Publications

Role for IRAK-4 and p38 in Neutrophil Signaling in Response to Bacterial Lipoproteins from Staphylococcus aureus

Hook JS, Matheis AD, Kavanaugh JS, Horswill AR, Moreland JG 2025 Aug Inflammation 48 1704-1715

Does serial procalcitonin monitoring predict clinical outcomes in children with sepsis? A diagnostic stewardship study

Rubbab B, Davila S, Moreland J, Firmani S, Most Z 2025 Jun Antimicrobial Stewardship and Healthcare Epidemiology 5

Granular Insights: Neutrophil Predominance and Elastase Release in Severe Asthma Exacerbations in a Pediatric Cohort

Henley K, Tresselt E, Hook JS, Patel PA, Gill MA, Moreland JG 2024 Mar Cells 13

Quantifying neutrophil extracellular trap release in a combined infection-inflammation NET-array device

Datla US, Vundurthy B, Hook JS, Menon N, Razmi Bagtash H, Shihabeddin T, Schmidtke DW, Moreland JG, Radic MZ, Jones CN 2024 Jan Lab on a Chip 24 615-628

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

Li Y, Hook JS, Ding Q, Xiao X, Chung SS, Mettlen M, Xu L, Moreland JG, Agathocleous M 2023 Dec Nature communications 14

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Crossley JL, Ostashevskaya-Gohstand S, Comazzetto S, Hook JS, Guo L, Vishlaghi N, Juan C, Xu L, Horswill AR, Hoxhaj G, Moreland JG, Tower RJ, Levi B 2023 Oct JCI Insight 8

Evaluation of an association between RANKL and OPG with bone disease in people with cystic fibrosis

Abid S, Lee MJ, Rodich B, Hook JS, Moreland JG, Towler D, Maalouf NM, Keller A, Ratti G, Jain R 2023 Jan Journal of Cystic Fibrosis 22 140-145

Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 Patients

Kinnare N, Hook JS, Patel PA, Monson NL, Moreland JG 2022 Apr Inflammation 45 800-811

Novel neutrophil phenotypic signature in pediatric patients with type 1 diabetes and diabetic ketoacidosis

Nichols BE, Hook JS, Weng K, Ahn C, Moreland JG 2022 Apr Journal of Leukocyte Biology 111 849-856

Lipoproteins from staphylococcus aureus drive neutrophil extracellular trap formation in a TLR2/1- And PAD-dependent manner

Hook JS, Patel PA, O'Malley A, Xie L, Kavanaugh JS, Horswill AR, Moreland JG 2021 Aug Journal of Immunology 207 :966-973

Mycobacterium tuberculosis lipoarabinomannan activates human neutrophils via a TLR2/1 mechanism distinct from Pam3CSK4

Hook JS, Cao M, Weng K, Kinnare N, Moreland JG 2020 Feb Journal of Immunology 204 671-681

Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice

Potera RM, Cao M, Jordan LF, Hogg RT, Hook JS, Moreland JG 2019 Feb Inflammation 42 185-198

Nox2 regulates platelet activation and net formation in the lung

Hook JS, Cao M, Potera RM, Alsmadi NZ, Schmidtke DW, Moreland JG 2019 Frontiers in immunology 10

Neutrophil Phenotype Correlates with Postoperative Inflammatory Outcomes in Infants Undergoing Cardiopulmonary Bypass

Huber JN, Hilkin BM, Hook JS, Brophy PD, Davenport TL, Davis JE, Colaizy TT, Moreland JG 2017 Dec Pediatric Critical Care Medicine 18 1145-1152

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

Potera RM, Jensen MJ, Hilkin BM, South GK, Hook JS, Gross EA, Moreland JG 2016 Nov Innate Immunity 22 635-646

Craniectomy and Traumatic Brain Injury in Children on Extracorporeal Membrane Oxygenation Support: Case Report and Review of the Literature

Anton-Martin P, Braga B, Megison S, Journeycake J, Moreland J 2016 Oct Pediatric Emergency Care

Interferon Regulatory factor 6 has a protective role in the host response to endotoxic shock

Joly S, Rhea L, Volk P, Moreland JG, Dunnwald M 2016 Apr PloS one 11

Evaluation of hematologic variables in newborn C57/BL6 mice up to day 35

White JR, Gong H, Colaizy TT, Moreland JG, Flaherty H, Mcelroy SJ 2016 Mar Veterinary Clinical Pathology 45 87-95

A common genetic variant in TLR1 enhances human neutrophil priming and impacts length of intensive care stay in pediatric sepsis

Whitmore LC, Hook JS, Philiph AR, Hilkin BM, Bing X, Ahn C, Wong HR, Ferguson PJ, Moreland JG 2016 Feb Journal of Immunology 196 1376-1386

NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome

Whitmore LC, Goss KL, Newell EA, Hilkin BM, Hook JS, Moreland JG 2014 Jul American Journal of Physiology - Lung Cellular and Molecular Physiology 307 L71-L82

The immune system in critical illness and injury

Moreland JG 2014 Jan 421-429

ROS-containing endosomal compartments: Implications for signaling

Paige Davis Volk A, Moreland JG 2014 201-224

NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults

Whitmore LC, Hilkin BM, Goss KL, Wahle EM, Colaizy TT, Boggiatto PM, Varga SM, Miller FJ, Moreland JG 2013 Nov Journal of innate immunity 5 565-580

Transepithelial migration of neutrophils into the lung requires TREM-1

Klesney-Tait J, Keck K, Li X, Gilfillan S, Otero K, Baruah S, Meyerholz DK, Varga SM, Knudson CJ, Moninger TO, Moreland J, Zabner J, Colonna M 2013 Jan Journal of Clinical Investigation 123 138-149

Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species

Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG 2012 Apr Journal of Biological Chemistry 287 12395-12404

Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent

Volk AP, Barber BM, Goss KL, Ruff JG, Heise CK, Hook JS, Moreland JG 2011 Apr Journal of innate immunity 3 298-314

The Accreditation Council for Graduate Medical Education proposed work hour regulations

Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ 2011 Jan Pediatric Critical Care Medicine 12 120-121

Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis

McCaffrey RL, Schwartz JT, Lindemann SR, Moreland JG, Buchan BW, Jones BD, Allen LA 2010 Oct Journal of Leukocyte Biology 88 791-805

Activation of swelling-activated chloride current by tumor necrosis factor-α requires ClC-3-dependent endosomal reactive oxygen production

Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS 2010 Jul Journal of Biological Chemistry 285 22864-22873

Electrophysiology of reactive oxygen production in signaling endosomes

Lamb FS, Moreland JG, Miller FJ 2009 Jun Antioxidants and Redox Signaling 11 1335-1347

Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype

Moreland JG, Hook JS, Bailey G, Ulland T, Nauseef WM 2009 Jun American Journal of Physiology - Lung Cellular and Molecular Physiology 296 L1076-L1084

ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells

Drake JM, Strohbehn G, Bair TB, Moreland JG, Henry MD 2009 Apr Molecular Biology of the Cell 20 2207-2217

ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change

Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG 2008 Dec Journal of Biological Chemistry 283 34315-34326

Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent

Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS 2008 Jan American Journal of Physiology - Cell Physiology 294 C251-C262

Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3

Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS 2007 Nov Journal of Biological Chemistry 282 33958-33967

Pre-Surgical Evaluation of Interrupted Aortic Arch With 3-Dimensional Reconstruction of CT Images

Morriss J, Moreland J, Burkhart H, Kao S 2007 Jul Annals of Thoracic Surgery 84 299

The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels

Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE 2006 Jun Journal of General Physiology 127 659-672

Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration

Moreland JG, Davis AP, Bailey G, Nauseef WM, Lamb FS 2006 May Journal of Biological Chemistry 281 12277-12288

Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent

Moreland JG, Bailey G 2006 May American Journal of Physiology - Lung Cellular and Molecular Physiology 290 L833-L840

Organism-Specific Neutrophil-Endothelial Cell Interactions in Response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus

Moreland JG, Bailey G, Nauseef WM, Weiss JP 2004 Jan Journal of Immunology 172 426-432

CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease

Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA 2002 Oct American journal of respiratory cell and molecular biology 27 474-480

TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease

Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA 2001 Jan American Journal of Physiology - Lung Cellular and Molecular Physiology 280 L173-L180