Orson W. Moe, M.D.

Selected Publications

Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernandez AF, Zou Z, Yan S, Levine B, Moe OW, Hu MC. The tripartite interaction of phosphate, autophagy, and alphaKlotho in health maintenance. Faseb J 2020;34:3129-50.

Neyra JA, Moe OW, Pastor J, Gianella F, Sidhu SS, Sarnak MJ, Ix JH, Drew DA. Performance of soluble Klotho assays in clinical samples of kidney disease. Clin Kidney J 2020;13:235-44.

Li P, Shi M, Maique J, Shaffer J, Yan S, Moe OW, Hu MC. Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho. Am J Physiol Renal Physiol 2020;318:F772-f92.

Hu MC, Scanni R, Ye J, Zhang J, Shi M, Maique J, Flores B, Moe OW, Krapf R. Dietary vitamin D interacts with high phosphate-induced cardiac remodeling in rats with normal renal function. Nephrol Dial Transplant 2020;35:411-21.

Dhayat NA, Pruijm M, Ponte B, Ackermann D, Leichtle AB, Devuyst O, Ehret G, Guessous I, Pechere-Bertschi A, Pastor J, Martin PY, Burnier M, Fiedler GM, Vogt B, Moe OW, Bochud M, Fuster DG. Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble alpha-Klotho Levels in Adults of European Descent. J Clin Endocrinol Metab 2020;105:dgz232.

Zhang J, Cao K, Pastor JV, Li L, Moe OW, Hsia CCW. Alpha-Klotho, a critical protein for lung health, is not expressed in normal lung. FASEB Bioadv 2019;1:675-87.

Suassuna PGA, de Paula RB, Sanders-Pinheiro H, Moe OW, Hu MC. Fibroblast growth factor 21 in chronic kidney disease. J Nephrol 2019;32:365-77.

Quinones H, Hamdi T, Sakhaee K, Pasch A, Moe OW, Pak CYC. Control of metabolic predisposition to cardiovascular complications of chronic kidney disease by effervescent calcium magnesium citrate: a feasibility study. J Nephrol 2019;32:93-100.

Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W. High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice. Circulation 2019;139:1422-34.

Pastor J, Moe OW. Treating Systemic Klotho Deficiency. Am J Nephrol 2019;49:410-2.

Neyra JA, Li X, Mescia F, Ortiz-Soriano V, Adams-Huet B, Pastor J, Hu MC, Toto RD, Moe OW. Urine Klotho Is Lower in Critically Ill Patients With Versus Without Acute Kidney Injury and Associates With Major Adverse Kidney Events. Crit Care Explor 2019;1:e0016.

Neyra JA, Hu MC, Minhajuddin A, Nelson GE, Ahsan SA, Toto RD, Jessen ME, Moe OW, Fox AA. Kidney Tubular Damage and Functional Biomarkers in Acute Kidney Injury Following Cardiac Surgery. Kidney Int Rep 2019;4:1131-42.

Maalouf NM, Poindexter JR, Adams-Huet B, Moe OW, Sakhaee K. Increased production and reduced urinary buffering of acid in uric acid stone formers is ameliorated by pioglitazone. Kidney Int 2019;95:1262-8.

Khamaysi A, Anbtawee-Jomaa S, Fremder M, Eini-Rider H, Shimshilashvili L, Aharon S, Aizenshtein E, Shlomi T, Noguchi A, Springer D, Moe OW, Shcheynikov N, Muallem S, Ohana E. Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis. J Am Soc Nephrol 2019;30:381-92.

Hu MC, Shi M, Moe OW. Role of alphaKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters. Pflugers Arch 2019;471:99-108.

Ferre S, Li X, Adams-Huet B, Maalouf NM, Sakhaee K, Toto RD, Moe OW, Neyra JA. Low serum magnesium is associated with faster decline in kidney function: the Dallas Heart Study experience. J Investig Med 2019;67:987-94.

Ferre S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW. Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation. Kidney Int 2019;96:1359-73.

Deisl C, Fine M, Moe OW, Hilgemann DW. Hypertrophy of human embryonic stem cell-derived cardiomyocytes supported by positive feedback between Ca(2+) and diacylglycerol signals. Pflugers Arch 2019;471:1143-57.

Clark AT, Li X, Kulangara R, Adams-Huet B, Huen SC, Madni TD, Imran JB, Phelan HA, Arnoldo BD, Moe OW, Wolf SE, Neyra JA. Acute Kidney Injury After Burn: A Cohort Study From the Parkland Burn Intensive Care Unit. J Burn Care Res 2019;40:72-8.

Bobulescu IA, Park SK, Xu LHR, Blanco F, Poindexter J, Adams-Huet B, Davidson TL, Sakhaee K, Maalouf NM, Moe OW. Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis. Clin J Am Soc Nephrol 2019;14:411-20.

Song P, Zechner C, Hernandez G, Canovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA. The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol. Cell Metab 2018;27:1338-47.e4.

Shi M, McMillan KL, Wu J, Gillings N, Flores B, Moe OW, Hu MC. Cisplatin nephrotoxicity as a model of chronic kidney disease. Lab Invest 2018;98:1105-21.

Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC. Effects of Erythropoietin Receptor Activity on Angiogenesis, Tubular Injury and Fibrosis in Acute Kidney Injury: A "U-Shaped" Relationship. Am J Physiol Renal Physiol 2018;314:F501-F16.

Pathare G, Dhayat NA, Mohebbi N, Wagner CA, Bobulescu IA, Moe OW, Fuster DG. Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular acidosis. Kidney Int 2018;93:871-80.

Neyra JA, Mescia F, Li X, Adams-Huet B, Yessayan L, Yee J, Toto RD, Moe OW. Impact of Acute Kidney Injury and CKD on Adverse Outcomes in Critically Ill Septic Patients. Kidney Int Rep 2018;3:1344-53.

Moe OW, Xu LHR. Hyperuricosuric calcium urolithiasis. J Nephrol 2018;31:189-96.

Moe OW, Bushinsky D, Kuiper JJ. Genetic Hypercalciuria: A Major Risk Factor in Kidney Stones. In: Thakker RV, Whyte MP, Eisman JA, Igarashi T, eds. Genetics of Bone Biology and Skeletal Disease. Second ed. London, United Kingdom: Academic Press; 2018:819-38.

Johnson RJ, Bakris GL, Borghi C, Chonchol MB, Feldman D, Lanaspa MA, Merriman TR, Moe OW, Mount DB, Sanchez Lozada LG, Stahl E, Weiner DE, Chertow GM. Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. Am J Kidney Dis 2018;71:851-65.

Gazdar A, Ravikumar P, Pastor J, Heller M, Ye J, Zhang J, Moe OW, Geiser T, Hsia CCW. Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury. Stem Cells 2018;36:616-25.

Fuster DG, Moe OW. Incomplete Distal Renal Tubular Acidosis and Kidney Stones. Adv Chronic Kidney Dis 2018;25:366-74.

Ferre S, Li X, Adams-Huet B, Maalouf NM, Sakhaee K, Toto RD, Moe OW, Neyra JA. Association of serum magnesium with all-cause mortality in patients with and without chronic kidney disease in the Dallas Heart Study. Nephrol Dial Transplant 2018;33:1389-96.

Fernandez AF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature 2018;558:136-40.

Doizi S, Poindexter JR, Pearle MS, Blanco F, Moe OW, Sakhaee K, Maalouf NM. Impact of Potassium Citrate vs. Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone Formers. J Urol 2018;200:1278-84.

Chen G, Liu Y, Goetz R, Fu L, Jayaraman S, Hu MC, Moe OW, Liang G, Li X, Mohammadi M. alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature 2018;553:461-6.

Xu LHR, Adams-Huet B, Poindexter JR, Maalouf NM, Moe OW, Sakhaee K. Temporal Changes in Kidney Stone Composition and in Risk Factors Predisposing to Stone Formation. J Urol 2017;197:1465-71.

Sakhaee K, Maalouf NM, Poindexter J, Adams-Huet B, Moe OW. Relationship between Urinary Calcium and Bone Mineral Density in Patients with Calcium Nephrolithiasis. J Urol 2017;197:1472-7.

Rutkowski JM, Pastor J, Sun K, Park SK, Bobulescu IA, Chen CT, Moe OW, Scherer PE. Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression. Kidney Int 2017;91:324-37.

Lotan Y, Antonelli J, Jimenez IB, Gharbi H, Herring R, Beaver A, Dennis A, Von Merveldt D, Carter S, Cohen A, Poindexter J, Moe OW, Pearle MS. The kidney stone and increased water intake trial in steel workers: results from a pilot study. Urolithiasis 2017;45:177-83.

Kuro OM, Moe OW. FGF23-alphaKlotho as a paradigm for a kidney-bone network. Bone 2017;100:4-18.

Hu MC, Shi M, Gillings N, Flores B, Takahashi M, Kuro OM, Moe OW. Recombinant alpha-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy. Kidney Int 2017;91:1104-14.

Hu MC, Bobulescu IA, Quinones H, Gisler SM, Moe OW. Dopamine reduces cell surface Na(+)/H(+) exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling. Am J Physiol Renal Physiol 2017;313:F1018-f25.

Hruska KA, Lanske B, Moe OW. Crosstalk between kidney and bone - Bench to bedside. Bone 2017;100:1-3.

Ferre S, Grange JS, Adams-Huet Ms B, Moe OW, Maalouf NM. Effect of urine pH and magnesium on calcium oxalate saturation. Magnes Res 2017;30:107-19.

Dhayat NA, Gradwell MW, Pathare G, Anderegg M, Schneider L, Luethi D, Mattmann C, Moe OW, Vogt B, Fuster DG. Furosemide/Fludrocortisone Test and Clinical Parameters to Diagnose Incomplete Distal Renal Tubular Acidosis in Kidney Stone Formers. Clin J Am Soc Nephrol 2017;12:1507-17.

Zacchia M, Zacchia E, Zona E, Capolongo G, Raiola I, Rinaldi L, Trepiccione F, Ingrosso D, Perna A, Di Iorio V, Simonelli F, Moe OW, Capasso G. Renal phenotype in Bardet-Biedl syndrome: a combined defect of urinary concentration and dilution is associated with defective urinary AQP2 and UMOD excretion. Am J Physiol Renal Physiol 2016;311:F686-f94.

Vongpatanasin W, Peri-Okonny P, Velasco A, Arbique D, Wang Z, Ravikumar P, Adams-Huet B, Moe OW, Pak CY. Effects of Potassium Magnesium Citrate Supplementation on 24-Hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects. Am J Cardiol 2016;118:849-53.

Ravikumar P, Menon JU, Punnakitikashem P, Gyawali D, Togao O, Takahashi M, Zhang J, Ye J, Moe OW, Nguyen KT, Hsia CC. Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine 2016;12:811-21.

Ravikumar P, Li L, Ye J, Shi M, Taniguchi M, Zhang J, Kuro OM, Hu MC, Moe OW, Hsia CC. alphaKlotho deficiency in acute kidney injury contributes to lung damage. J Appl Physiol (1985) 2016;120:723-32.

Mizuno M, Mitchell JH, Crawford S, Huang CL, Maalouf N, Hu MC, Moe OW, Smith SA, Vongpatanasin W. High dietary phosphate intake induces hypertension and augments exercise pressor reflex function in rats. Am J Physiol Regul Integr Comp Physiol 2016;311:R39-48.

Hu MC, Shi M, Zhang J, Addo T, Cho HJ, Barker SL, Ravikumar P, Gillings N, Bian A, Sidhu SS, Kuro-o M, Moe OW. Renal Production, Uptake, and Handling of Circulating alphaKlotho. J Am Soc Nephrol 2016;27:79-90.