The Aging Brain
Stress Response Signaling
Traumatic Brain Injury
Research in the Douglas Lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease. We can harness latent stress response pathways and apply their protective properties to a multitude of disease models.
Surveillance pathway tells cells when they run low on lipids
Date: May 18, 2022
Source: UT Southwestern Medical Center
Summary: Researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.
We seek to understand how stress response pathways protect against neurodegenerative disorders.
We utilize the nematode C. elegans to screen for novel factors which mediate protection against blunt trauma.
Our studies examine how imbalances in lipid homeostasis can deleteriously impact health and metabolism.
Our studies examine how the aging process influences traumatic brain injury and neurodegeneration.
Dr. Douglas is a faculty member of the Hamon Center for Regenerative Science and Medicine (CRSM) in the Department of Molecular Biology and an integral part of the Genetics, Development and Disease (GDD), and Neuroscience Graduate Programs at UT Southwestern.
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