Key Publications from the Parkland NICU Database

  1. Stumpf K, Sharma P, Brown LS, Brion LP, Mirpuri J. Maternal body mass index and necrotizing enterocolitis: a case-control study. PLOS one 2024 Jan 24;19(1):e0296644. doi: 10.1371/journal.pone.0296644. PMID: 38266000. 
  2. Reis JD, Heyne R, Rosenfeld CR, Caraig M, Brown LS, Burchfield PJ, Lair CS, Petrosyan E, Jabob T, Nelson DB, Brion LP. Follow-up of a randomized trial optimizing neonatal nutrition in preterm very low birthweight infants: growth, serum adipokines, renal function and blood pressure. J Perinatol. 2024 Jan;44(1):78-86. doi: 10.1038/s41372-023-01821-2. Epub 2023 Nov 14. PMID: 37964083. 
  3. Nayak SP, Sanchez-Rosado M, Reis JD, Brown LS, Mangona KL, Sharma P, Nelson DB, Wyckoff MH, Pandya S, Mir IN. Brion LP. Development of a prediction model for surgery or early mortality at the time of initial assessment for necrotizing enterocolitis. Am J Perinatol. 2024 Jan 25. doi: 10.1055/a-2253-8656. Epub ahead of print. PMID: 38272063.  
  4. Sanchez-Rosado M, Reis JD, Jaleel MA, Clipp K, Mangona KL, Brown LS, Nelson DB, Wyckoff MH, Verma D, Kiefaber I, Lair CS, Nayak SP, Burchfield PJ, Thomas A, Brion LP. Impact of Size for Gestational Age on Multivariate Analysis of Factors Associated with Necrotizing Enterocolitis in Preterm Infants: Retrospective Cohort Study. Am J Perinatol. 2023 Sep 28. doi: 10.1055/a-2183-5155. Epub ahead of print. PMID: 37769697. 
  5. Sanchez-Rosado M, Lair CS, Edwards A, Jacob T, Heyne R, Brown LS, Clark C, Nelson DB, Wyckoff MH, Kiefaber I, Verma D, Reis J, Burchfield PJ, Sepulveda P, Brion LP. Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study. J Perinatol. 2023 May;43(5):608-615. doi: 10.1038/s41372-023-01627-2. Epub ahead of print. PMID: 36737571;  PMCID: PMC9897884. 
  6. Reis JD, Hagan T, Heyne R, Tolentino-Plata K, Clarke R, Brown S, Rosenfeld CR, Burchfield PJ, Caraig M, Brion LP. Relationship between ventricular size on latest ultrasonogram and Bayley scores in extremely low gestational age neonates. Am J Perinatol 2023, Mar 18. doi: 10.1055/a-2057-7454. Epub ahead of print. PMID: 36933551. 
  7. Reis JD, Tolentino-Plata K, Caraig M, Heyne R, Rosenfeld CR, Brown LS, Brion LP. Double-blinded randomized controlled trial of optimizing nutrition in preterm very low birth weight infants: Bayley scores at 18-38 months of age. J Perinatol. 2023 Jan;43(1):81-85. doi: 10.1038/s41372-022-01572-6. Epub 2022 Dec 6. PMID: 36473929. 
  8. Mir IN, Sanchez-Rosado M, Reis J, Uddin N, Brown LS, Mangona KL, Nelson D, Wyckoff M, Nayak SP, Brion L. Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants. Pediatr Res. 2023 Dec 8. doi: 10.1038/s41390-023-02942-2. Epub ahead of print. PMID: 38066247.
  9. Chiu M, Mir I, Adhikari E, Heyne R, Ornelas N, Tolentino-Plata K, Thomas A, Burchfield P, Simcik V, Ramon E, Brown LS, Nelson DB, Wyckoff MH, Kakkilaya V. Risk Factors for Admission Hyperthermia and Associated Outcomes in Preterm Infants. J Pediatr. 2023 Nov 21:113842. doi: 10.1016/j.jpeds.2023.113842. Epub ahead of print. PMID: 37995929.
  10. Chan CS, Chiu M, Ariyapadi S, Brown LS, Burchfield P, Simcik V, Garcia K, Mazioniene K, Jaleel MA, Wyckoff MH, Kapadia VS, Kakkilaya V. Evaluation of a respiratory care protocol including less invasive surfactant administration in preterm infants. Pediatr Res. 2023 Dec 14. doi: 10.1038/s41390-023-02963-x. Epub ahead of print. PMID: 38097721.
  11. Weydig HM, Rosenfeld CR, Wyckoff MH, Jaleel MA, Burchfield PJ, Thomas A, Frost MS, Brion LP. Association of antenatal steroids with surfactant administration in moderate preterm infants born to women with diabetes mellitus and/or hypertension. J Perinatol. 2022 Aug;42(8):993-1000. doi: 10.1038/s41372-021-01273-6. Epub 2021 Nov 20. PMID: 34802046; PMCID: PMC8605443.
  12. Stocks E, Jaleel M, Smithhart W, Burchfield P, Thomas A, Clark C, Mangona KLM, Brown LS, Kapadia V, Wyckoff M, Kakkilaya V, Brenan S, Nelson DB, Brion LP. Delivery Room (DR) Continuous Positive Airway Pressure (CPAP)-Associated Pneumothorax in Term and Late-Preterm Neonates. J Perinatology, 2022, DOI 10.1038/s41372-022-01334-4, PMID: 35173286
  13. Abbey NV, Mashruwala V, Weydig HM, Steven Brown L, Ramon EL, Ibrahim J, Mir IN, Wyckoff MH, Kapadia V. Electrocardiogram for heart rate evaluation during preterm resuscitation at birth: a randomized trial. Pediatr Res. 2022 May;91(6):1445-1451. doi: 10.1038/s41390-021-01731-z. Epub 2021 Oct 13. Erratum in: Pediatr Res. 2021 Dec 17;: PMID: 34645954; PMCID: PMC8513736.
  14. Weydig HM, Rosenfeld CR, Jaleel MA, Burchfield PJ, Frost MS, Brion LP. Association of Antenatal Steroids and Neonatal Mortality and Morbidity in Preterm Infants Born to Mothers with Diabetes Mellitus and Gestational Hypertension. J Perinatology 2021, Jul;41(7):1660-1668. doi: 10.1038/s41372-021-01090-x. Online ahead of print. PMID: 34035455.
  15. Sivarajan M, Schneider JH, Johnson KA, Bai S, ElHassan N, Kaiser JR, Nelson DB, Brown SL, Burchfield PJ, Brion LP, Decreasing early hypoglycemia frequency in at-risk newborns after implementing a new hypoglycemia screening algorithm. J Perinatology 2021, Nov 17. doi: 10.1038/s41372-021-01263-8. Online ahead of print. PMID: 34789816 
  16. Reis J, Tolentino-Plata K, Heyne R, Rosenfeld CR, Caraig M, Brion LP. Quality Improvement Project Designed to Reduce Disproportionate Growth in Extremely Low Gestational Age Neonates: Association with Cognitive Neurodevelopmental Outcomes. J Perinatology 2021 Mar 26 : 1–9. doi: 10.1038/s41372-021-01047-0 [Epub ahead of print] PMCID:  PMC7995674. PMID: 33772110 
  17. Mir, I.N., White, S.P., Steven Brown, L. et al. Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case–control study. Pediatr Res 89, 1825–1831 (2021). doi.org/10.1038/s41390-020-01160-4
  18. Kakkilaya VB, Weydig HM, Smithhart WE, Renfro SD, Garcia KM, Brown CM, He H, Wagner SA, Metoyer GC, Brown LS, Kapadia VS, Savani RC, Jaleel MA. Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants. Pediatrics. 2021 Oct;148(4):e2020014191. doi: 10.1542/peds.2020-014191. Epub 2021 Sep 22. PMID: 34552000
  19. Kakkilaya V, Tang A, Wagner S, Ridpath J, Ibrahim J, Brown LS, Rosenfeld CR. Discontinuing Nasal Continuous Positive Airway Pressure in Infants ≤32 Weeks of Gestational Age: A Randomized Control Trial. J Pediatr. 2021 Mar;230:93-99.e3. doi: 10.1016/j.jpeds.2020.10.045. Epub 2020 Oct 28. PMID: 33127365.
  20. Mir IN, Chalak LF, Brown LS, Johnson-Welch S, Heyne R, Rosenfeld CR, Kapadia VS. Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants. Pediatr Res. 2020 Apr;87(5):885-891. doi: 10.1038/s41390-019-0715-y. Epub 2019 Dec 7. PMID: 31812153; PMCID: PMC7223700.
  21. Brion LP, Heyne R, Brown LS, Lair CS, Edwards A, Burchfield PJ, Caraig M. Zinc Deficiency Limiting Head Growth to Discharge in Extremely Low Gestational Age Infants with Insufficient Linear Growth: A cohort Study. J Perinatol 2020;10.1038/s41372-020-00778-w. doi:10.1038/s41372020-00778-w. PMID: 32788617
  22. Brion LP, Rosenfeld CR, Heyne R, Brown LS, Lair CS, Heyne E, Dohoney EL, Burchfield PJ, Caraig M. Association of Age of Initiation and Type and of Complementary Foods with Body Mass Index and Weight-Length at Twelve Months of Age in Preterm Infants. J Perinatol 2020, Mar 9. doi: 10.1038/s41372-020-0637-x. [Epub ahead of print]. PMID: 32152493
  23. Brion LP, Rosenfeld CR, Heyne R, Brown LS, Lair CS, Petrosyan E, Jacob T, Caraig M, Burchfield PJ. Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants: Double-Blinded Randomized Controlled Trial. J Perinatol 2020, Apr;40(4):655-665. doi: 10.1038/s41372-020-0609-1. PMID: 32071367
  24. Smithhart W, Wyckoff MH, Kapadia V, Jaleel M, Kakkilaya V, Brown LS, Nelson DB, Brion LP. Delivery room continuous positive pressure and pneumothorax in term and near-term neonates. Pediatrics 2019;144(3):e20190756. PMID: 31399490
  25. Rosenfeld CR, Shafer G, Scheid LM, Brown LS. Screening and Serial Neutrophil Counts Do Not Contribute to the Recognition or Diagnosis of Late-Onset Neonatal Sepsis. J Pediatr. 2019 Feb;205:105-111.e2. doi: 10.1016/j.jpeds.2018.09.024. Epub 2018 Oct 11. PMID: 30318373.
  26. Pavageau P, Brion LP, Rosenfeld CR, Brown LS, Ramaciotti C, Burchfield PJ, Jaleel MA. Decrease in Frequency of Treatment for Patent Ductus Arteriosus after Implementation of Consensus Guidelines: A 15-Year Experience. J Perinatol. 2019 Jul 23. doi: 10.1038/s41372-019-0432-8. PMID: 31337852
  27. Kakkilaya V, Wagner S, Mangona KLM, Steven Brown L, Jubran I, He H, Savani RC, Kapadia VS. Early predictors of continuous positive airway pressure failure in preterm neonates. J Perinatol. 2019 Aug;39(8):1081-1088. doi: 10.1038/s41372-019-0392-z. Epub 2019 May 14. PMID: 31089256. 
  28. Kakkilaya V, Jubran I, Mashruwala V, Ramon E, Simcik VN, Marshall M, Brown LS, Jaleel MA, Kapadia VS. Quality Improvement Project to Decrease Delivery Room Intubations in Preterm Infants. Pediatrics. 2019 Feb;143(2):e20180201. doi: 10.1542/peds.2018-0201. Epub 2019 Jan 2. PMID: 30602545; PMCID: PMC6361361. 
  29. Brion LP, Rosenfeld CR, Heyne R, Brown LS, Lair C, Burchfield P, Caraig M. Adjustable Feedings plus Accurate Serial Length Measurements Decrease Weight-Length Disproportion in Very Preterm Infants. J Perinatol. 2019 Aug;39(8):1131-1139. doi: 10.1038/s41372-019-0424-8. PMID: 31263201; Correction: J Perinatol. 2019 Dec;39(12):1694. doi: 10.1038/s41372-019-0521-8. PMID: 31601949 
  30. Sisman, J., Chalak, L., Heyne, R., Rosenfeld, C.R. Lenticulostriate vasculopathy in preterm infants: a new classification, clinical associations and neurodevelopmental outcome. J Perinatol 2018; 38, 1370–1378&
  31. Pavageau L, Rosenfeld CR, Heyne R, Brown LS, Whitham J, Lair C, Brion LP. Valid Serial Length Measurements in Preterm Infants Permit Characterization of Growth Patterns. Journal of Perinatology, 2018 Dec;38(12):1694-1670. PMID: 30267002
  32. Kapadia VS, Lal CV, Kakkilaya V, Brown S, Heyne R, Savani RC, Wyckoff MH. Impact of the Neonatal Resuscitation Program Recommended Low Oxygen Strategy on Outcomes of Preterm Infants. J Pediatr. 2017;191:35-41.
  33. Halling C, Sparks JE, Christie L, Wyckoff MH. Use and efficacy of lower versus higher doses of endotracheal epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. J Pediatr 2017;185:232-236.
  34. DeVries LB, Heyne RJ, Ramaciotti C, Brown LS, Jaleel MA, Kapadia KS, Burchfield PJ, Brion LP. Mortality among Infants with Evolving Bronchopulmonary Dysplasia Increases with Major Surgery and with Pulmonary Hypertension. J Perinatol. 2017 Sep;37(9):1043-1046. PMID: 28617427
  35. Motta M, Scott W, Mahony L, Koch J, Wyckoff M, Reisch J, Burchfield PJ, Brion LP. The Association of Congenital Heart Disease with Necrotizing Enterocolitis in Preterm Infants: A Birth Cohort Study. Journal of Perinatology, 2015 Nov;35(11):949-53. PMID: 26248130
  36. Eduardo Lopez-Medina, Joseph B. Cantey, Pablo J. Sánchez, The Mortality of Neonatal Herpes Simplex Virus Infection. The Journal of Pediatrics, Volume 166, Issue 6, 2015, Pages 1529-1532.e1.
  37. Ronchi A, Doern C, Brock E, Pugni L, Sánchez PJ. Neonatal adenoviral infection: a seventeen year experience and review of the literature. J Pediatr. 2014 Mar;164(3):529-35.e1-4. doi: 10.1016/j.jpeds.2013.11.009. Epub 2013 Dec 18. PMID: 24359940.
  38. Mikhael M, Brown LS, and Rosenfeld CR. Serial neutrophil values facilitate predicting the absence of neonatal early-onset sepsis. J. Pediatr, 164: 522-528, 2014; Epub Dec 10, 2013. PMID 24331688.
  39. LeVan JM, Brion LP, Wrage LA, Gantz MG, Wyckoff MH, Sánchez PJ, Heyne R, Jaleel M, Finer NN, Carlo WA, Das A, Stoll BJ, Higgins RD, on behalf of the Eunice Kennedy Shriver NICHD Neonatal Research Network, Bethesda, MD. Change in Practice After The Surfactant, Positive Pressure, and Oxygenation Randomized Trial. Arch Dis Child Fetal Neonatal 2014;99: F386–F390. PMID: 24876196
  40. LeVan JM, Wyckoff MH, Ahn C, Heyne R, Sánchez PJ, Chalak L, Jaleel MA, Burchfield PJ, Christie L, Soll R, Badger GJ, Brion LP. Change in Care Among Non–Enrolled Patients During and After a Randomized Trial. Pediatrics 2013; 132:e960-70. PMID: 24043277 
  41. Kapadia VS, Chalak LF, Sparks JE, Allen J, Savani RC, Wyckoff MH. Randomized Trial of a Limited versus Traditional O2 Strategy for Resuscitation of Preterm Neonates. Pediatrics 2013;132:e1488-1496.
  42. Kapadia VS, Chalak L, Dupont T, Rollins NK, Brion LP, Wyckoff MH. Perinatal asphyxia with hyperoxemia within the first hour of life is associated with moderate to severe hypoxic-ischemic encephalopathy. J Pediatrics 2013;163(4):949-54 PMID: 2375942
  43. Tara L. DuPont, Lina F. Chalak, Michael C. Morriss, P. Jeannette Burchfield, Lucy Christie, Pablo J. Sánchez, Short-Term Outcomes of Newborns with Perinatal Acidemia Who are Not Eligible for Systemic Hypothermia Therapy. The Journal of Pediatrics, Volume 162, 2013. Pages 35-41.
  44. Chalak LF, Rollins N, Morris MC, Brion LP, Heyne R, Sánchez PJ. Perinatal acidosis and hypoxic-ischemic encephalopathy in preterm infants of 33 to 35 weeks’ gestation. J Pediatrics, 2012; 160:388-941. PMID: 22033298
  45. Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. Prevalence of Spontaneous Closure of the Ductus Arteriosus in Neonates at a Birth Weight of 1000 Grams or Less. Pediatrics 2006; 117 (4) 1113-1121
  46. Barber CA, Wyckoff MH. Endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. Pediatrics 2006; 118:1028-34.
  47. Wyckoff MH, Perlman JM, Laptook AR. Use of volume expansion during delivery room resuscitation in near-term and term infants. Pediatrics 2005;115:950-5
  48. Woldesenbet, M., Perlman, J. Histologic Chorioamnionitis: An Occult Marker of Severe Pulmonary Hypertension in the Term Newborn. J Perinatol 25, 189–192 (2005).
  49. Salhab WA, Wyckoff MH, Laptook AR, Perlman JM. Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics 2004; 114:361-6.  
  50. Kaiser JR, Tilford JM, Simpson PM, Salhab WA, Rosenfeld CR. Hospital Survival of Very-Low Birth-Weight Neonates from 1977 to 2000.  J Perinatol 24:343-350, 2004. Neonates from 1977 to 2000.  J Perinatol 24:343-350, 2004. 
  51. LeFlore JL, Engle WD, Rosenfeld CR. Determinants of blood pressure regulation and need for blood pressure support in very low birth weight neonates. Early Human Develop 59:37-50, 2000.
  52. Kaiser JR, Rosenfeld CR. A population-based study of congenital diaphragmatic hernia: Impact of associated anomalies and ventilatory parameters on survival. J Pediat Surg 34:1196-1202, 1999. 
  53. Engle WD, Rosenfeld CR, Mouzinho A, Risser A, Zeray F, Sanchez PJ. Circulating neutrophils in septic preterm neonates: Comparison of two reference ranges. Pediatrics 99:1-6, 1997.
  54. Tyson JE, Kennedy KA, Broyles S, Rosenfeld CR. The small for gestational age infant: Accelerated or delayed pulmonary maturity? Increased or decreased survival? Pediatrics 95:534-538, 1995.
  55. Mouzinho A, Rosenfeld CR, Sánchez PJ, Risser R. Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates. Pediatrics. 1994 Jul;94(1):76-82. PMID: 8008542.
  56. Hernandez C, Little BB, Dax JS, Gilstrap LC, Rosenfeld CR. Prediction of the severity of meconium aspiration syndrome. Am J Obstet Gynecol 169:61-70, 1993.
  57. Mouzinho A, Rosenfeld CR, Risser R. Symptomatic patent ductus arteriosus in very-low-birth-weight babies. Early Human Develop 27:65-77, 1991.  
  58. Little BB, Snell LM, Knoll KA, Ghali FE, Rosenfeld CR, Gant NF. Heroin abuse during pregnancy: Effects on perinatal outcome and early childhood growth. Am J Hum Biol. 1991;3(5):463-468 
  59. Wallin LA, Rosenfeld CR, Laptook AR, Maravilla AM, Strand C, Campbell N, Dowling S, Lasky RE. Neonatal intracranial hemorrhage: II. Risk factor analysis in an inborn population. Early Human Develop 23:129-137, 1990.
  60. Tyson, Jon, David Guzick, Charles R. Rosenfeld, Robert Lasky, Norman Gant, Juan Jiminez, and Stephen Heartwell. Prenatal care evaluation and cohort analyses. Pediatrics 85, no. 2 (1990): 195-204.
  61. Strand C, Laptook AR, Dowling S, Campbell N, Lasky RE, Wallin LA, Maravilla AM, Rosenfeld CR. Changing pattern of periventricular­ intraventricular hemorrhage in inborn low-birth-weight infants. Early Human Develop 23:117-128, 1990.
  62. Jon.E. Tyson, Robert E. Lasky, Charles R. Rosenfeld, Sharon Dowling, Norman Gant, An analysis of potential biases in the loss of indigent infants to follow-up. Early Human Development, Volume 16, Issue 1, 1988, Pages 13-25.
  63. Lasky RE, Tyson JE, Rosenfeld CR, Priest M, Allen D, Krasinski D, Digiacomo M, Dowling S, Gant NF. Disappointing follow-up findings for indigent high-risk newborns. Am J Dis Child 141:100-105, 1987.
  64. Guzick, D. S., Klein, V. R., Tyson, J. E., Lasky, R. E., Gant, N. F., & Rosenfeld, C. R. (1987). Risk factors for the occurrence of pregnancy-induced hypertension. Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy, 6(2), 281-297. 
  65. Strickland DM, Guzick DS, Cox K, Gant NF, Rosenfeld CR. The relationship between abortion in the first pregnancy and development of pregnancy-induced hypertension in the subsequent pregnancy. Am J Obstet Gynecol. 1986 Jan;154(1):146-8. doi: 10.1016/0002-9378(86)90412-6. PMID: 3946488.
  66. Mize, S.G., Rosenfeld, C.R., Lasky, R.E., Fitzpatrick, B., Tyson, J.E. and Gant, N.F. (1982): Quality control of a large perinatal information system. Proc. Second Cleveland Symp. Perinatal Computing,  pp. 23-26.
  67. Sanchez A, Mize S, Jimenez J, Manroe B, Rosenfeld C, Tyson J. Systems approach to the evaluation of maternal and neonatal care, selected papers in medical information processing. In: Twelfth Hawaii International Conference on Systems Sciences 1979 p. 140–51.