Helmut Krämer, Ph.D.

Publications

Featured Publications

A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress.

Nandi N, Zaidi Z, Tracy C, Krämer H, 2022 Jan Elife 11

Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.

Tyra LK, Nandi N, Tracy C, Krämer H, 2020 Feb Dev. Cell

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration.

Moehlman AT, Casey AK, Servage K, Orth K, Krämer H 2018 Jul Elife 7

Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437.

Nandi N, Tyra LK, Stenesen D, Krämer H 2017 Dec Elife 6

ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.

Akbar MA, Mandraju R, Tracy C, Hu W, Pasare C, Krämer H 2016 Aug Immunity

The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling.

Stenesen D, Moehlman AT, Krämer H 2015 Dec Elife 4

Autophagy Keeps the Balance in Tissue Homeostasis.

Buszczak M, Krämer H, 2019 May Dev. Cell 4 49 499-500

Drosophila p53 directs non-apoptotic programs in postmitotic tissue.

Kurtz P, Jones AE, Tiwari B, Link N, Wylie A, Tracy C, Krämer H, Abrams JM 2019 Mar Mol. Biol. Cell mbcE18120791

The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system.

Stenesen D, Moehlman AT, Schellinger JN, Rodan AR, Krämer H 2019 Feb Sci Rep 1 9 2475

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule.

Sun Q, Wu Y, Jonusaite S, Pleinis JM, Humphreys JM, He H, Schellinger JN, Akella R, Stenesen D, Krämer H, Goldsmith EJ, Rodan AR 2018 Mar J. Am. Soc. Nephrol.

Fic-mediated deAMPylation is not dependent on homo-dimerization and rescues toxic AMPylation in flies.

Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K 2017 Oct J. Biol. Chem.

Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.

Nandi N, Tyra LK, Stenesen D, Krämer H 2014 Oct J. Cell Biol. 2 207 253-68

Unfolded protein response-regulated dFic reversibly AMPylates BiP during endoplasmic reticulum homeostasis.

Ham H, Woolery AR, Tracy C, Stenesen D, Krämer H, Orth K 2014 Nov J. Biol. Chem.

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila.

Takáts S, Pircs K, Nagy P, Varga A, Kárpáti M, Hegedus K, Kramer H, Kovács AL, Sass M, Juhász G 2014 Feb Mol. Biol. Cell

Drosophila melanogaster Cellular Repressor of E1A-stimulated Genes is a lysosomal protein essential for fly development.

Kowalewski-Nimmerfall E, Schähs P, Maresch D, Rendic D, Krämer H, Mach L 2014 Aug Biochim. Biophys. Acta

Route to destruction: Autophagosomes SNARE lysosomes.

Krämer H 2013 May J. Cell Biol. 4 201 495-7

Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.

Maldonado-Báez L, Cole NB, Krämer H, Donaldson JG 2013 Apr J. Cell Biol. 2 201 233-47

Drosophila mauve Mutants Reveal a Role of LYST Homologs Late in the Maturation of Phagosomes and Autophagosomes.

Rahman M, Haberman A, Tracy C, Ray S, Krämer H 2012 Dec Traffic 12 13 1680-92

The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet a-granule biogenesis.

Urban D, Li L, Christensen H, Pluthero FG, Chen SZ, Puhacz M, Garg PM, Lanka KK, Cummings JJ, Kramer H, Wasmuth JD, Parkinson J, Kahr WH 2012 Dec Blood 25 120 5032-40

Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila.

Burgess J, Del Bel LM, Ma CI, Barylko B, Polevoy G, Rollins J, Albanesi JP, Krämer H, Brill JA 2012 Aug Development 16 139 3040-50

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections.

Rahman M, Ham H, Liu X, Sugiura Y, Orth K, Krämer H 2012 Apr

AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila.

Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis PA, Boulianne GL, Chang HC, Le Borgne R, Krämer H, Brill JA 2011 Jun 12 22 2094-105

The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila.

Akbar MA, Tracy C, Kahr WH, Krämer H 2011 Feb J. Cell Biol. 3 192 383-90

Hook2 is involved in the morphogenesis of the primary cilium.

Baron Gaillard CL, Pallesi-Pocachard E, Massey-Harroche D, Richard F, Arsanto JP, Chauvin JP, Lecine P, Krämer H, Borg JP, Le Bivic A 2011 Dec Mol. Biol. Cell 23 22 4549-62

Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.

Haberman AS, Akbar MA, Ray S, Krämer H 2010 Jul Development 13 137 2157-66

The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.

Akbar MA, Ray S, Krämer H 2009 Mar Mol. Biol. Cell 6 20 1705-14

Dynamin-independent synaptic vesicle retrieval?

Krämer H, Kavalali ET 2008 Jan Nat. Neurosci. 1 11 6-8

Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.

Szebenyi G, Hall B, Yu R, Hashim AI, Krämer H 2007 Jan Traffic 1 8 32-46

Hook2 contributes to aggresome formation.

Szebenyi G, Wigley WC, Hall B, Didier A, Yu M, Thomas P, Krämer H 2007 BMC Cell Biol. 8 19

A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila.

Sevrioukov EA, Moghrabi N, Kuhn M, Krämer H 2005 May Mol. Biol. Cell 5 16 2301-12

Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.

Pulipparacharuvil S, Akbar MA, Ray S, Sevrioukov EA, Haberman AS, Rohrer J, Krämer H 2005 Aug J. Cell. Sci. Pt 16 118 3663-73

The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.

Walenta JH, Didier AJ, Liu X, Krämer H 2001 Mar J. Cell Biol. 5 152 923-34

Neuralized: regulating notch by putting away delta.

Krämer H 2001 Dec Dev. Cell 6 1 725-6

Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling.

Narayanan R, Krämer H, Ramaswami M 2000 Nov J. Neurobiol. 2 45 105-19

A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

Sevrioukov EA, He JP, Moghrabi N, Sunio A, Krämer H 1999 Oct Mol. Cell 4 4 479-86

Genetic dissection of endocytic trafficking in Drosophila using a horseradish peroxidase-bride of sevenless chimera: hook is required for normal maturation of multivesicular endosomes.

Sunio A, Metcalf AB, Krämer H 1999 Apr Mol. Biol. Cell 4 10 847-59

Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies.

Krämer H, Phistry M 1996 Jun J. Cell Biol. 6 133 1205-15

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor.

Hart AC, Krämer H, Zipursky SL 1993 Feb Nature 6414 361 732-6

The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand.

Cagan RL, Krämer H, Hart AC, Zipursky SL 1992 May Cell 3 69 393-9

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.

Krämer H, Cagan RL, Zipursky SL 1991 Jul Nature 6332 352 207-12