Publications

Featured Publications

Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3KBTBD2.

Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L, 2024 Feb Nat Struct Mol Biol 2 31 336-350

Central regulation of feeding and body weight by ciliary GPR75.

Jiang Y, Xun Y, Zhang Z, 2024 Aug J Clin Invest

OVOL2: an epithelial lineage determiner with emerging roles in energy homeostasis.

Jiang Y, Zhang Z, 2023 Jun Trends Cell Biol

Generation of epitope tag knock-in mice with CRISPR-Cas9 to study the function of endogenous proteins.

Zhang Z, 2023 Aug STAR Protoc 3 4 102518

Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis.

Zhang Z, Jiang Y, Su L, Ludwig S, Zhang X, Tang M, Li X, Anderton P, Zhan X, Choi M, Russell J, Bu CH, Lyon S, Xu D, Hildebrand S, Scott L, Quan J, Simpson R, Sun Q, Qin B, Collie T, Tadesse M, Moresco EMY, Beutler B, 2022 Oct Cell Metab

Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.

Zhang Z, Xun Y, Rong S, Yan L, SoRelle JA, Li X, Tang M, Keller K, Ludwig S, Moresco EMY, Beutler B, 2022 Jul Nat Commun 1 13 4136

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Zhang Z, Gallagher T, Scherer PE, Beutler B, 2020 May Proc. Natl. Acad. Sci. U.S.A. 21 117 11829-11835

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B 2016 Oct Proc. Natl. Acad. Sci. U.S.A. 42 113 E6418-E6426

Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2.

Jiang Y, Peng J, Song J, He J, Jiang M, Wang J, Ma L, Wang Y, Lin M, Wu H, Zhang Z, Gao D, Zhao Y, 2021 Nov Nat Metab 11 3 1569-1584

Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning.

Xu D, Lyon S, Bu CH, Hildebrand S, Choi JH, Zhong X, Liu A, Turer EE, Zhang Z, Russell J, Ludwig S, Mahrt E, Nair-Gill E, Shi H, Wang Y, Zhang D, Yue T, Wang KW, SoRelle JA, Su L, Misawa T, McAlpine W, Sun L, Wang J, Zhan X, Choi M, Farokhnia R, Sakla A, Schneider S, Coco H, Coolbaugh G, Hayse B, Mazal S, Medler D, Nguyen B, Rodriguez E, Wadley A, Tang M, Li X, Anderton P, Keller K, Press A, Scott L, Quan J, Cooper S, Collie T, Qin B, Cardin J, Simpson R, Tadesse M, Sun Q, Wise CA, Rios JJ, Moresco EMY, Beutler B, 2021 Jul Proc Natl Acad Sci U S A 28 118

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.

Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B, 2020 Apr J. Exp. Med. 4 217

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.

Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B, 2019 May Proc. Natl. Acad. Sci. U.S.A.

LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.

Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B, 2019 05 Science 6440 364

Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).

Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y 2018 Feb J Mol Cell Biol

mutation causes hyperphagic obesity, diabetes and hepatic steatosis.

Turer EE, San Miguel M, Wang KW, McAlpine W, Ou F, Li X, Tang M, Zang Z, Wang J, Hayse B, Evers B, Zhan X, Russell J, Beutler B 2018 Dec Dis Model Mech 12 11

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.

McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E 2018 12 Proc. Natl. Acad. Sci. U.S.A. 49 115 E11523-E11531

Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila.

Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y, 2018 10 J Mol Cell Biol 5 10 475-478

Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B 2017 Jun Proc. Natl. Acad. Sci. U.S.A. 26 114 E5197-E5206

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.

Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJ, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova JL, Puel A 2017 Feb Cell 5 168 789-800.e10

SUMO regulates somatic cyst stem cells maintenance and directly targets hedgehog pathway in adult Drosophila testis.

Lv X, Pan C, Zhang Z, Xia Y, Chen H, Zhang S, Guo T, Han H, Song H, Zhang L, Zhao Y 2016 Mar Development

The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-?B Signaling via Partial Degradation of the NF-?B Subunit p100.

Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z 2015 Jun J. Biol. Chem.

Real-time resolution of point mutations that cause phenovariance in mice.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B 2015 Jan Proc. Natl. Acad. Sci. U.S.A.

Kto-Skd complex can regulate ptc expression by interacting with Ci in Hedgehog signaling pathway.

Mao F, Yang X, Fu L, Lv X, Zhang Z, Wu W, Yang S, Zhou Z, Zhang L, Zhao Y 2014 Jun J. Biol. Chem.

Hedgehog in the Drosophila testis niche: what does it do there?

Zhang Z, Pan C, Zhao Y, 2013 Sep Protein Cell 9 4 650-5

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling.

Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, Wu W, Zhou Z, Zhang L, Zhao Y, 2013 Sep J. Cell. Sci. Pt 18 126 4230-8

Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.

Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, Liu F, Zhang L, Zhao Y, 2013 Nov J. Cell Biol. 4 203 575-83

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D 2013 Nov PLoS Biol. 11 11 e1001721

Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts is Essential for High Hh Activity Transduction.

Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y 2013 Mar J. Biol. Chem.

Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

Zhang Z, Lv X, Yin WC, Zhang X, Feng J, Wu W, Hui CC, Zhang L, Zhao Y 2013 Jun Dev. Cell 6 25 636-44

Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism.

Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L, Zhao Y, Zhou Z 2013 Feb Structure

Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis.

Zhang Z, Lv X, Jiang J, Zhang L, Zhao Y 2013 Feb Cell Res.