Publications

Corrigendum: Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, DePinho RA, Bonni A 2025 Feb Genes & development 39 299

Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing(Nature, 10.1038/nature01385)

Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA 2025 Nature

Spatially Precise and Minimally Invasive Delivery of Peptides to the Spinal Cord for Behavior Modulation

Leong TW, Gao Z, David ET, Li X, Cai Q, Mwirigi JM, Zhang T, Giannotta M, Dejana E, Wiggins J, Krishnagiri S, Bachoo RM, Ge X, Price TJ, Qin Z 2024 Dec ACS Nano 18 34720-34729

Erratum: Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis (Epidermal growth factor receptor and Ink4a/Arf (2002) 1(3) (269–277), (S1535610802000466), (10.1016/S1535-6108(02)00046-6))

Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA 2024 Dec Cancer Cell 42 2124

Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration

Myers BL, Brayer KJ, Paez-Beltran LE, Villicana E, Keith MS, Suzuki H, Newville J, Anderson RH, Lo Y, Mertz CM, Kollipara RK, Borromeo MD, Lu QR, Bachoo RM, Johnson JE, Vue TY 2024 Dec Nature communications 15

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

Xiong H, Wilson BA, Ge X, Gao X, Cai Q, Xu X, Bachoo R, Qin Z 2024 Feb Nano Letters 24 1570-1578

Optical Modulation of the Blood–Brain Barrier for Glioblastoma Treatment

Cai Q, Fan H, Li X, Giannotta M, Bachoo R, Qin Z 2024 Jan Bio-protocol 14

Live Mapping of the Brain Extracellular Matrix and Remodeling in Neurological Disorders

Ge X, Xu X, Cai Q, Xiong H, Xie C, Hong Y, Gao X, Yao Y, Bachoo R, Qin Z 2024 Jan Small Methods 8

Glioblastoma

Maher EA, Bachoo RM 2024 Jan 2 215-227

Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment

Cai Q, Li X, Xiong H, Fan H, Gao X, Vemireddy V, Margolis R, Li J, Ge X, Giannotta M, Hoyt K, Maher E, Bachoo R, Qin Z 2023 Dec Nature communications 14

Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution

Zhang H, Yu X, Ye J, Li H, Hu J, Tan Y, Fang Y, Akbay E, Yu F, Weng C, Sankaran VG, Bachoo RM, Maher E, Minna J, Zhang A, Li B 2023 Oct Cancer Cell 41 1788-1802.e10

ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

Blandin AF, Giglio R, Graham MS, Garcia G, Malinowski S, Woods JK, Ramkissoon S, Ramkissoon L, Dubois F, Schoolcraft K, Tsai J, Wang D, Jones R, Vogelzang J, Pelton K, Becker S, Watkinson F, Sinai C, Cohen EF, Booker MA, Tolstorukov MY, Haemels V, Goumnerova L, Wright K, Kieran M, Fehnel K, Reardon D, Tauziede-Espariat A, Lulla R, Carcamo B, Chaleff S, Charest A, De Smet F, Ligon AH, Dubuc A, Pages M, Varlet P, Wen PY, Alexander BM, Chi S, Alexandrescu S, Kittler R, Bachoo R, Bandopadhayay P, Beroukhim R, Ligon KL 2023 Jul Clinical Cancer Research 29 2651-2667

Mechanobiological modulation of blood-brain barrier permeability by laser stimulation of endothelial-targeted nanoparticles

Li X, Cai Q, Wilson BA, Fan H, Dave H, Giannotta M, Bachoo R, Qin Z 2023 Jan Nanoscale 15 3387-3397

Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas

Ijare OB, Hambarde S, Brasil Da Costa FH, Lopez S, Sharpe MA, Helekar SA, Hangel G, Bogner W, Widhalm G, Bachoo RM, Baskin DS, Pichumani K 2022 Apr Neuro-oncology 24 556-568

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S 2022 Jan Cell Metabolism 34 90-105.e7

SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides

Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT 2021 Dec Journal of Biochemistry 170 699-711

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles

Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z 2021 Nov Nano Letters 21 9805-9815

Large animal models of glioma: Current status and future prospects

HICKS WH, BIRD CE, PERNIK MN, HAIDER AS, DOBARIYA A, ABDULLAH KG, AOUN SG, BENTLEY RT, COHEN-GADOL AA, BACHOO RM, MICKEY BE, PASCUAL JM, EL AHMADIEH TY 2021 Nov Anticancer Research 41 5343-5353

Probing Cerebral Metabolism with Hyperpolarized 13C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound

Hackett EP, Shah BR, Cheng B, Lague E, Vemireddy V, Mendoza M, Bing C, Bachoo RM, Billingsley KL, Chopra R, Park JM 2021 Aug ACS Chemical Neuroscience 12 2820-2828

Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain

Ahmed MS, Wang P, Nhi Nguyen NU, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES 2021 Mar Proceedings of the National Academy of Sciences of the United States of America 118

Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate: Potential role in clinical decision making

Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Pena S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE, Park JM 2021 Jan Neuro-Oncology Advances 3

ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

Vue TY, Kollipara RK, Borromeo MD, Smith T, Mashimo T, Burns DK, Bachoo RM, Johnson JE 2020 Dec GLIA 68 2613-2630

In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients

Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, Choi C 2020 Sep Magnetic resonance in medicine 84 1152-1160

Mechanical regulation of glycolysis via cytoskeleton architecture

Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G 2020 Feb Nature 578 621-626

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SG, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge Wp 2020 Feb Cell Reports 30 2489-2500.e5

Differences in creep response of GBM cells migrating in confinement

Khan I, Bui L, Bachoo R, Kim YT, Chuong CJ 2020 Jan International Biomechanics 7 44-57

Glioblastoma

Maher EA, Bachoo RM 2020 Jan 173-182

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LM, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT 2019 Aug Nature cell biology 21 1003-1014

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM 2019 Science translational medicine 11

Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high-grade gliomas

Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S 2019 Cancer research 79 3749-3761

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo R, Maher EA 2018 Nov Cell Metabolism 28 793-800.e2

Measurement of 13C turnover into glutamate and glutamine pools in brain tumor patients

Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA 2017 Nov FEBS Letters 591 3548-3554

Label-free optical detection of action potential in mammalian neurons

Batabyal S, Satpathy S, Bui L, Kim YT, Mohanty S, Bachoo R, Davé DP 2017 Aug Biomedical Optics Express 8 3700-3713

Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis

Richardson TE, Snuderl M, Serrano J, Karajannis MA, Heguy A, Oliver D, Raisanen JM, Maher EA, Pan E, Barnett S, Cai C, Habib AA, Bachoo RM, Hatanpaa KJ 2017 May Journal of Neuro-Oncology 133 183-192

Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles

Peng C, Gao X, Xu J, du B, Ning X, Tang S, Bachoo RM, Yu M, Ge WP, Zheng J 2017 Apr Nano Research 10 1366-1376

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM 2017 Jan Cell Reports 18 961-976

Prospective longitudinal analysis of 2-hydroxyglutarate magnetic resonance spectroscopy identifies broad clinical utility for the management of patients with IDH-mutant glioma

Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA 2016 Nov Journal of Clinical Oncology 34 4030-4039

Hepatic gluconeogenesis influences 13C enrichment in lactate in human brain tumors during metabolism of [1,2-13C]acetate

Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA 2016 Jul Neurochemistry International 97 133-136

Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement

Bui L, Hendricks A, Wright J, Chuong CJ, Davé D, Bachoo R, Kim YT 2016 May Scientific reports 6

Conditions for 13C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas

Pichumani K, Mashimo T, Baek HM, Ratnakar J, Mickey B, DeBerardinis RJ, Maher EA, Bachoo RM, Malloy CR, Kovacs Z 2015 Jun Analytical biochemistry 481 4-6

Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo

Madan A, Ganji SK, An Z, Choe KS, Pinho MC, Bachoo RM, Maher EM, Choi C 2015 Jun Magnetic resonance in medicine 73 2094-2099

SOX2 reprograms resident astrocytes into neural progenitors in the adult brain

Niu W, Zang T, Smith DK, Vue TY, Zou Y, Bachoo R, Johnson JE, Zhang CL 2015 May Stem Cell Reports 4 780-794

DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification

Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S 2015 Feb Oncogene 34 1064-1072

1H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors

Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C 2015 Jan NMR in biomedicine 28 108-115

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, Deberardinis RJ, Tu BP, Maher EA, Bachoo RM 2014 Dec Cell 159 1603-1614

Glioblastoma

Maher EA, Bachoo RM 2014 Nov 909-917

In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T

Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA 2014 Aug Magnetic resonance in medicine 72 316-323

In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma

Sagiyama K, Mashimo T, Togao O, Vemireddy V, Hatanpaa KJ, Maher EA, Mickey BE, Pan E, Sherry AD, Bachoo RM, Takahashi M 2014 Mar Proceedings of the National Academy of Sciences of the United States of America 111 4542-4547

High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas

Hatanpaa KJ, Hu T, Vemireddy V, Foong C, Raisanen JM, Oliver D, Hiemenz MC, Burns DK, White CL, Whitworth LA, Mickey B, Stegner M, Habib AA, Fink K, Maher EA, Bachoo RM 2014 Mar Journal of Neuro-Oncology 117 183-189

Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma

Gil Del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S 2014 Clinical Cancer Research 20 1235-1248

A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

Choi C, Ganji S, Hulsey K, Madan A, Kovacs Z, Dimitrov I, Zhang S, Pichumani K, Mendelsohn D, Mickey B, Malloy C, Bachoo R, Deberardinis R, Maher E 2013 Oct NMR in biomedicine 26 1242-1250

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang CL 2013 Oct Nature cell biology 15 1164-1175

In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis

Decarolis NA, Mechanic M, Petrik D, Carlton A, Ables JL, Malhotra S, Bachoo R, Götz M, Lagace DC, Eisch AJ 2013 Aug Hippocampus 23 708-719

Proliferation and migration of tumor cells in tapered channels

Wan Y, Tamuly D, Allen PB, Kim YT, Bachoo R, Ellington AD, Iqbal SM 2013 Aug Biomedical Microdevices 15 635-643

Progenitor Cell Line (hPheo1) Derived from a Human Pheochromocytoma Tumor

Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW 2013 Jun PloS one 8

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Panditaa TK 2013 Mar Molecular and cellular biology 33 1210-1222

Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK 2013 Molecular and cellular biology 33 3390

Erratum: Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo (Cell Metabolism (2012) 16 (394-406))

Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM 2012 Nov Cell Metabolism 16 686

Metabolism of [U-13C]glucose in human brain tumors in vivo

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, Deberardinis RJ 2012 Nov NMR in biomedicine 25 1234-1244

Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors

Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen JM, Sun X, Mickey BE, Choi C, Takahashi M, Togao O, Pascual JM, DeBerardinis RJ, Maher EA, Malloy CR, Bachoo R 2012 Oct NMR in biomedicine 25 1177-1186

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

Fenton TR, Nathanson D, Ponte De Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo S, Uno M, Del Mar Inda M, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB 2012 Aug Proceedings of the National Academy of Sciences of the United States of America 109 14164-14169

Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

Asghar W, Wan Y, Ilyas A, Bachoo R, Kim YT, Iqbal SM 2012 Jul Lab on a Chip 12 2345-2352

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, DeBerardinis RJ, Bachoo RM 2012 Jun Cell Metabolism 15 827-837

2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo R, Maher EA 2012 Apr Nature medicine 18 624-629

Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology

Wan Y, Mahmood MA, Li N, Allen PB, Kim YT, Bachoo R, Ellington AD, Iqbal SM 2012 Feb Cancer 118 1145-1154

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors

Fisher D, Xing B, Dill J, Li H, Hoang HH, Zhao Z, Yang XL, Bachoo R, Cannon S, Longo FM, Sheng M, Silver J, Li S 2011 Oct Journal of Neuroscience 31 14051-14066

ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability

Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA 2011 Sep Oncogene 30 3745-3754

MicroRNA-146a inhibits glioma development by targeting Notch1

Mei J, Bachoo R, Zhang CL 2011 Sep Molecular and cellular biology 31 3584-3592

Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: Application in brain tumors

Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA 2011 Sep Magnetic resonance in medicine 66 609-618

Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression

Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo R, Hsieh J 2011 Apr Differentiation 81 233-242

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY 2011 Mar Journal of Clinical Investigation 121 905-917

Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice

Kumar R, Hunt CR, Gupta A, Nannepaga S, Pandita RK, Shay JW, Bachoo R, Ludwig T, Burns DK, Pandita TK 2011 Mar Proceedings of the National Academy of Sciences of the United States of America 108 3636-3641

Erratum: Surface-immobilized aptamers for cancer cell isolation and microscopic cytology (Cancer Research (2010) 70 (9371-80))

Wan Y, Kim YT, Li N, Cho SK, Bachoo R, Ellington AD, Iqbal SM 2011 Jan Cancer research 71 626

Surface-immobilized aptamers for cancer cell isolation and microscopic cytology

Wan Y, Kim YT, Li N, Cho SK, Bachoo R, Ellington AD, Iqbal SM 2010 Nov Cancer research 70 9371-9380

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

Inda MD, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, DePinho RA, Cavenee W, Furnari F 2010 Aug Genes and Development 24 1731-1745

Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks

Camacho CV, Mukherjee B, McEllin B, Ding LH, Hu B, Habib AA, Xie XJ, Nirodi CS, Saha D, Story MD, Balajee AS, Bachoo RM, Boothman DA, Burma S 2010 Jul Carcinogenesis 31 1889-1896

PTEN loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-Ribose) polymerase inhibitors

McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, Burma S 2010 Jul Cancer research 70 5457-5464

Glioblastoma cellsrequire glutamate dehydrogenase to survive impairments of glucose metabolism or akt signaling (Cancer Research (2009) 69, (7986-7993))

Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ 2010 Feb Cancer research 70 1275

A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons

Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S 2010 Jan Journal of Neuroscience 30 963-972

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

Marian CO, Cho SK, Mcellin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM 2010 Jan Clinical Cancer Research 16 154-163

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

Chendong Y, Sudderth J, Tuyen D, Bachoo RG, McDonald JG, DeBerardinis RJ 2009 Oct Cancer research 69 7986-7993

EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma

Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S 2009 May Cancer research 69 4252-4259

The receptor interacting protein 1 inhibits p53 induction through NF-KB activation and confers a worse prognosis in glioblastoma

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA 2009 Apr Cancer research 69 2809-2816

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

De La Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, DePinho RA, Bonni A 2008 Feb Genes and Development 22 449-462

Functional skeletal muscle regeneration from differentiating embryonic stem cells

Darabi R, Gehlbach K, Bachoo RM, Kamath S, Osawa M, Kamm KE, Kyba M, Perlingeiro RC 2008 Feb Nature medicine 14 134-143

Malignant astrocytic glioma: Genetics, biology, and paths to treatment

Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK 2007 Nov Genes and Development 21 2683-2710

Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma

Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, DePinho RA, Anderson DJ, Stiles CD, Rowitch DH 2007 Feb Neuron 53 503-517

Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111))

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L 2007 Feb Genes and Development 21 481

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L 2007 Jan Genes and Development 21 98-111

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM 2006 Oct Cell 127 397-408

PCAF modulates PTEN activity

Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB 2006 Sep Journal of Biological Chemistry 281 26562-26568

Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy

Dickie R, Bachoo RM, Rupnick MA, Dallabrida SM, DeLoid GM, Lai J, DePinho RA, Rogers RA 2006 Jul Microvascular Research 72 20-26

Erratum: Molecular diversity of astrocytes with implications for neurological disorders (Proceedings of the National Academy of Sciencs of the United States of America (June 1, 2004) 101, 22 (8384-8389))

Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA 2004 Jul Proceedings of the National Academy of Sciences of the United States of America 101

Molecular diversity of astrocytes with implications for neurological disorders

Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA 2004 Jun Proceedings of the National Academy of Sciences of the United States of America 101 8384-8389

Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity

Kang HJ, Choi YS, Hong SB, Kim KW, Woo RS, Won SJ, Kim EJ, Jeon HK, Jo SY, Kim TK, Bachoo R, Reynolds IJ, Gwag BJ, Lee HW 2004 Feb Journal of Neuroscience 24 1280-1287

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA 2003 Feb Nature 421 643-648

Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis

Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA 2002 Apr Cancer Cell 1 269-277

Malignant glioma: Genetics and biology of a grave matter

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA 2001 Genes and Development 15 1311-1333

Microsurgical C-2 ganglionectomy for chronic intractable occipital pain

Lozano AM, Vanderlinden G, Bachoo R, Rothbart P 1998 Sep Journal of neurosurgery 89 359-365

In vitro and in vivo evidence of neurotensin release from preganglionic axon terminals in the stellate ganglion of the cat

Maher E, Bachoo B, Polosa C 1994 Mar Brain Research 640 131-135

Role of neuron soma firing in the restoration of neurotensin store in sympathetic preganglionic neuron terminals after stimulus-evoked depletion

Maher E, Bachoo B, Polosa C 1994 Mar Brain Research 640 126-130