Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain
Wu W, Kumar P, Brautigam CA, Tso S-C, Kober DL* and Gilles-Gonzalez MA*.
Nature Communications. (2024). *Co-corresponding authors
SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain
Hendrix S, Dartigue V, Hall H, Bawaria S, Kingma J, Bajaj B, Zelcer N*, and Kober DL*. Nature Communications. (2024) *Co-corresponding authors
Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis
Xu S, Donnelly D, Kober DL, Mak M, Radhakrishnan A
J. Lipid Res. In Press (2024). PMID: 39306038
SPRING is a dedicated licensing factor for SREBP-specific activation by S1P.
Hendrix S, Tan JME, Ndoj K, Kingma J, Valiloo M, Zijlstra LF, Ottenhoff R, Seidah NG, Loregger A, Kober DL, and Zelcer N.
Molecular and Cellular Biology. (2024) PMID: 38747374
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo
Kober DL*, Van Dyke MCC, Eitson JL, Boys IN, McDougal MB, Rosenbaum DM*, and Schoggins JW*
mBio (2024). PMID: 38771062.
*Co-corresponding authors
Scap Structures Highlight Key Role for Rotation of Intertwined Luminal Loops in Cholesterol Sensing.
Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai X-C, and Rosenbaum DM. Cell. (2021) PMID: 34139175.
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Kober DL*, Xu S*, Li S, Bajaj B, Liang G, Rosenbaum DM, and Radhakrishnan A. Proceedings of the National Academy of Sciences. (2020) PMID: 33106423.
*Contributed equally.
Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42.
Kober DL, Stuchell-Brereton SD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, and Brett TJ. Alzhiemer’s & Dementia. (2021) PMID: 33090700.
YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
Ohlemacher SI, Xu Y, Kober DL, Malik M, Nix JC, Brett TJ, Henderson JP. J Biol Chem. (2018) PMID: 30355735.
TREM2-ligand interactions in health and disease.
Kober DL and Brett TJ. Journal of Molecular Biology. (2017) PMID: 28432014.
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. eLife (2016) PMID: 27995897.