Publications

Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults

Flores-Toro J, Jagu S, Smith M, Shern J, Hawkins DS, Mardis ER, Rudzinski E, Alonzo TA, Beeles T, Ramirez N, Thomas DL, Cottrell CE, Parbhoo K, Janeway KA, Leary S, Fouladi M, Oberoi S, Venkatramani R, Irwin M, Laetsch TW, Chen KS, Bailey K, Davis JL, Sullivan MB, Boja E, Lowy D, Guidry Auvil JM, Wideman B, Kibbe W, Doroshow J, Reaman GH 2026 Feb Journal of the National Cancer Institute 118 199-204

Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee

Englum BR, Piao J, Younis L, Baertschiger RM, Chen KS, Christison-Lagay E, Dholaria H, Gartrell R, Hicks MJ, Kamihara J, Mitchell SG, Orjuela-Grimm M, Pashankar F, Potter SL, Aldrink JH, Rosenblum J, Sargen MR, Schultz KA, Seynnaeve BK, Wedekind M, Laetsch TW 2026 Feb Pediatric Blood and Cancer 73

RAS pathway targeted therapy in patients with DICER1-associated sarcomas

Zhang L, Mallinger PH, Zhou S, Makri SC, Gross JM, Lucas CH, Zou YS, Mize W, Olson DR, Munnikhuysen SR, Rawwas J, Messinger Y, Chen KS, Schultz KA, Pratilas CA 2025 Dec npj Precision Oncology 9

Feasibility of Atezolizumab in Combination With Chemotherapy for Children With Relapsed or Refractory Solid Tumors

Campbell ME, Stutzman S, Primeaux S, Sida D, Lee M, Shah AT, Sadanand A, Sokol E, Collins NB, Turpin B, Navai S, Albert K, Laetsch TW, Rakheja D, Chen KS, Gerber DE, Koh AY 2025 Dec Pediatric Blood and Cancer 72

PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor

Tiburcio PD, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS 2025 Sep Pediatric Blood and Cancer 72

One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma

Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KA, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD 2025 Aug Clinical Cancer Research 31 3124-3132

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS 2025 Jun Genes and Development 39 727-750

Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor

Tiburcio PD, Chen K, Xu L, Chen KS 2025 May Cell Reports Medicine 6

Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries

Harris AK, Nelson AT, Watson D, Mallinger PH, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KA 2025 May Cancer 131

Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition

Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Sholler GS, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Parsons DW, Plon SE, Schultz KA, Onel K 2025 Apr Clinical Cancer Research 31 1491-1503

Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell Tumor

Nelson AT, Watson D, Chen KS, Olson DR, Stall JN, Devins KM, Young RH, Kamihara J, Mallinger PH, Kim J, Hatton JN, Messinger YH, Frazier AL, Stewart DR, Schneider DT, Harris AK, Dehner LP, Hill DA, Schultz KA 2025 Apr JCO Precision Oncology 9

Pleuropulmonary blastoma and DICER1 -related tumor predisposition: From clinicopathologic observations to clinical trial

Nelson AT, Chen KS, Schultz KA 2025 Feb Current opinion in pediatrics 37 48-55

DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies

Schultz KA, Nelson AT, Mallinger PH, Harris AK, Kamihara J, Baldinger S, Chen KS, Pond D, Hatton JN, Dybvik AG, Mitchell SG, Perrino MR, Ben-Ami T, Kachanov D, Su Y, Duan C, Olson DR, Watson D, Field AL, Harney LA, Carr AG, Frazier AL, Schneider DT, Wilson DB, MacFarland SP, Schoettler PJ, Bauer AJ, Dehner LP, Hill DA, Stewart DR, Messinger YH 2024 Dec Clinical Cancer Research 30 5681-5692

DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor

Tiburcio PD, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Xu L, Chen KS 2024 Aug Molecular Cancer Research 22 711-720

Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry

Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KA 2024 Aug Pediatric Blood and Cancer 71

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries

Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PH, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KA 2024 Jul Gynecologic oncology 186 117-125

Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence

Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJ, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LH, Draper BW, Frazier AL, Amatruda JF 2023 Dec Nature communications 14

Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains

Medvedev KE, Schaeffer RD, Chen KS, Grishin NV 2023 Dec Scientific reports 13

Rare tumors: Opportunities and challenges from the Children's Oncology Group perspective

Schultz KA, Chintagumpala M, Piao J, Chen KS, Shah R, Gartrell RD, Christison-Lagay E, Pashnakar F, Berry JL, O'Neill AF, Vasta LM, Flynn A, Mitchell SG, Seynnaeve BK, Rosenblum J, Potter SL, Kamihara J, Rodriguez-Galindo C, Hawkins DS, Laetsch TW 2023 Dec EJC Paediatric Oncology 2

Intronic Germline DICER1 Variants in Patients with Sertoli-Leydig Cell Tumor

Fraire CR, Mallinger PR, Hatton JN, Kim J, Dickens DS, Argenta PA, Milanovich S, Hartshorne T, Carey DJ, Haley JS, Urban G, Lee J, Hill DA, Stewart DR, Schultz KA, Chen KS 2023 Oct JCO Precision Oncology 7

Children's Oncology Group's 2023 blueprint for research: Rare tumors

Author Collaboration tC, Schultz KA, Chintagumpala M, Piao J, Chen KS, Gartrell R, Christison-Lagay E, Berry JL, Shah R, Laetsch TW 2023 Sep Pediatric Blood and Cancer 70

Ectopic PLAG1 induces muscular dystrophy in the mouse

Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen K, Burns DK, Zheng Y 2023 Jul Biochemical and Biophysical Research Communications 665 159-168

Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation

Hatton JN, Frone MN, Cox HC, Crowley SB, Hiraki S, Yokoyama NN, Abul-Husn NS, Amatruda JF, Anderson MJ, Bofill-De Ros X, Carr AG, Chao EC, Chen KS, Gu S, Higgs C, Machado J, Ritter D, Schultz KA, Soper ER, Wu MK, Mester JL, Kim J, Foulkes WD, Witkowski L, Stewart DR 2023 Human mutation 2023

Extrarenal Anaplastic Wilms Tumor: A Case Report with Genomic Analysis and Tumor Models

Willis KR, Sathe AA, Xing C, Koduru P, Artunduaga M, Butler EB, Park JY, Kurmasheva RT, Houghton PJ, Chen KS, Rakheja D 2022 May Journal of Pediatric Hematology/Oncology 44 147-154

Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial

Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D 2022 Feb Pediatric Blood and Cancer 69

Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis

Medvedev KE, Savelyeva AV, Chen KS, Bagrodia A, Jia L, Grishin NV 2022 Jan Cancer Informatics 21

WT-CLS1 is a rhabdoid tumor cell line and can be inhibited by miR-16

Stroup EK, Yeu Y, Budhipramono A, Hwang TH, Rakheja D, Erdreich-Epstein A, Laetsch TW, Amatruda JF, Chen KS 2019 Jun Cancer Reports 2

Mutations in microRNA processing genes in wilms tumors derepress the IGF2 regulator PLAG1

Chen K, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF 2018 Aug Genes and Development 32 996-1007

EGF receptor and mTORC1 are novel therapeutic targets in nonseminomatous germ cell tumors

Chen K, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LH, Laetsch TW, Rakheja D, Amatruda JF 2018 May Molecular Cancer Therapeutics 17 1079-1089

Distinct DICER1 hotspot mutations identify bilateral tumors as separate eventss

Chen KS, Stuart SH, Stroup EK, Shukla AS, Wang J, Rajaram V, Vujanic GM, Slone T, Rakheja D, Amatruda JF 2018 JCO Precision Oncology 1-9

Erratum: Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF 2017 Nature communications 8 16177

p53 genes function to restrain mobile elements

Wylie A, Jones AE, D’Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen K, Hammer RE, Comerford SA, Amatruda JF, Abrams JM 2016 Jan Genes and Development 30 64-77

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Rakheja D, Chen K, Liu Y, Shukla AA, Schmid V, Chang T, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF 2014 Sep Nature communications 2

Invited reply to Amikacin ototoxicity in children with cancer: The problem is the administration schedule

Chen K, Bach A, Shoup A, Winick N 2014 Feb Pediatric Blood and Cancer 61 191

Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides

Chen KS, Bach A, Shoup A, Winick NJ 2013 Nov Pediatric Blood and Cancer 60 1772-1777

DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors

Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen K, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN 2013 Jun BMC Cancer 13

A Big Catch for Germ Cell Tumour Research

Chen KS, Amatruda JF 2013 Apr PLoS genetics 9

Hemolytic non-uremic syndrome

Chen KS, Neunert CE, Crary SE, Buchanan GR 2012 Jul Pediatric Blood and Cancer 59 167-169

A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse

Singleton K, Parvaze N, Dama KR, Chen KS, Jennings P, Purtic B, Sjaastad MD, Gilpin C, Davis MM, Wülfing C 2006 Oct Journal of Immunology 177 4402-4413

Human natural killer cells: A unique innate immunoregulatory role for the CD56bright subset

Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA 2001 May Blood 97 3146-3151