People

Associate Professor
Director of the TRUST Program
Department of Radiology, UT Southwestern
D1.204, 214-648-5093​
Email

Dr. Jacques Lux is a chemist with deep expertise in materials science and formulation for drug delivery and medical imaging, including MRI, PET, optical, and ultrasound imaging. He earned his PhD in chemistry from the University of Strasbourg in France in 2009 under the mentorship of 2016 Nobel Laureate Jean-Pierre Sauvage, PhD. He further advanced his training through postdoctoral fellowships at The Scripps Research Institute and UC San Diego, focusing on supramolecular chemistry and nanomedicine. In 2015, Dr. Lux joined the Department of Radiology at UT Southwestern as an assistant professor and a founding member of the Translational Research in Ultrasound Theranostics (TRUST) program. In 2025, Dr. Lux became the director of the TRUST program.

Dr. Lux’s research focuses on developing innovative ultrasound-guided drug delivery platforms. He has created advanced microbubbles that significantly improve the loading and delivery of genetic material and small molecule drugs. MUSIC (Microbubble-assisted UltraSound-guided Immunotherapy of Cancer), one of his platforms, has been shown to activate immune responses and drive strong anti-tumor effects in preclinical breast cancer models, and also to enhance the efficacy of immune checkpoint blockade therapy in murine melanoma.

Building on this success, Dr. Lux is expanding this platform to enable image-guided, targeted delivery of treatments to both immune and tumor cells with exceptional precision. His work holds great promise for advancing cancer therapies that stimulate the immune system or silence cancer-driving pathways.