Leptin signaling maintains autonomic stability during severe influenza infection in mice.
Muñoz-Rojas AR, Wang AC, Pomeranz LE, Reizis EL, Stout-Delgado HW, Miranda IC, Rajagopalan K, Gwatiringa T, Fan RR, Huda AA, Maskey N, Olumuyide RP, Patel AS, Friedman JM, Mathis D, Rajagopalan KN. J Clin Invest. 2024 Oct 31:e182550.
A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19
O'Donnell MR, Grinsztejn B, Cummings MJ, Justman JE, Lamb MR, Eckhardt CM, Philip NM, Cheung YK, Gupta V, João E, Pilotto JH, Diniz MP, Cardoso SW, Abrams D, Rajagopalan KN, Borden SE, Wolf A, Sidi LC, Vizzoni A, Veloso VG, Bitan ZC, Scotto DE, Meyer BJ, Jacobson SD, Kantor A, Mishra N, Chauhan LV, Stone EF, Dei Zotti F, La Carpia F, Hudson KE, Ferrara SA, Schwartz J, Stotler BA, Lin WW, Wontakal SN, Shaz B, Briese T, Hod EA, Spitalnik SL, Eisenberger A, Lipkin WI. 2021. Journal of Clinical Investigation: 131(13): e150646.
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
*Rajagopalan, K.N., *Chen, X., *Weinberg, D.N., Allis, C.D., Lu, C. 2021. Proceedings of the National Academy of the Sciences: 118(9). (*denotes equal contribution)
Body mass index and risk of intubation or death in SARS-CoV-2 infection: a retrospective cohort study.
Anderson M.R., Geleris J., Anderson D.R., Zucker J., Nobel Y.R., Freedberg D., Small-Saunders J., Rajagopalan K.N., Greendyk R., Chae S., Natarajan K., Roh D., Edwin E., Gallagher D., Podolanczuk A., Barr R.G., Ferrante A.W., Baldwin M.R. Body mass index and risk of intubation or death in SARS-CoV-2 infection: a retrospective cohort study. 2020. Annals of Internal Medicine: M20-3214.
Evaluating the efficacy and safety of human anti-SARS-CoV2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized control trial.
Eckhardt, C.M., Cummings M.J., Rajagopalan, K.N., Borden, S., Bitan, Z.C., Wolf, A., Kantor, A., Briese T., Meyer, B.J., Jacobson, S.D., Scotto, D., Mishra, N., Philip N.M., Stotler, B.A., Schwartz J., Shaz, B., Spitalnik, S.L., Eisenberger A., Hod, E.A., Justman, J., Cheung, K, Lipkin, W.I., O’Donnell, M.R. 2020. Trials 21(1): 499.
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.
Weinberg, D.N., Papillon-Cavanaugh, S., Chen, H., Yue, Y., Chen, X., Rajagopalan, K.N., Horth, C., Nikbakht, H., Lemeisz, A.E., Marchione, D.M., Marunde, M.R., Meiners, M.J., Cheek, M.A., Keogh, M.C., Bareke, E., Djedid, A., Harutunyan, A., Jabado, N., Garcia, B.A., Li, H., Allis, C.D., Majewski, J., Lu, C. 2019. Nature 573 (7773): 281-86.
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
Rajagopalan, K.N., Egnatchik, R.A., Calvaruso, M.A., Wasti, A.T., Padanad, M.S., Boroughs, L.K., Ko, B., Hensley, C.T., Acar, M., Hu, Z., Jiang, L., Pascual, J.M., Scaglioni, P.P., DeBerardinis, R.J. 2015. Cancer and Metabolism 3: 7.
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X.L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., Cai, L., Good, L., Tu, B.P., Hatanpaa, K.J., Mickey, B.E., Matès, J.M., Pascual, J.M., Maher, E.A., Malloy, C.R., Deberardinis, R.J., Bachoo, R.M. 2012. Cell Metabolism 15(6): 827-37.
Role of glutamine in cancer: therapeutic and imaging implications.
Rajagopalan, K.N. and DeBerardinis R.J. 2011. The Journal of Nuclear Medicine 52(7), 1005-08.
Haem oxygenase is synthetically lethal with the tumor suppressor fumarate hydratase.
Frezza, C., Zheng, L., MacKenzie, E., Jerby, L., Rajagopalan, K.N., Chaneton, B., Hedley, A., Kalna, G., Pollard, P., Tomlinson, I., Watson, D., Shlomi, T., Fogler, O., Ruppin, E., DeBerardinis, R., Gottlieb, E. 2011. Nature 477 (7363):225-8.