Our laboratory combines innovative basic science approaches, in vivo models, and clinical studies to investigate the role of the innate immune system in the development and resolution of inflammation. From the investigation of multi-organ dysfunction in whole animal models of systemic inflammation to the elucidation of the mechanisms involved in the trafficking of cellular proteins critical for neutrophil responses, we are committed to gaining a better understanding of the basic functions of the innate immune system with the long term goal of improving outcomes for people with inflammatory conditions.
Some of our current projects include:
- The role of NADPH oxidase 2 (Nox2)-derived reactive oxygen species (ROS) in maintaining cellular quiescence and resolving inflammation
- The role of alveolar and interstitial macrophages in limiting and resolving acute lung injury
- Mechanisms involved in priming of neutrophil ROS and granule mobilization
- Trafficking of pattern recognition receptors in neutrophils and monocytes
- Investigation of pro- and anti-inflammatory signaling mediators
- Neutrophil priming in infants undergoing cardiopulmonary bypass and the effect on post-operative inflammatory outcomes
- Neutrophil activation state in pediatric patients with inflammatory bowel disease and correlation with disease severity
- The role of neutrophil-based inflammation in development of diabetic ketoacidosis in patients with type 1 diabetes