Publications

Featured Publications

AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer.

Marquez-Palencia M, Reza Herrera L, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S, 2024 Jan Cancer Res

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases.

Parida PK, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, Liu XZ, Vu HS, Zacharias LG, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, McDonald JG, Lemoff A, Peng Y, Lewis C, Vale G, Halberg N, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S, 2023 Jun Nat Cancer 6 4 893-907

Cell Competition Shapes Metastatic Latency and Relapse.

Kim K, Huang H, Parida PK, He L, Marquez-Palencia M, Reese TC, Kapur P, Brugarolas J, Brekken RA, Malladi S, 2022 Sep Cancer Discov

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness.

Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S, 2022 Jan Cell Metab 1 34 90-105.e7

Determinants of renal cell carcinoma invasion and metastatic competence.

Kim K, Zhou Q, Christie A, Stevens C, Ma Y, Onabolu O, Chintalapati S, Mckenzie T, Tcheuyap VT, Woolford L, Zhang H, Singla N, Parida PK, Marquez-Palencia M, Pedrosa I, Margulis V, Sagalowsky A, Xie Z, Wang T, Durinck S, Modrusan Z, Seshagiri S, Kapur P, Brugarolas J, Malladi S, 2021 10 Nat Commun 1 12 5760

Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.

Nair VR, Malladi S 2019 Methods Mol. Biol. 1884 141-150

Metastatic Latency, a Veiled Threat.

Kim K, Marquez-Palencia M, Malladi S, 2019 Front Immunol 10 1836

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J 2018 Aug Nat. Cell Biol. 8 20 966-978

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J 2016 Mar Cell 1 165 45-60

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagué J 2013 Aug Cell 5 154 1060-73

A CXCL1 paracrine network links cancer chemoresistance and metastasis.

Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J 2012 Jul Cell 1 150 165-78

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.

Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB 2009 Jul EMBO J. 13 28 1916-25

Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2+ breast cancer brain metastasis.

Parida PK, Marquez-Palencia M, Kaushik AK, Kim K, Nair V, Sudderth J, Vu H, Zacharias L, DeBerardinis R, Malladi S, 2022 Jun STAR Protoc 2 3 101345

Targeting ESR1 mutation-Induced transcriptional addiction in breast cancer with BET inhibition.

Udden SN, Wang Q, Kumar S, Malladi VS, Wu SY, Wei S, Posner BA, Geboers S, Williams NS, Liu YL, Sharma JK, Mani RS, Malladi S, Parra K, Hofstad M, Raj GV, Larios JM, Jagsi R, Wicha MS, Park BH, Gupta GP, Chinnaiyan AM, Chiang CM, Alluri PG, 2022 Jul JCI Insight

Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers.

Kim DS, Camacho CV, Setlem R, Kim K, Malladi S, Hou TY, Nandu T, Gadad SS, Kraus WL, 2022 Aug Mol Cancer Res

Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group.

Kim K, Narasimhan M, Mahimainathan L, Zhang R, Araj E, Kim E, Tharpe W, Greenberg BM, Greenberg DE, Li QZ, Cheng CA, Sarode R, Malladi S, Muthukumar A, 2022 Front Immunol 13 1020165

WNK1 Enhances Migration and Invasion in Breast Cancer Models.

Jaykumar AB, Jung JU, Parida PK, Dang TT, Wichaidit C, Kannangara AR, Earnest S, Goldsmith EJ, Pearson GW, Malladi S, Cobb MH, 2021 Jul Mol Cancer Ther

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities.

Wu CC, Lee S, Malladi S, Chen MD, Mastrandrea NJ, Zhang Z, Bratton SB 2016 Nov Nat Commun 7 13565

Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2.

Malladi S, Parsa KV, Bhupathi D, Rodríguez-González MA, Conde JA, Anumula P, Romo HE, Claunch CJ, Ballestero RP, González-García M 2011 May Mol. Cell. Biochem. 1-2 351 217-32

The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS 2011 Jul Toxicol. Sci. 1 122 64-72

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.

Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB 2009 May J. Biol. Chem. 19 284 12772-82

Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.

Fisher AA, Labenski MT, Malladi S, Gokhale V, Bowen ME, Milleron RS, Bratton SB, Monks TJ, Lau SS 2007 Oct Biochemistry 39 46 11090-100

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.

Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB 2007 Jul EMBO J. 13 26 3144-56

BMRP is a Bcl-2 binding protein that induces apoptosis.

Chintharlapalli SR, Jasti M, Malladi S, Parsa KV, Ballestero RP, González-García M 2005 Feb J. Cell. Biochem. 3 94 611-26