Publications for Xuewu Zhang, Ph.D.

Structural basis of insulin fibrillation.

Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC, 2023 Sep Sci Adv 37 9 eadi1057

Activation of human STING by a molecular glue-like compound.

Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y, 2023 Oct Nat Chem Biol

Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ.

Wu X, Zhao Y, Zhang H, Yang W, Yang J, Sun L, Jiang M, Wang Q, Wang Q, Ye X, Zhang X, Wu Y, 2023 Jan Nat Commun 1 14 479

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold.

Liu S, Chen H, Yin Y, Lu D, Gao G, Li J, Bai XC, Zhang X, 2023 Apr Sci Adv 14 9 eadf5583

Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction.

Dong X, Liang Q, Pan YZ, Wang X, Kuo YC, Chiang WC, Zhang X, Williams NS, Rizo J, Levine B, De Brabander JK, 2022 Sep ACS Med Chem Lett 9 13 1510-1516

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.

Stepien KP, Xu J, Zhang X, Bai XC, Rizo J, 2022 Jun Sci Adv 25 8 eabo5272

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.

Cai K, Zhang X, Bai XC, 2022 Jun Chem Rev

Synergistic activation of the insulin receptor via two distinct sites.

Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC, 2022 Apr Nat Struct Mol Biol 4 29 357-368

Activation of STING by targeting a pocket in the transmembrane domain.

Lu D, Shang G, Li J, Lu Y, Bai XC, Zhang X, 2022 04 Nature 7906 604 557-562

Python-based Helix Indexer: A graphical user interface program for finding symmetry of helical assembly through Fourier-Bessel indexing of electron microscopic data.

Zhang X, 2022 01 Protein Sci 1 31 107-117

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation.

Liu Y, Ke P, Kuo YC, Wang Y, Zhang X, Song C, Shan Y, 2021 Jun Elife 10

Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X, 2021 Feb Nat Struct Mol Biol

Structural basis of the activation of c-MET receptor.

Uchikawa E, Chen Z, Xiao GY, Zhang X, Bai XC, 2021 07 Nat Commun 1 12 4074

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.

Lu D, Shang G, He X, Bai XC, Zhang X, 2021 05 Nat Commun 1 12 3172

Structural and Functional Analyses of the FAM46C/Plk4 Complex.

Chen H, Lu D, Shang G, Gao G, Zhang X, 2020 May Structure

Sorting nexin 5 mediates virus-induced autophagy and immunity.

Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B, 2020 Dec Nature

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation.

Kuo YC, Chen H, Shang G, Uchikawa E, Tian H, Bai XC, Zhang X, 2020 04 Nat Commun 1 11 1953

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.

Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC, 2019 Sep Elife 8

Effector Specificity Mechanisms of Rab35 GTPase.

Kuo YC, Zhang X, 2019 05 Structure 5 27 725-727

Structural basis of STING binding with and phosphorylation by TBK1.

Zhang C, Shang G, Gui X, Zhang X, Bai XC, Chen ZJ, 2019 03 Nature 7748 567 394-398

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.

Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X, 2019 03 Nature 7748 567 389-393

Structural analyses of FERM domain-mediated membrane localization of FARP1.

Kuo YC, He X, Coleman AJ, Chen YJ, Dasari P, Liou J, Biederer T, Zhang X 2018 Jul Sci Rep 1 8 10477

Regulation of tankyrase activity by a catalytic domain dimer interface.

Fan C, Yarravarapu N, Chen H, Kulak O, Dasari P, Herbert J, Yamaguchi K, Lum L, Zhang X 2018 09 Biochem. Biophys. Res. Commun. 3 503 1780-1785

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.

Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L 2017 Oct Nat. Cell Biol. 10 19 1226-1236

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.

Shang G, Brautigam CA, Chen R, Lu D, Torres-Vázquez J, Zhang X 2017 May Elife 6

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling.

Qi N, Shi Y, Zhang R, Zhu W, Yuan B, Li X, Wang C, Zhang X, Hou F 2017 Jun Nat Commun 8 15676

In Vitro Assay for the Rap GTPase-Activating Protein Activity of the Purified Cytoplasmic Domain of Plexin.

Pascoe HG, Wang Y, Zhang X 2017 Methods Mol. Biol. 1493 107-118

Regulation of Plexin: A Ring of Structural Twists and Turns.

Kuo YC, Zhang X, 2016 Aug Neuron 3 91 497-9

Plexins function in epithelial repair in both Drosophila and zebrafish.

Yoo SK, Pascoe HG, Pereira T, Kondo S, Jacinto A, Zhang X, Hariharan IK 2016 Nat Commun 7 12282

Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface.

Marita M, Wang Y, Kaliszewski MJ, Skinner KC, Comar WD, Shi X, Dasari P, Zhang X, Smith AW 2015 Nov Biophys. J. 9 109 1937-45

Structural mechanisms of plexin signaling.

Pascoe HG, Wang Y, Zhang X 2015 Mar Prog. Biophys. Mol. Biol.

Disruption of Wnt/?-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L 2015 Jul Mol. Cell. Biol. 14 35 2425-35

Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.

Pascoe HG, Gutowski S, Chen H, Brautigam CA, Chen Z, Sternweis PC, Zhang X 2015 Dec Proc. Natl. Acad. Sci. U.S.A. 48 112 14852-7

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.

Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ 2014 Feb Cell Rep 3 6 421-30

Structural basis for the prion-like MAVS filaments in antiviral innate immunity.

Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX 2014 Elife 3 e01489

Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.

He X, Kuo YC, Rosche TJ, Zhang X 2013 Mar Structure 3 21 355-64

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP 2013 Jun J. Exp. Med.

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ 2013 Jun Mol. Cell

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Wang Y, Pascoe HG, Brautigam CA, He H, Zhang X. 2013 eLife 2 e01279

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE 2012 May Cell 4 149 860-70

Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.

Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X 2012 Sci Signal 207 5 ra6

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.

Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J 2011 Mar Nat Rev Urol 3 8 165-71

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J 2011 Apr Mol. Cell 1 42 9-22

Structural analysis and functional implications of the negative mTORC1 regulator REDD1.

Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, Zhang X 2010 Mar Biochemistry 11 49 2491-501

Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.

He H, Yang T, Terman JR, Zhang X 2009 Sep Proc. Natl. Acad. Sci. U.S.A. 37 106 15610-5

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J 2007 Nov Nature 7170 450 741-4

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.

Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J 2006 Jun Cell 6 125 1137-49

Structural and functional analysis of the costimulatory receptor programmed death-1.

Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC, 2004 Mar Immunity 3 20 337-47

Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.

Zhang X, Schwartz JC, Almo SC, Nathenson SG, 2003 Mar Proc. Natl. Acad. Sci. U.S.A. 5 100 2586-91

Structural mechanisms of costimulation.

Schwartz JC, Zhang X, Nathenson SG, Almo SC, 2002 May Nat. Immunol. 5 3 427-34

Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.

Zhang X, Schwartz JC, Almo SC, Nathenson SG, 2002 Jun Protein Expr. Purif. 1 25 105-13

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.

Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC 2001 Mar Nature 6828 410 604-8