Post-Doctoral Research Fellows
The laboratory of Carlos L. Arteaga, M.D., at the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern is recruiting Postdoctoral Research Fellows.
- Discovery of mechanisms of resistance to antiestrogen therapy in breast cancer
- Genomic profiling of drug-resistant ER+ and triple-negative breast cancer
- Mechanism of action of gain of function oncogenes in breast cancer and their use as predictive biomarkers of response (and resistance) to targeted therapies
- Mechanisms of action of and resistance to rational combinations of targeted therapies in breast cancer (focus on PI3K/AKT, mutant ERBB receptors, ERa, FGFR, CDK4)
Methods include CRISPR screens, gain-of-function ORF whole genome screens, next-gen DNA sequencing, single cell RNAseq, structural modeling, small animal functional imaging, molecular profiling of primary tumors (whole exome, RNA-seq), statistical analysis, and discovery focused on studies with cell lines and xenografts (from cell lines and patient-derived) using conditional shRNAs and targeted therapies in clinical development both in vitro and in vivo and primary tumors from patients in clinical trials with targeted therapies.
Applicants with a Ph.D., M.D., or M.D./Ph.D. and a strong background in molecular & cell biology and genomics with a strong interest in translational research are encouraged to apply.
Please forward your CV and names of three references to:
Carlos L. Arteaga, M.D.
Director, UTSW Harold C. Simmons Cancer Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8590
Assistant: Paula Ribeiro