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A framework for intestinal barrier dysfunction in aging
Lexus Tatge, Rene Solano Fonseca & Peter M. Douglas
Date Published: 9/18/2023
Journal: Nature Aging
Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization.
Watterson A, Arneaud SLB, Wajahat N, Wall JM, Tatge L, Beheshti ST, Mihelakis M, Cheatwood NY, McClendon J, Ghorashi A, Dehghan I, Corley CD, McDonald JG, Douglas PM.
Date Published: 10/18/2022
Journal: Cell Reports
Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity.
Arneaud SLB, McClendon J, Tatge L, Watterson A, Zuurbier KR, Madhu B, Gumienny TL, Douglas PM,
Date Published: 8/17/2022
Journal: Aging Cell
Intracellular lipid surveillance by small G protein geranylgeranylation.
Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald & Peter M. Douglas
Date Published: 5/18/2022
Journal: Nature
Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
Rene Solano Fonseca, Patrick Metang, Nathan Egge, Yingjian Liu, Kielen R Zuurbier, Karthigayini Sivaprakasam, Shawn Shirazi, Ashleigh Chuah, Sonja LB Arneaud, Genevieve Konopka, Dong Qian, Peter M Douglas
Date Published: 9/2/2021
Journal: eLife
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
Nathan Egge, Sonja L. B. Arneaud, Rene Solano Fonseca, Kielen R. Zuurbier, Jacob McClendon & Peter M. Douglas
Date Published: 3/5/2021
Journal: Nature Communications
Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
Nathan Egge, Sonja L B Arneaud, Pauline Wales, Melina Mihelakis, Jacob McClendon, Rene Solano Fonseca, Charles Savelle, Ian Gonzalez, Atossa Ghorashi, Sivaramakrishna Yadavalli, William J Lehman, Hamid Mirzaei, Peter M Douglas
Date Published: 12/2/2019
Journal: Developmental Cell
- Quantitative pupillometry in patients with traumatic brain injury and loss of consciousness: A prospective pilot study. Traylor JI, El Ahmadieh TY, Bedros NM, Al Adli N, Stutzman SE, Venkatachalam AM, Pernik MN, Collum CM, Douglas PM, Aiyagari V, Bagley CA, Olson DM, Aoun SG, 2021 Sep J Clin Neurosci 91 88-92
- Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Ramadurgum P, Woodard DR, Daniel S, Peng H, Mallipeddi PL, Niederstrasser H, Mihelakis M, Chau VQ, Douglas PM, Posner BA, Hulleman JD, 2020 Mar Cell Chem Biol
- The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. Das R, Melo JA, Thondamal M, Morton EA, Cornwell AB, Crick B, Kim JH, Swartz EW, Lamitina T, Douglas PM, Samuelson AV 2017 Oct PLoS Genet. 10 13 e1007038
- Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Olswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA 2017 Dec Nat Commun 1 8 2270
- The disposable soma theory of aging in reverse. Douglas PM, Dillin A 2014 Jan Cell Res. 1 24 7-8
- RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A 2012 Sep Nature 7415 489 263-8
- Protein homeostasis and aging in neurodegeneration. Douglas PM, Dillin A 2010 Sep J. Cell Biol. 5 190 719-29
- Interplay between protein homeostasis networks in protein aggregation and proteotoxicity Douglas PM, Cyr DM 2010 Mar Biopolymers 3 93 229-36
- Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones. Summers DW, Douglas PM, Ramos CH, Cyr DM 2009 May Trends Biochem. Sci. 5 34 230-3
- The type I Hsp40 Ydj1 utilizes a farnesyl moiety and zinc finger-like region to suppress prion toxicity. Summers DW, Douglas PM, Ren HY, Cyr DM 2009 Feb J. Biol. Chem. 6 284 3628-39
- Prion propagation by Hsp40 molecular chaperones. Summers DW, Douglas PM, Cyr DM 2009 Apr-Jun Prion 2 3 59-64
- Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways. Douglas PM, Summers DW, Cyr DM 2009 Apr-Jun Prion 2 3 51-8