Publications

Featured Publications

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity.

Sahoo SS, Ramanand SG, Gao Y, Abbas A, Kumar A, Cuevas IC, Li HD, Aguilar M, Xing C, Mani RS, Castrillon DH, 2022 Jun J Clin Invest 12 132

Reliable Identification of Endometrial Precancers Through Combined Pax2, ?-Catenin, and Pten Immunohistochemistry.

Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, 2021 Sep Am J Surg Pathol

Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.

Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH, 2021 Jan J Pathol

Histopathologic diagnosis of endometrial precancers: Updates and future directions.

Chen H, Strickland AL, Castrillon DH, 2021 Dec Semin Diagn Pathol

A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.

Li HD, Lu C, Zhang H, Hu Q, Zhang J, Cuevas IC, Sahoo SS, Aguilar M, Maurais EG, Zhang S, Wang X, Akbay EA, Li GM, Li B, Koduru P, Ly P, Fu YX, Castrillon DH, 2020 Jul JCI Insight 14 5

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.

Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH, 2019 Nov Proc. Natl. Acad. Sci. U.S.A.

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load.

Li HD, Cuevas I, Zhang M, Lu C, Alam MM, Fu YX, You MJ, Akbay EA, Zhang H, Castrillon DH 2018 Aug J. Clin. Invest. 9 128 4179-4191

Somatic LKB1 mutations promote cervical cancer progression.

Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH 2009 PLoS ONE 4 4 e5137

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA 2007 Jan Cell 2 128 309-23

PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia.

Strickland AL, Rivera G, Lucas E, John G, Cuevas I, Castrillon DH 2018 Sep Int. J. Gynecol. Pathol.

Control of Oocyte Reawakening by Kit.

Saatcioglu HD, Cuevas I, Castrillon DH 2016 Aug PLoS Genet. 8 12 e1006215

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.

Peña CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH 2015 Sep J. Clin. Invest.

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.

Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH 2012 Jun Oncogene

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.

Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH 2010 Mar-Apr Dis Model Mech 3-4 3 181-93