Publications

 

Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M. W. & Wagner, G. (2000) Structure of the Mad2 Spindle Assembly Checkpoint Protein and Its Interaction with Cdc20. Nat. Struct. Biol., 7, 224-229.

Luo, X., Tang, Z., Rizo, J. & Yu, H. (2002) The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20. Mol. Cell, 9, 59-71.

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., & Yu, H. (2004) The Mad2 Spindle Checkpoint Protein Has Two Distinct Natively Folded States. Nat. Struct. Mol. Biol., 4, 338-45.

Yang, M., Li, B., Tomchick, DR., Machius, M., Rizo, J., Yu, H. & Luo, X. (2007) p31comet Blocks Mad2 Activation through Structural Mimicry. Cell, 131, 744-755. PMCID: PMC2144745

Yang, M., Li, B., Liu, C., Tomchick, D.R., Machius, M., Rizo, J., Yu, H. and Luo, X. (2008) Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 dimer. PLoS Biol., 6, 643-655. PMCID: PMC2270309

Luo, X. & Yu, H. (2008) Protein Metamorphosis: The Two-State Behavior of Mad2 (invited review). Structure, 16, 1616-25.

Tian, W., Yu, J., Tomchick, D., Pan, D. and Luo, X. (2010) Structural and Functional Analysis of the YAP-binding Domain of Human TEAD2. Proc. Natl. Acad. Sci. U.S.A., 107, 7293-8. PMCID: PMC2867681

Luo, X. (2010) Snapshots of a Hybrid Transcription Factor in the Hippo Pathway (invited review). Protein Cell, 1, 811-9.

Kim, S., Sun, H., Ball, H., Wassmann, K., Luo, X.*, & Yu, H.* (2010) Phosphorylation of the Spindle Checkpoint Protein Mad2 Regulates Its Conformational Transition. Proc. Natl. Acad. Sci. U.S.A., 107, 19772-7. (*Corresponding authors) PMCID: PMC2993392

Kim, S., Sun, H., Tomchick, D.R., Yu, H., and Luo, X. (2012) Structure of Human Mad1 C-terminal Domain Reveals Its Kinetochore-Targeting Function. Proc. Natl. Acad. Sci. U.S.A., 109, 6549-54. (covered in Research Highlights article, “Mad1 attachment” by M. Montoya, Nat. Struct. Mol. Biol. 19 (2012): 470). PMCID: PMC3340083

Tian, W., Li, B., Warrington, R., Tomchick, D.R., Yu, H. and Luo, X. (2012) Structural Analysis of Human Cdc20 Supports Multisite Degron Recognition by APC/C. Proc. Natl. Acad. Sci. U.S.A., 109, 18419-24. PMCID: PMC3494910

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C.A., Tomchick, D.R., Pan, D. and Luo, X. (2013) Structural Basis for Autoactivation of Human Mst2 Kinase and Its Dual Regulation by RASSF5. Structure, 21, 1757-68. PMCID: PMC3797246

Sackton, K., Dimova, N., Zeng, X., Tian, W., Zhang, M., Sackton, T., Meaders, J., Pfaff, K., Sigoillot, F., Yu, H., Luo, X., & King, R.W. (2014) Synergistic Blockade of Mitotic Exit by Two Chemical Inhibitors of the APC/C. Nature, 514, 646-9. PMCID: PMC4214887

Diaz-Martinez, L.A., Tian, W., Li, B., Warrington, R., Jia, L., Brautigam, C.A., Luo, X., & Yu, H. (2015) The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex during Mitosis. J Biol. Chem., 290, 2431-43. PMCID: PMC4303692

Ni, L., Zheng, Y., Hara, M., Pan, D. and Luo, X. (2015) Structural Basis for Mob1-Dependent Activation of the Core Mst-Lats Kinase Cascade in Hippo Signaling. Genes Dev, 29, 1416-31. PMCID: PMC4511216