Publications

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang, Z.; Cheong, M. C.; Tsien, J.; Deng, H.; Qin, T.; Stoltzufs, J.; Jaleta, T.; Li, X.; Lok, J.; Kiewer, S.; Mangelsdorf, D., eLife 2021, 10:e73535.

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates. Yang, Y.*; Tsien, J.*; Hughes, J. M. E.; Peters, B. K.; Merchant, R. R.; Qin, T., Nat. Chem. 2021, 13, 950–955

Practical and Modular Construction of C(sp³)-Rich Alkyl Boron Compounds. Yang, Y.*; Tsien, J.*; Ben David, A.; Hughes, J. M. E.; Merchant, R. R.; Qin, T., J. Am. Chem. Soc. 2021, 143, 471–480.

Radical Radical Cross-Coupling Reactions. Zhou, M., Qin, T., Science of Syntheis. (invited).

Unsymmetrical Heterocycle Cross-Couplings Enabled by Sulfur(IV) Reagents. Zhou, M., Tsien, J., Qin, T., Synlett 2020, 31, 1962–1966. (invited).

Sulfur (IV)-mediated Heterocycle Cross-Couplings. Zhou, M., Tsien, J., Qin, T., Angew. Chem. Int. Ed. 2020, 59, 7372–7376.

Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough. Ruhl, C.R., Pasko, B.L., Khan, H.S., Kindt, L.M., Stamm, C.E., Franco, L.H., Hsia, C., Zhou, M., Davis, C.R., Qin, T., Gautron, L., Burton, M., Mejia, G.L., Naik, D.K., Dussor, G., Price, T.J., Shiloh, M.U. Cell 2020, 181, 293–305.

Before UTSW

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines. Ni, S.; Padial, N. M.; Kingston, C.; Vantourout, J. C.; Schmitt, D. C.; Edwards, J. T.; Kruszyk, M.; Merchant, R. R.; Mykhailiuk, P. K.; Sanchez, B.; Yang, S.; Perry, M.; Gallego, G. M.; Mousseau, J. J.; Collins, M. R.; Cherney, R. J.; Lebed, P. S.; Chen, J. S.; Qin, T.; Baran, P. S. J. Am. Chem. Soc. 2019, 141, 6726–6739.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids. Shang, M.*; Feu, K. S.*; Vantourout, J. C.; Barton, L. M.; Osswald, H. L.; Kato, N.; Gagaring, K.; McNamara, C. W.; Chen, G.; Hu, L.; Ni, S.; Fernández-Canelas, P.; Chen, M.; Merchant, R. R.; Qin, T.; Schreiber, S.; Melillo, B.; Yu, J.-Q.; Baran, P. S. Prod. Nat. Acad. Sci. 2019, 116, 8721-8727.

Quaternary Centers by Nickel‐Catalyzed Cross‐Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents. Chen, T.-G.; Zhang, H.; Mykhailiuk, P.K.; Merchant, R.R.; Smith, C.A.; Qin, T.; Baran, P.S. Angew. Chem. Int. Ed. 2019, 58, 2454–2458.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling. Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G. M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.–S.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Qin, T.; Baran, P. S. Chem. Int. Ed. Angew. Chem. Int. Ed., 2018, 55, 14560–14565.

Cu-Catalyzed Decarboxylative Borylation. Wang, J.*; Shang, M.*; Lundberg, H.; Feu, K. S.; Hecker, S. J.; Qin, T.; Blackmond, D. G.; Baran, P. S. ACS Catal., 2018, 8, 9537–9542.

Building C(sp³)-rich Complexity by Combining Cycloaddition and C–C Cross Coupling Reactions. Chen, T.–G.*; Barton, L.*; Lin, Y.*; Tsien, J.; Kossler, D.; Bastida, I.; Asai, S.; Bi, C.; Chen, J. S.; Shan, D.; Fang, H.; Fang, F. G.; Choi, H.; Hawkins, L.; Qin, T.; Baran, P. S. Nature, 2018, 560, 350–354.

Kinetically Guided Radical-based Synthesis of C(sp³)–C(sp³) Linkages on DNA. Wang, J.*; Lundberg, H.*; Asai, S.; Martín-Acosta, P.; Chen, J. S.; Brown, S.; Farrell, W.; Dushin, R. G.; O’Donnell, C. J.; Ratnayake, A. S.; Richardson, P.; Liu, Z.; Qin, T.; Blackmond, D. G.; Baran, P. S. Nat. Acad. Sci., 2018, 115, E6404–E6410.

Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. Wu, X.*; Iwata, T.*; Scharf, A.; Qin, T.; Reichl, K.D.; Porco, J. A., Jr., J. Am. Chem. Soc., 2018, 140, 5969–5975.

Modular Radical Cross-Coupling with Sulfones Enables Access to sp³-rich (Fluoro)alkylated Scaffolds. Merchant, R. R.*; Edwards, J. T.*; Qin, T. *; Kruszyk, M. M.; Bi, C.; Che, G.; Bao, D.-H.; Qiao, W.; Sun, L.; Collins, M. R.; Gallego, G. M.; Mousseau, J. J.; Nuhant, P.; Baran, P. S. Science, 2018, 360, 75–80.

CITU: A Peptide and Decarboxylative Coupling Reagent. deGruyter, J. N.*; Malins, L. R. *; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.; Che, G.; Bao, D.; Stevens, J. M.; Qiao, J.; Allen, M. P. Poss, M. A.; Baran, P. S. Org. Lett., 2017, 19, 6196-6199.

Decarboxylative Alkynylation. Smith, J. M.*; Qin, T.*; Merchant, R. R.; Edwards, J. T.; Malins, L. R.; Liu, Z.; Che, G.; Shen, Z.; Shaw, S. A.; Eastgate, M. D.; Baran, P. S. Angew. Chem. Int. Ed., 2017, 56, 11906–11910.

Decarboxylative Alkenylation. Edwards, J. T.*; Merchant, R.*; McClymont, K. S.; Knouse K. W.; Qin, T.; Malins, L. R.; Vokits, B.; Shaw, S. A.; Bao, D.-H.; Wei, F.-L.; Zhou, T.; Eastgate, M. D.; Baran, P. S. Nature, 2017, 545, 213–218.

Fe-Catalyzed C–C Bond Construction from Olefins via Radicals. Lo, J. C.; Kim, D.; Pan, C.-M.; Edwards, J. T.; Yabe, Y.; Gui, J.; Qin, T.; Gutiérrez, S.; Giacoboni, J.; Smith, M. W.; Holland, P. L.; Baran, P. S., Am. Chem. Soc., 2017, 139, 2484–2503.

Ni-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Qin, T.; Malins, L. R.; Edwards, J. T.; Merchant, R. R.; Novak, A. J. E.; Zhong, J. Z.; Mills, R. B.; Yan, M.; Yuan, C.; Eastgate, M. D.; Baran, P. S., Angew. Chem. Int. Ed., 2017, 56, 260-265.

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. Wang, J.; Qin, T.; Chen, T.-E.; Wimmer, L.; Edwards, J. T.; Cornella, J.; Vokits, B.; Shaw, S. A.; Baran, P. S. Angew. Chem. Int. Ed., 2016, 55, 9676-9679.

A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents. Qin, T.*; Cornella, J. *; Li, C. *; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S., Science, 2016, 352, 801–805.

Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters. Cornella, J.^*; Edwards, J. T.^*; Qin, T.; Kawamura, S.; Wang, J. Pan, C-M.; Gianatassio, R.; Schmidt, M. A.; Eastgate, M. D.; Baran, P. S., J. Am. Chem. Soc., 2016, 138, 2174–2177.

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of Shapeshifting Properties. Qin, T.; Iwata, T.; Ransom, T. T.; Beutler, J. A.; Porco, J. A. Jr., J. Am. Chem. Soc., 2015, 137, 15225–15233.

Practical Olefin Hydroamination with Nitroarenes. Gui, J.; Pan, C-M. *; Jin, Y.*; Qin, T. ; Lo, J. C.; Lee, B. J.; Spergel, S. H.; Mertzman, M. E.; Pitts, W. J.; La Cruz, T. E.; Schmidt, M. A.; Darvatkar, N.; Natarajan, S. R.; Baran, P. S. Science, 2015, 348, 886–891.

Atropselective Syntheses of (-) and (+) Rugulotrosin A Utilizing Point-to-Axial Chirality Transfer. Qin, T.; Skraba-Joiner, S. L.; Khalil, Z. G.; Johnson, R. P.; Capon, R. J.; Porco, J. A., Jr., Nat. Chem., 2015, 7, 234–240.

Total Synthesis of Secalonic Acids A and D. Qin, T.; Porco, J. A., Jr., Angew. Chem. Int. Ed., 2014, 53, 3107–3110.

Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A. Qi, C.; Qin, T.; Porco, J. A., Jr., J. Am. Chem. Soc., 2014, 136, 3374–3377.

Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation. Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A., Jr., J. Am. Chem. Soc., 2012, 134, 19782–19787.

Vinylogous Addition of Siloxyfurans to Benzopyryliums: A Concise Approach to the Tetrahydronxanthone Natural Products. Qin, T.; Johnson, R. P.; Porco, J. A., Jr., J. Am. Chem. Soc., 2011, 133, 1714–1717.

Pd(N,N-Dimethyl β-alaninate)₂ as a High-Turnover-Number, Phosphine-Free Catalyst for the Suzuki Reaction. Cui, X.; Qin, T.; Wang, J.-R.; Liu, L.; Guo, Q.-X. Synthesis, 2007, 3, 393–399.