A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis.
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FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity.
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2022 Jun
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Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies.
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2021 Sep
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Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.
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2021 Jan
J Pathol
A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.
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2020 Jul
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Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.
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2019 Nov
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Somatic LKB1 mutations promote cervical cancer progression.
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β-catenin, PAX2, and PTEN Aberrancy Across the Spectrum of Endometrioid Ovarian Lesions.
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2024 Jul
Int J Gynecol Pathol
Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden.
Zhu M, Kim J, Deng Q, Ricciuti B, Alessi JV, Eglenen-Polat B, Bender ME, Huang HC, Kowash RR, Cuevas I, Bennett ZT, Gao J, Minna JD, Castrillon DH, Awad MM, Xu L, Akbay EA,
2023 Sep
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Utility of a PAX2, PTEN, and β-catenin Panel in the Diagnosis of Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia in Endometrial Polyps.
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2023 Jun
Am J Surg Pathol
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.
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2020 Sep
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LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.
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Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.
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