Publications

Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries.

Harris AK, Nelson AT, Watson D, Mallinger PHR, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KAP, 2025 May Cancer 9 131 e35862

One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma.

Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KAP, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD, 2025 May Clin Cancer Res

Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor.

Tiburcio PDB, Chen K, Xu L, Chen KS, 2025 May Cell Rep Med 5 6 102133

PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor.

Tiburcio PDB, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS, 2025 Jun Pediatr Blood Cancer e31852

Pleuropulmonary blastoma and DICER1-related tumor predisposition: from clinicopathologic observations to clinical trial.

Nelson AT, Chen KS, Schultz KAP, 2025 Feb Curr Opin Pediatr 1 37 48-55

Germline pathogenic DROSHA variants are linked to pineoblastoma and Wilms tumor predisposition.

Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Saulnier Sholler G, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Williams Parsons D, Plon SE, Schultz KAP, Onel K, 2025 Feb Clin Cancer Res

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.

Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS, 2025 Apr Genes Dev

Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell Tumor.

Nelson AT, Watson D, Chen KS, Olson DR, Stall JN, Devins KM, Young RH, Kamihara J, Mallinger PHR, Kim J, Hatton JN, Messinger YH, Frazier AL, Stewart DR, Schneider DT, Harris AK, Dehner LP, Hill DA, Schultz KAP, 2025 Apr JCO Precis Oncol 9 e2400902

DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Schultz KAP, Nelson AT, Mallinger PHR, Harris AK, Kamihara J, Baldinger S, Chen KS, Pond D, Hatton JN, Dybvik A, Mitchell SG, Perrino MR, Ben-Ami T, Kachanov D, Su Y, Duan C, Olson DR, Watson D, Field AL, Harney LA, Garrity Carr A, Frazier AL, Schneider DT, Wilson DB, MacFarland SP, Schoettler PJ, Bauer AJ, Dehner LP, Hill DA, Stewart DR, Messinger YH, 2024 Oct Clin Cancer Res

Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry.

Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KAP, 2024 May Pediatr Blood Cancer e31090

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.

Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP, 2024 Apr Gynecol Oncol 186 117-125

DROSHA regulates mesenchymal gene expression in Wilms tumor.

Tiburcio PDB, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Xu L, Chen KS, 2024 Apr Mol Cancer Res

Intronic Germline DICER1 Variants in Patients With Sertoli-Leydig Cell Tumor.

Fraire CR, Mallinger PR, Hatton JN, Kim J, Dickens DS, Argenta PA, Milanovich S, Hartshorne T, Carey DJ, Haley JS, Urban G, Lee J, Hill DA, Stewart DR, Schultz KAP, Chen KS, 2023 Sep JCO Precis Oncol 7 e2300189

Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence.

Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJM, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LHJ, Draper BW, Frazier AL, Amatruda JF, 2023 May Nat Commun 1 14 2636

Ectopic PLAG1 induces muscular dystrophy in the mouse.

Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen K, Burns DK, Zheng Y, 2023 Jul Biochem Biophys Res Commun 665 159-168

Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains.

Medvedev KE, Schaeffer RD, Chen KS, Grishin NV, 2023 Jul Sci Rep 1 13 11988

Children's Oncology Group's 2023 blueprint for research: Rare tumors.

Schultz KAP, Chintagumpala M, Piao J, Chen KS, Gartrell R, Christison-Lagay E, Berry JL, Shah R, Laetsch TW, 2023 Jul Pediatr Blood Cancer e30574

Rare Tumors: Opportunities and challenges from the Children's Oncology Group perspective.

Schultz KAP, Chintagumpala M, Piao J, Chen KS, Shah R, Gartrell RD, Christison-Lagay E, Pashnakar F, Berry JL, O'Neill AF, Vasta LM, Flynn A, Mitchell SG, Seynnaeve BK, Rosenblum J, Potter SL, Kamihara J, Rodriguez-Galindo C, Hawkins DS, Laetsch TW, 2023 Dec EJC Paediatr Oncol 2

Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.

Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D, 2022 Feb Pediatr Blood Cancer 2 69 e29451

Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis And Tumor Models.

Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D, 2022 Feb J Pediatr Hematol Oncol

Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis.

Medvedev KE, Savelyeva AV, Chen KS, Bagrodia A, Jia L, Grishin NV, 2022 Cancer Inform 21 11769351221132634

Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1

Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF 2018 Jul Genes Dev.

EGF Receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors.

Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF 2018 Feb Mol. Cancer Ther.

A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma.

Chen KS, Kwon WS, Kim J, Heo SJ, Kim HS, Kim HK, Kim SH, Lee WS, Chung HC, Rha SY, Hwang TH 2016 Sep Cold Spring Harb Mol Case Stud 5 2 a000992

p53 genes function to restrain mobile elements.

Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM 2015 Dec Genes Dev.

Invited reply to amikacin ototoxicity in children with cancer: the problem is the administration schedule.

Chen K, Bach A, Shoup A, Winick N 2014 Feb Pediatr Blood Cancer 2 61 191

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF 2014 Nat Commun 2 4802

Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides.

Chen KS, Bach A, Shoup A, Winick NJ 2013 Jun Pediatr Blood Cancer

A big catch for germ cell tumour research.

Chen KS, Amatruda JF 2013 Apr PLoS Genet. 4 9 e1003481

DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors.

Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN 2013 BMC Cancer 1 13 313

Hemolytic non-uremic syndrome.

Chen KS, Neunert CE, Crary SE, Buchanan GR 2012 Jul Pediatr Blood Cancer 1 59 167-9

A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse.

Singleton K, Parvaze N, Dama KR, Chen KS, Jennings P, Purtic B, Sjaastad MD, Gilpin C, Davis MM, Wülfing C 2006 Oct J. Immunol. 7 177 4402-13

Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.

Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA 2001 May Blood 10 97 3146-51