Featured Publications
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW, Science 2021 02 371 6529
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW, Neuron 2019 Apr 102 2 339-357.e7
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis
Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS J. Clin. Invest. 2016 Mar 126 3 1067-78
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment
Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Huang TY, Xu H, J. Clin. Invest. 2019 May 130
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1
Yu H, Cleveland DW Cell 2018 Sep 174 6 1339-1341
Intravital and Kidney Slice Imaging of Podocyte Membrane Dynamics
Brähler S, Yu H, Suleiman H, Krishnan GM, Saunders BT, Kopp JB, Miner JH, Zinselmeyer BH, Shaw AS J. Am. Soc. Nephrol. 2016 Apr
Rac1 activation in podocytes induces rapid foot process effacement and proteinuria
Yu H, Suleiman H, Kim AH, Miner JH, Dani A, Shaw AS, Akilesh S Mol. Cell. Biol. 2013 Dec 33 23 4755-64
Allosteric activation of functionally asymmetric RAF kinase dimers
Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS, Cell 2013 Aug 154 5 1036-1046
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis
Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Gbadegesin R, Antignac C, Pollak M, Kopp JB, Winn MP, Shaw AS, J Clin Invest 2011 Oct 121 10 4127-37
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF, and BRAF
Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS, Proc Natl Acad Sci U S A 2011 Apr 108 15 6067-72
Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor
Liu M, Yu H, Huo L, Liu J, Li M, Zhou J, Biochem Pharmacol 2008 Jul 76 2 169-78