Publications

Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates.Yang, Y.*; Tsien, J.*; Dykstra, R.; Chen, S.-J.; Merchant, R. R.; Hughes, J. M. E.; Peters, B. K.; Gutierrez, O.; Qin, T. Nat. Chem. 2023, ASAP.

Programmable Late Stage

Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells. Stepanov, A. V.; Xie, J.; Zhu, Q.; Shen, Z.; Su, W.; Kuai, L.; Soll, R.; Shaver, G.; Douthit, L.; Zhang, D.; Kalinin, R.; Xiang, F.; Zhao, Y.; Qin, T.; Baran, P. S.; Gabibov, A. G.; Bushnell, D.; Neri, D.; Kornberg, R. D.; Lerner, R. Nat. Biomed. Eng., 2023, ASAP.

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer.. Li, P.*; Zhen, Y.*; Kim, C.*; Liu, Z.; Hao, J.; Deng, H.; Deng, H., Min, Z.; Wang, X.; Qin, T.; Yu, Y. Sci. Adv., 2023, 9, eadg775.

RNF114

Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose)polymerase-1 trapping inducers. Deng, H.*; Deng, H.*; Kim, C.; Li, P.; Wang, X.; Yu, Y.; Qin, T. Nat. Synth. 2023, ASAP.

Nimbolide

Uncanonical Semi-reduction of Quinolines and Isoquinolines via Regioselective HAT-promoted Hydrosilylation. Hu, C.; Vu, C.; Merchant, R. R.; Chen, S.; Hughes, J. M. E.; Peters, B. K.; Qin, T. J. Am. Chem. Soc. 2023, 145, 25–31.

Uncanonical Semi-reduction of Quinolines and Isoquinolines

Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres. Min, Z.*; Tsien, J.*; Dykstra, R.; Hughes, J. M. E.; Peters, B. K.; Merchant, R. R.; Gutierrez, O.; Qin, T. Nat. Chem. 2023, 15, 550–559.

Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres

Mutations Linked to Neurological Disease Enhance Self-association of Low-complexity Protein Sequences. Zhou, X.; Sumrow, L.; Tashiro, K.; Sutherland, L.; Liu, D.; Qin, T.; Kato, M.; Liszczak, G.; McKnight, S. Science 2022, 377, eabn5582.

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang, Z.; Cheong, M. C.; Tsien, J.; Deng, H.; Qin, T.; Stoltzufs, J.; Jaleta, T.; Li, X.; Lok, J.; Kiewer, S.; Mangelsdorf, D., eLife 2021, 10:e73535.

2021 DA eLife

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates. Yang, Y.*; Tsien, J.*; Hughes, J. M. E.; Peters, B. K.; Merchant, R. R.; Qin, T., Nat. Chem. 202113, 950–955

2021 nature chem

Practical and Modular Construction of C(sp3)-Rich Alkyl Boron Compounds. Yang, Y.*; Tsien, J.*; Ben David, A.; Hughes, J. M. E.; Merchant, R. R.; Qin, T., J. Am. Chem. Soc. 2021143, 471–480.

thumbnail_2021 JACS Bpin

Radical Radical Cross-Coupling Reactions. Zhou, M., Qin, T., Science of Syntheis. (invited).

Unsymmetrical Heterocycle Cross-Couplings Enabled by Sulfur(IV) Reagents. Zhou, M., Tsien, J., Qin, T., Synlett 202031, 1962–1966. (invited).

Sulfur (IV)-mediated Heterocycle Cross-Couplings. Zhou, M., Tsien, J., Qin, T., Angew. Chem. Int. Ed. 202059, 7372–7376.

acie 2020

Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough. Ruhl, C.R., Pasko, B.L., Khan, H.S., Kindt, L.M., Stamm, C.E., Franco, L.H., Hsia, C., Zhou, M., Davis, C.R., Qin, T., Gautron, L., Burton, M., Mejia, G.L., Naik, D.K., Dussor, G., Price, T.J., Shiloh, M.U. Cell 2020181, 293–305.

cell

Before UTSW

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines. Ni, S.; Padial, N. M.; Kingston, C.; Vantourout, J. C.; Schmitt, D. C.; Edwards, J. T.; Kruszyk, M.; Merchant, R. R.; Mykhailiuk, P. K.; Sanchez, B.; Yang, S.; Perry, M.; Gallego, G. M.; Mousseau, J. J.; Collins, M. R.; Cherney, R. J.; Lebed, P. S.; Chen, J. S.; Qin, T.; Baran, P. S. J. Am. Chem. Soc. 2019141, 6726–6739.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids. Shang, M.*; Feu, K. S.*; Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S.; Melillo, B.; Yu, J.-Q.; Baran, P. S. Prod. Nat. Acad. Sci. 2019116, 8721-8727.

Quaternary Centers by Nickel‐Catalyzed Cross‐Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents. Chen, T.-G.; Zhang, H.; Mykhailiuk, P.K.; Merchant, R.R.; Smith, C.A.; Qin, T.; Baran, P.S. Angew. Chem. Int. Ed. 201958, 2454–2458.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling. Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G. M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.–S.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Qin, T.; Baran, P. S. Chem. Int. Ed. Angew. Chem. Int. Ed., 2018, 55, 14560–14565.

Cu-Catalyzed Decarboxylative Borylation. Wang, J.*; Shang, M.*; Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.; Baran, P. S. ACS Catal., 2018, 89537–9542.

Building C(sp3)-rich Complexity by Combining Cycloaddition and C–C Cross Coupling Reactions. Chen, T.–G.*; Barton, L.*; Lin, Y.*; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, D.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Nature, 2018560, 350–354.

Kinetically Guided Radical-based Synthesis of C(sp3)–C(sp3) Linkages on DNA. Wang, J.*; Lundberg, H.*; Asai, S.; Martín-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R. G.; O’Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.; Baran, P. S. Nat. Acad. Sci., 2018115, E6404–E6410.

Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. Wu, X.*; Iwata, T.*; Scharf, A.; Qin, T.; Reichl, K.D.; Porco, J. A., Jr., J. Am. Chem. Soc.2018140, 5969–5975.

Modular Radical Cross-Coupling with Sulfones Enables Access to sp3-rich (Fluoro)alkylated Scaffolds. Merchant, R. R.*; Edwards, J. T.*; Qin, T. *; Kruszyk, M. M.; Bi, C.; Che, G.; Bao, D.-H.; Qiao, W.; Sun, L.; Collins, M. R.; Gallego, G. M.; Mousseau, J. J.; Nuhant, P.; Baran, P. S. Science2018360, 75–80.

CITU: A Peptide and Decarboxylative Coupling Reagent. deGruyter, J. N.*; Malins, L. R. *; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.; Che, G.; Bao, D.; Stevens, J. M.; Qiao, J.; Allen, M. P. Poss, M. A.; Baran, P. S. Org. Lett., 201719, 6196-6199.

Decarboxylative Alkynylation. Smith, J. M.*; Qin, T.*; Merchant, R. R.; Edwards, J. T.; Malins, L. R.; Liu, Z.; Che, G.; Shen, Z.; Shaw, S. A.; Eastgate, M. D.; Baran, P. S. Angew. Chem. Int. Ed., 201756, 11906–11910.

Decarboxylative Alkenylation. Edwards, J. T.*; Merchant, R.*; McClymont, K. S.; Knouse K. W.; Qin, T.; Malins, L. R.; Vokits, B.; Shaw, S. A.; Bao, D.-H.; Wei, F.-L.; Zhou, T.; Eastgate, M. D.; Baran, P. S. Nature2017545, 213–218.

Fe-Catalyzed C–C Bond Construction from Olefins via Radicals. Lo, J. C.; Kim, D.; Pan, C.-M.; Edwards, J. T.; Yabe, Y.; Gui, J.; Qin, T.; Gutiérrez, S.; Giacoboni, J.; Smith, M. W.; Holland, P. L.; Baran, P. S., Am. Chem. Soc., 2017139, 2484–2503.

Ni-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Qin, T.; Malins, L. R.; Edwards, J. T.; Merchant, R. R.; Novak, A. J. E.; Zhong, J. Z.; Mills, R. B.; Yan, M.; Yuan, C.; Eastgate, M. D.; Baran, P. S., Angew. Chem. Int. Ed., 201756, 260-265.

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. Wang, J.; Qin, T.; Chen, T.-E.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Angew. Chem. Int. Ed., 201655, 9676-9679.

A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents. Qin, T.*; Cornella, J. *; Li, C. *; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S., Science2016352, 801–805.

Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters. Cornella, J. *; Edwards, J. T. *; Qin, T.; Kawamura, S.; Wang, J. Pan, C-M.; Gianatassio, R.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S., J. Am. Chem. Soc., 2016138, 2174–2177. 

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of Shapeshifting Properties. Qin, T.; Iwata, T.; Ransom, T. T.; Beutler, J. A.; Porco, J. A. Jr., J. Am. Chem. Soc., 2015137, 15225–15233.

Practical Olefin Hydroamination with Nitroarenes. Gui, J.; Pan, C-M. *; Jin, Y.*; Qin, T. ; Lo, J. C.; Lee, B. J.; Spergel, S. H.; Mertzman, M. E.; Pitts, W. J.; La Cruz, T. E.; Schmidt, M. A.; Darvatkar, N.; Natarajan, S. R.; Baran, P. S. Science, 2015348, 886–891.

Atropselective Syntheses of (-) and (+) Rugulotrosin A Utilizing Point-to-Axial Chirality Transfer. Qin, T.; Skraba-Joiner, S. L.; Khalil, Z. G.; Johnson, R. P.; Capon, R. J.; Porco, J. A., Jr., Nat. Chem., 20157, 234–240.

Total Synthesis of Secalonic Acids A and D. Qin, T.; Porco, J. A., Jr., Angew. Chem. Int. Ed., 2014, 53, 3107–3110.

Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A. Qi, C.; Qin, T.; Porco, J. A., Jr., J. Am. Chem. Soc., 2014136, 3374–3377.

Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation. Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A., Jr., J. Am. Chem. Soc., 2012134, 19782–19787.

Vinylogous Addition of Siloxyfurans to Benzopyryliums: A Concise Approach to the Tetrahydronxanthone Natural Products. Qin, T.; Johnson, R. P.; Porco, J. A., Jr., J. Am. Chem. Soc., 2011133, 1714–1717.

Pd(N,N-Dimethyl β-alaninate)2 as a High-Turnover-Number, Phosphine-Free Catalyst for the Suzuki Reaction. Cui, X.; Qin, T.; Wang, J.-R.; Liu, L.; Guo, Q.-X. Synthesis, 20073, 393–399.