Publications

Featured Publications

Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation.

Noh J, Isogai T, Chi J, Bhatt K, Danuser G, 2022 Jun Cell Syst 6 13 471-487.e8

Mechanical regulation of glycolysis via cytoskeleton architecture.

Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G, 2020 02 Nature 7796 578 621-626

Discovery of functional interactions among actin regulators by analysis of image fluctuations in an unperturbed motile cell system.

Isogai T, Danuser G, 2018 05 Philos. Trans. R. Soc. Lond., B, Biol. Sci. 1747 373

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.

Isogai T, van der Kammen R, Leyton-Puig D, Kedziora KM, Jalink K, Innocenti M, 2015 Oct J. Cell. Sci. 20 128 3796-810

Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes.

Jiang X, Isogai T, Chi J, Danuser G, 2022 Dec PLoS Comput Biol 12 18 e1009667

Particle retracking algorithm capable of quantifying large, local matrix deformation for traction force microscopy.

Haarman SE, Kim SY, Isogai T, Dean KM, Han SJ, 2022 PLoS One 6 17 e0268614

Actin-Membrane Release Initiates Cell Protrusions.

Welf ES, Miles CE, Huh J, Sapoznik E, Chi J, Driscoll MK, Isogai T, Noh J, Weems AD, Pohlkamp T, Dean K, Fiolka R, Mogilner A, Danuser G, 2020 12 Dev Cell 6 55 723-736.e8

Robust and automated detection of subcellular morphological motifs in 3D microscopy images.

Driscoll MK, Welf ES, Jamieson AR, Dean KM, Isogai T, Fiolka R, Danuser G, 2019 Oct Nat. Methods 10 16 1037-1044

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells.

Mohan AS, Dean KM, Isogai T, Kasitinon SY, Murali VS, Roudot P, Groisman A, Reed DK, Welf ES, Han SJ, Noh J, Danuser G, 2019 05 Dev. Cell 3 49 444-460.e9

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

Argenzio E, Klarenbeek J, Kedziora KM, Nahidiazar L, Isogai T, Perrakis A, Jalink K, Moolenaar WH, Innocenti M, 2018 12 J. Biol. Chem. 50 293 19161-19176

Cell forces meet cell metabolism.

Isogai T, Park JS, Danuser G, 2017 May Nat. Cell Biol. 6 19 591-593

Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors.

Leyton-Puig D, Isogai T, Argenzio E, van den Broek B, Klarenbeek J, Janssen H, Jalink K, Innocenti M, 2017 07 Nat Commun 8 16068

PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteins.

Leyton-Puig D, Kedziora KM, Isogai T, van den Broek B, Jalink K, Innocenti M, 2016 Jul Biol Open 7 5 1001-9

New nuclear and perinuclear functions of formins.

Isogai T, Innocenti M, 2016 12 Biochem. Soc. Trans. 6 44 1701-1708

Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome.

Isogai T, van der Kammen R, Bleijerveld OB, Goerdayal SS, Argenzio E, Altelaar AF, Innocenti M, 2016 12 J. Proteome Res. 12 15 4624-4637

Invadosomes - shaping actin networks to follow mechanical cues.

Kedziora KM, Isogai T, Jalink K, Innocenti M, 2016 06 Front Biosci (Landmark Ed) 21 1092-117

SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton.

Isogai T, van der Kammen R, Innocenti M, 2015 Apr Sci Rep 5 9802

Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2).

Isogai T, van der Kammen R, Goerdayal SS, Heck AJ, Altelaar AF, Innocenti M, 2015 Apr Mol. Cell Proteomics 4 14 1064-78

Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif.

Te Velthuis AJ, Isogai T, Gerrits L, Bagowski CP, 2007 Feb PLoS ONE 2 2 e189