Publications

Featured Publications

The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.

Phillips JE, Pan D, 2023 Jul bioRxiv

Control of stem cell renewal and fate by YAP and TAZ.

Driskill JH, Pan D, 2023 Aug Nat Rev Mol Cell Biol

YAP-VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP.

Cai J, Choi K, Li H, Pulgar Prieto KD, Zheng Y, Pan D, 2022 Nov-Dec 1 Genes Dev 21-24 36 1119-1128

Multiphase coalescence mediates Hippo pathway activation.

Wang L, Choi K, Su T, Li B, Wu X, Zhang R, Driskill JH, Li H, Lei H, Guo P, Chen EH, Zheng Y, Pan D, 2022 Nov Cell 23 185 4376-4393.e18

YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis.

Wu BK, Mei SC, Chen EH, Zheng Y, Pan D, 2022 Jul Nat Genet

YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis.

Li H, Wu BK, Kanchwala M, Cai J, Wang L, Xing C, Zheng Y, Pan D, 2022 Feb Nat Cell Biol

The unfolding of the Hippo signaling pathway.

Pan D, 2022 Apr Dev Biol 487 1-9

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis.

Phillips JE, Santos M, Konchwala M, Xing C, Pan D, 2022 06 Elife 11

WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma.

Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, Dellinger M, Pan D, 2021 Mar Genes Dev

Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.

Deng H, Yang L, Wen P, Lei H, Blount P, Pan D, 2020 Apr J. Cell Biol. 4 219

Nerfin-1 represses transcriptional output of Hippo signaling in cell competition.

Guo P, Lee CH, Lei H, Zheng Y, Pulgar Prieto KD, Pan D, 2019 Mar Elife 8

YAP is essential for Treg mediated suppression of anti-tumor immunity.

Ni X, Tao J, Barbi J, Chen Q, Park BV, Li Z, Zhang N, Lebid A, Ramaswamy A, Wei P, Zheng Y, Zhang X, Wu X, Vignali PDA, Yang C, Li H, Pardoll D, Lu L, Pan D, Pan F 2018 Jun Cancer Discov

A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.

Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, Pan D 2018 Jun Genes Dev. 11-12 32 781-793

Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped-based genetic epistasis.

Yu J, Pan D, 2018 02 Development 4 145

Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex.

Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto KD, Pan D 2017 Dec Cell Rep 12 21 3612-3623

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila.

Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D 2016 Jan Cell 3 164 406-19

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade.

Zheng Y, Wang W, Liu B, Deng H, Uster E, Pan D 2015 Sep Dev. Cell 6 34 642-55

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP.

Chen Q, Zhang N, Xie R, Wang W, Cai J, Choi KS, David KK, Huang B, Yabuta N, Nojima H, Anders RA, Pan D 2015 Jun Genes Dev. 12 29 1285-97

?-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.

Cai J, Maitra A, Anders RA, Taketo MM, Pan D 2015 Jul Genes Dev. 14 29 1493-506

Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.

Ni L, Zheng Y, Hara M, Pan D, Luo X 2015 Jul Genes Dev. 13 29 1416-31

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity.

Deng H, Wang W, Yu J, Zheng Y, Qing Y, Pan D 2015 Elife 4 e06567

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis.

Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D 2014 Mar Genes Dev. 5 28 432-7

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.

Qing Y, Yin F, Wang W, Zheng Y, Guo P, Schozer F, Deng H, Pan D 2014 Elife 3

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D 2013 Sep Cell 6 154 1342-55

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.

Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X 2013 Oct Structure 10 21 1757-68

The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.

Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D 2013 May Dev. Cell 4 25 388-401

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D 2012 Jun Genes Dev. 12 26 1300-5

Premetazoan origin of the hippo signaling pathway.

Sebé-Pedrós A, Zheng Y, Ruiz-Trillo I, Pan D 2012 Jan Cell Rep 1 1 13-20

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program.

Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A, Pan D 2010 Nov Genes Dev. 21 24 2383-8

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.

Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, Wu S, Pan D 2010 Jun Proc. Natl. Acad. Sci. U.S.A. 23 107 10532-7

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J, Giovannini M, Liu P, Anders RA, Pan D 2010 Jul Dev. Cell 1 19 27-38

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.

Yu J, Zheng Y, Dong J, Klusza S, Deng WM, Pan D 2010 Feb Dev. Cell 2 18 288-99

Structural and functional analysis of the YAP-binding domain of human TEAD2.

Tian W, Yu J, Tomchick DR, Pan D, Luo X 2010 Apr Proc. Natl. Acad. Sci. U.S.A. 16 107 7293-8

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

Wu S, Liu Y, Zheng Y, Dong J, Pan D 2008 Mar Dev. Cell 3 14 388-98

Elucidation of a universal size-control mechanism in Drosophila and mammals.

Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D 2007 Sep Cell 6 130 1120-33

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

Huang J, Wu S, Barrera J, Matthews K, Pan D 2005 Aug Cell 3 122 421-34

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.

Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D 2003 Jun Nat. Cell Biol. 6 5 578-81

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

Wu S, Huang J, Dong J, Pan D 2003 Aug Cell 4 114 445-56

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D 2002 Sep Nat. Cell Biol. 9 4 699-704

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.

Gao X, Pan D 2001 Jun Genes Dev. 11 15 1383-92