Publications

Featured Publications

Brain-wide circuit-specific targeting of astrocytes.

Thompson A, Arano R, Saleem U, Preciado R, Munoz L, Nelson I, Ramos K, Kim Y, Li Y, Xu W, 2023 Nov Cell Rep Methods 100653

Directed stepwise tracing of polysynaptic neuronal circuits with replication-deficient pseudorabies virus.

Du W, Li E, Guo J, Arano R, Kim Y, Chen YT, Thompson A, Oh SJ, Samuel A, Li Y, Oyibo HK, Xu W, 2023 Jun Cell Rep Methods 6 3 100506

Anterograde transneuronal tracing and genetic control with engineered yellow fever vaccine YFV-17D.

Li E, Guo J, Oh SJ, Luo Y, Oliveros HC, Du W, Arano R, Kim Y, Chen YT, Eitson J, Lin DT, Li Y, Roberts T, Schoggins JW, Xu W, 2021 Nov Nat Methods

A neural circuit for memory specificity and generalization.

Xu W, Südhof TC 2013 Mar Science 6125 339 1290-5

Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission.

Xu W, Morishita W, Buckmaster PS, Pang ZP, Malenka RC, Südhof TC 2012 Mar Neuron 5 73 990-1001

Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior.

Chen YT, Arano R, Guo J, Saleem U, Li Y, Xu W, 2023 Front Synaptic Neurosci 15 1042858

Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.

Zhou M, Melin MD, Xu W, Südhof TC, 2020 10 J Clin Invest 10 130 5142-5156

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.

Zhou M, Liu Z, Melin MD, Ng YH, Xu W, Südhof TC 2018 Nov Nat. Neurosci. 11 21 1515-1519

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP.

Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC, Südhof TC 2017 Mar Nature

Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.

Li YC, Chanaday NL, Xu W, Kavalali ET 2016 Dec Neuron

Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments.

Liang J, Xu W, Hsu YT, Yee AX, Chen L, Südhof TC 2015 Mar Mol. Psychiatry

Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release.

Bacaj T, Wu D, Yang X, Morishita W, Zhou P, Xu W, Malenka RC, Südhof TC 2013 Nov Neuron 4 80 947-59

Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.

Xu W, Tse YC, Dobie FA, Baudry M, Craig AM, Wong TP, Wang YT 2013 Mar J. Neurosci. 13 33 5867-77

Rapid single-step induction of functional neurons from human pluripotent stem cells.

Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, Südhof TC 2013 Jun Neuron 5 78 785-98

Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development.

Anderson GR, Galfin T, Xu W, Aoto J, Malenka RC, Südhof TC 2012 Oct Proc. Natl. Acad. Sci. U.S.A. 44 109 18120-5

CSPa knockout causes neurodegeneration by impairing SNAP-25 function.

Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC 2012 Feb EMBO J. 4 31 829-41

RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.

Deng L, Kaeser PS, Xu W, Südhof TC 2011 Jan Neuron 2 69 317-31

Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.

Pang ZP, Bacaj T, Yang X, Zhou P, Xu W, Südhof TC 2011 Apr Neuron 2 70 244-51

Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.

Pang ZP, Xu W, Cao P, Südhof TC 2010 Oct J. Biol. Chem. 44 285 33930-9

Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.

Pang ZP, Cao P, Xu W, Südhof TC 2010 Mar J. Neurosci. 11 30 4132-42

SIRT1 is essential for normal cognitive function and synaptic plasticity.

Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD 2010 Jul J. Neurosci. 29 30 9695-707

Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory a helix.

Yang X, Kaeser-Woo YJ, Pang ZP, Xu W, Südhof TC 2010 Dec Neuron 5 68 907-20

Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1alpha truncation.

Zhou M, Xu W, Liao G, Bi X, Baudry M 2009 Jul Exp. Neurol. 1 218 75-82

Neuroprotection by cell permeable TAT-mGluR1 peptide in ischemia: synergy between carrier and cargo sequences.

Wei Xu null, Miou Zhou null, Baudry M 2008 Oct Neuroscientist 5 14 409-14

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.

Li Y, Xu W, McBurney MW, Longo VD 2008 Jul Cell Metab. 1 8 38-48

Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.

Xu W, Wong TP, Chery N, Gaertner T, Wang YT, Baudry M 2007 Feb Neuron 3 53 399-412

Antinociceptive effect of calcitonin gene-related peptide in the central nucleus of amygdala: activating opioid receptors through amygdala-periaqueductal gray pathway.

Xu W, Lundeberg T, Wang YT, Li Y, Yu LC 2003 Neuroscience 4 118 1015-22