SPRING is a dedicated licensing factor for SREBP-specific activation by S1P.
Hendrix S, Tan JME, Ndoj K, Kingma J, Valiloo M, Zijlstra LF, Ottenhoff R, Seidah NG, Loregger A, Kober DL, and Zelcer N.
Molecular and Cellular Biology. (2024) in press.
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo
Daniel L. Kober*, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys, Matthew B. McDougal, Daniel M. Rosenbaum*, and John W. Schoggins*
In press at mBio
*Co-corresponding authors
Scap Structures Highlight Key Role for Rotation of Intertwined Luminal Loops in Cholesterol Sensing.
Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai X-C, and Rosenbaum DM. Cell. (2021) PMID: 34139175.
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Kober DL*, Xu S*, Li S, Bajaj B, Liang G, Rosenbaum DM, and Radhakrishnan A. Proceedings of the National Academy of Sciences. (2020) PMID: 33106423.
*Contributed equally.
Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42.
Kober DL, Stuchell-Brereton SD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, and Brett TJ. Alzhiemer’s & Dementia. (2021) PMID: 33090700.
YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
Ohlemacher SI, Xu Y, Kober DL, Malik M, Nix JC, Brett TJ, Henderson JP. J Biol Chem. (2018) PMID: 30355735.
TREM2-ligand interactions in health and disease.
Kober DL and Brett TJ. Journal of Molecular Biology. (2017) PMID: 28432014.
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. eLife (2016) PMID: 27995897.