Childhood Kidney Cancer
Wilms tumor is the most common pediatric kidney cancer. Many are driven by mutations in transcription factors, chromatin remodeling factors, or microRNA processing genes. We are studying how these mutations affect gene expression and drive tumor formation. We are performing these studies both in vitro, with cell-line models, and in vivo, generating genetically-engineered mouse models of Wilms tumor mutations. In addition, we are continuing to sequence Wilms tumors to fully describe the landscape of gene dysregulation mechanisms in Wilms tumors.