Genetic tools: We have generated several genetically-engineered alleles with broad uses in biomedical research, including the 2nd-generation endometrial driver, BAC-Sprr2f-Cre, and LSL-PoleP286R.
Carcinosarcoma and Fbxw7: Carcinosarcoma is the most aggressive and least understood variant of endometrial cancer, distinguished from usual endometrial cancers by admixed malignant epithelial and mesenchymal components (carcinoma and sarcoma).
POLE mutations and endometrial cancer: About 10% of endometrial cancers are initiated by a mutation (most frequently P286R) in polymerase epsilon (encoded by the POLE gene).
Early diagnosis and prevention of endometrial cancer: The diagnosis of endometrial precancer (endometrioid intraepithelial neoplasia/EIN) remains a challenging area, with variable criteria and frequent disagreements even among expert gynecologic pathologists, potentially leading to under/overtreatment.