Featured Publications
KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation.
Xun Y, Jiang Y, Khalid A, Tian Z, Rios J, Zhang Z, 2024 Nov Cell Death DifferDynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3KBTBD2.
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L, 2024 Feb Nat Struct Mol Biol 2 31 336-350Central regulation of feeding and body weight by ciliary GPR75.
Jiang Y, Xun Y, Zhang Z, 2024 Aug J Clin InvestOVOL2: an epithelial lineage determiner with emerging roles in energy homeostasis.
Jiang Y, Zhang Z, 2023 Jun Trends Cell Biol
Zhang Z,
2023 Aug
STAR Protoc
3
4
102518
Zhang Z, Jiang Y, Su L, Ludwig S, Zhang X, Tang M, Li X, Anderton P, Zhan X, Choi M, Russell J, Bu CH, Lyon S, Xu D, Hildebrand S, Scott L, Quan J, Simpson R, Sun Q, Qin B, Collie T, Tadesse M, Moresco EMY, Beutler B,
2022 Oct
Cell Metab
Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.
Zhang Z, Xun Y, Rong S, Yan L, SoRelle JA, Li X, Tang M, Keller K, Ludwig S, Moresco EMY, Beutler B, 2022 Jul Nat Commun 1 13 4136
Zhang Z, Gallagher T, Scherer PE, Beutler B,
2020 May
Proc. Natl. Acad. Sci. U.S.A.
21
117
11829-11835
Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2.
Jiang Y, Peng J, Song J, He J, Jiang M, Wang J, Ma L, Wang Y, Lin M, Wu H, Zhang Z, Gao D, Zhao Y, 2021 Nov Nat Metab 11 3 1569-1584
Xu D, Lyon S, Bu CH, Hildebrand S, Choi JH, Zhong X, Liu A, Turer EE, Zhang Z, Russell J, Ludwig S, Mahrt E, Nair-Gill E, Shi H, Wang Y, Zhang D, Yue T, Wang KW, SoRelle JA, Su L, Misawa T, McAlpine W, Sun L, Wang J, Zhan X, Choi M, Farokhnia R, Sakla A, Schneider S, Coco H, Coolbaugh G, Hayse B, Mazal S, Medler D, Nguyen B, Rodriguez E, Wadley A, Tang M, Li X, Anderton P, Keller K, Press A, Scott L, Quan J, Cooper S, Collie T, Qin B, Cardin J, Simpson R, Tadesse M, Sun Q, Wise CA, Rios JJ, Moresco EMY, Beutler B,
2021 Jul
Proc Natl Acad Sci U S A
28
118
Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.
Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B, 2020 Apr J. Exp. Med. 4 217
Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B,
2019 May
Proc. Natl. Acad. Sci. U.S.A.
LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B, 2019 05 Science 6440 364Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).
Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y 2018 Feb J Mol Cell Biolmutation causes hyperphagic obesity, diabetes and hepatic steatosis.
Turer EE, San Miguel M, Wang KW, McAlpine W, Ou F, Li X, Tang M, Zang Z, Wang J, Hayse B, Evers B, Zhan X, Russell J, Beutler B 2018 Dec Dis Model Mech 12 11
McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E
2018 12
Proc. Natl. Acad. Sci. U.S.A.
49
115
E11523-E11531
Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y,
2018 10
J Mol Cell Biol
5
10
475-478
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B 2017 Jun Proc. Natl. Acad. Sci. U.S.A. 26 114 E5197-E5206Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.
Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJ, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova JL, Puel A 2017 Feb Cell 5 168 789-800.e10Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B 2016 Oct Proc. Natl. Acad. Sci. U.S.A. 42 113 E6418-E6426
Lv X, Pan C, Zhang Z, Xia Y, Chen H, Zhang S, Guo T, Han H, Song H, Zhang L, Zhao Y
2016 Mar
Development
Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z
2015 Jun
J. Biol. Chem.
Real-time resolution of point mutations that cause phenovariance in mice.
Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B 2015 Jan Proc. Natl. Acad. Sci. U.S.A.Kto-Skd complex can regulate ptc expression by interacting with Ci in Hedgehog signaling pathway.
Mao F, Yang X, Fu L, Lv X, Zhang Z, Wu W, Yang S, Zhou Z, Zhang L, Zhao Y 2014 Jun J. Biol. Chem.Hedgehog in the Drosophila testis niche: what does it do there?
Zhang Z, Pan C, Zhao Y, 2013 Sep Protein Cell 9 4 650-5Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling.
Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, Wu W, Zhou Z, Zhang L, Zhao Y, 2013 Sep J. Cell. Sci. Pt 18 126 4230-8Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.
Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, Liu F, Zhang L, Zhao Y, 2013 Nov J. Cell Biol. 4 203 575-83
Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D
2013 Nov
PLoS Biol.
11
11
e1001721
Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y
2013 Mar
J. Biol. Chem.
Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.
Zhang Z, Lv X, Yin WC, Zhang X, Feng J, Wu W, Hui CC, Zhang L, Zhao Y 2013 Jun Dev. Cell 6 25 636-44Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism.
Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L, Zhao Y, Zhou Z 2013 Feb Structure
Zhang Z, Lv X, Jiang J, Zhang L, Zhao Y
2013 Feb
Cell Res.