We use cutting-edge approaches in cell biology, molecular biology, and genetics to study neurodegenerative disorders such as frontotemporal dementia (FTD), Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS), and Alzheimer’s disease.
Molecular mechanisms of anisosome formation in cells
TDP-43 aggregation and neuronal RNA bodies
New therapies for neurodegeneration
Many age-related neurodegenerative diseases are associated with intracellular protein aggregates:
- Tau in Alzheimer's disease and frontotemporal dementia
- TDP-43 in frontotemporal dementia and amytrophic lateral sclerosis
- Alpha-synuclein in Parkinson's disease.
We have developed a molecular glue that degrades aggregated proteins. We plan to further test whether molecular glues are effective against tau aggregates in the brain and to apply this approach against other types of protein aggregates.