Publications

Milde T, Fangusaro J, Fisher MJ, Hawkins C, Rodriguez FJ, Tabori U, Witt O, Zhu Y, Gutmann DH. Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation. Neuro Oncol 2023 Nov 2;25(11):1920-1931. PMID:37738646


Treisman D, Li Y, Zhu Y. Stem-Like Cell Populations, p53-Pathway Activation and Mechanisms of Recurrence in Sonic Hedgehog Medulloblastoma. Neuromolecular Med 2022 Mar;24(1):13-17. PMID:34165693


Zhu Y, Zheng W, Jecrois ES, Pierce BR, Treisman DM. A therapeutic window for preventive therapy in NF1-associated optic pathway glioma. Mol Cell Oncol 2021 Nov 30;8(6):1989262. PMID:35419473


Jecrois ES, Zheng W, Bornhorst M, Li Y, Treisman DM, Muguyo D, Huynh S, Andrew SF, Wang Y, Jiang J, Pierce BR, Mao H, Krause MK, Friend A, Nadal-Nicolas F, Stasheff SF, Li W, Zong H, Packer RJ, Zhu Y. Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Dev Cell 2021 Oct 25 56(20):2871-2885.e6. PMID:34428430


Li Y, Li B, Li W, Wang Y, Akgül S, Treisman DM, Heist KA, Pierce BR, Hoff B, Ho CY, Ferguson DO, Rehemtulla A, Zheng S, Ross BD, Li JZ, Zhu Y. Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution. Nat Commun 2020 Jul 22 11(1):3669. PMID:32699356


Treisman DM, Li Y, Pierce BR, Li C, Chervenak AP, Tomasek GJ, Lozano G, Zheng X, Kool M, Zhu Y. Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence. Neurooncol Adv. 2019 May-Dec;1(1):ydz027. PMID:31763624


Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y. Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep 2018 Jul 10 24(2):463-478.e5. PMID:29996106


Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. Elife 2014 Dec 23 3():. PMID:25535838


Wang Y, Kim E, Wang X, Novitch BG, Yoshikawa K, Chang LS, Zhu Y. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell 2012 Aug 17 150(4):816-30. PMID:22901811


Tan M, Zhao Y, Kim SJ, Liu M, Jia L, Saunders TL, Zhu Y, Sun Y. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell 2011 Dec 13;21(6):1062-76. PMID:22118770


Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 2009 Jun 2 15(6):514-26. PMID:19477430


Zheng H, Chang L, Patel N, Yang J, Lowe L, Burns DK, Zhu Y. Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation. Cancer Cell 2008 Feb 13(2):117-28. PMID:18242512


Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, Conway SJ, Parada LF, Zhu Y, Morrison SJ. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 2008 Feb;13(2):129-40. PMID:18242513


Romero MI, Lin L, Lush ME, Lei L, Parada LF, Zhu Y. Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci 2007 Feb 21;27(8):2124-34. PMID:17314307


Zhu Y, Harada T, Liu L, Lush ME, Guignard F, Harada C, Burns DK, Bajenaru ML, Gutmann DH, Parada LF. Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development 2005 Dec;132(24):5577-88. PMID:16314489


Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, Mason RP, Messing A, Parada LF. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 2005 Aug 8(2):119-30. PMID:16098465


Parada LF, Kwon CH, Zhu Y. Modeling neurofibromatosis type 1 tumors in the mouse for therapeutic intervention. Cold Spring Harb Symp Quant Biol 2005;70:173-6. PMID:16869751


Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA. Nf1 has an essential role in endothelial cells. Nat Genet 2003 Jan;33(1):75-9. PMID:12469121


Zhu Y, Parada LF. The molecular and genetic basis of neurological tumours. Nat Rev Cancer 2002 Aug;2(8):616-26. PMID:12154354


Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 2002 May 3 296(5569):920-2. PMID:11988578


Zhu Y, Parada LF. A particular GAP in mind. Nat Genet 2002 Apr;27(4):354-5. PMID:11279509


Zhu Y, Romero MI, Ghosh P, Ye Z, Charnay P, Rushing EJ, Marth JD, Parada LF. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 2001 Apr 1;15(7):859-76. PMID:11297510


Zhu Y, Parada LF. Neurofibromin, a tumor suppressor in the nervous system. Exp Cell Res 2001 Mar 10;264(1):19-28. PMID:11237520


Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998 Sep 18 94(6):703-14. PMID:9753318