wieland A, Lee J, Hale JS, Han JH, Xu X, Ahmed R, 2015 Sep J Immunol 6 195 2515-9

Distinct Memory CD4(+) T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection.

Hale JS, Youngblood B, Latner DR, Mohammed AU, Ye L, Akondy RS, Wu T, Iyer SS, Ahmed R 2013 Apr Immunity 4 38 805-17

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.

Wu T, Wieland A, Araki K, Davis CW, Ye L, Hale JS, Ahmed R 2012 Jun Proc. Natl. Acad. Sci. U.S.A. 25 109 9965-70

TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.

Sun P, Quan Z, Zhang B, Wu T, Xi R, 2010 Aug Development 15 137 2461-9

Binding of the environmental pollutant naphthol to bovine serum albumin.

Wu T, Wu Q, Guan S, Su H, Cai Z, 2007 Jun Biomacromolecules 6 8 1899-906