DEPARTMENT OF PEDIATRICS RESEARCH

Mitra Lab

Role of Post-Translational Modifications in Glycogen Metabolism and Associated Diseases

We research the involvement of post-translational modifications (such as ubiquitination, glycosylation) in glycogen biology and its role in glycogen metabolism related neurological and neuromuscular diseases. We also aim to develop appropriate therapies against these diseases using cutting-edge technologies such as gene therapy.

Meet the Principal Investigator (PI)

Learn more about Sharmistha Mitra, Ph.D., and her team.

Meet the PI
Dr. Sharmistha Mitra Photo
Polyglucosans (insoluble glycogen) in the brain of human patient (in red) Polyglucosans (insoluble glycogen) in the brain of human patient (in red)
Huge boulder like polyglucosan (insoluble glycogen) inclusions in the muscle Huge boulder like polyglucosan (insoluble glycogen) inclusions in the muscle
Polyglucosans (insoluble glycogen) in the muscle of a mouse model Polyglucosans (insoluble glycogen) in the muscle of a mouse model
Autophagic inclusions in the muscle of a mouse model as indicated by the light brown spots Autophagic inclusions in the muscle of a mouse model as indicated by the light brown spots
Myo-macrophagy (macrophage invasion of muscle) as indicated by brown staining Myo-macrophagy (macrophage invasion of muscle) as indicated by brown staining
A ligase-trap strategy to identify substrates of LUBAC components A ligase-trap strategy to identify substrates of LUBAC components