Publications

Publications for Debabrata Saha, Ph.D.

Integrated Small Animal PET/CT/RT with Onboard PET/CT Image Guidance for Preclinical Radiation Oncology Research

Cheng X, Yang D, Saha D, Sun X, Shao Y 2023 Apr 9 567-578

Lung Cancer Targeted Chemoradiotherapy via Dual-Stimuli Responsive Biodegradable Core-Shell Nanoparticles

Iyer R, Ramachandramoorthy H, Nguyen T, Xu C, Fu H, Kotadia T, Chen B, Hong Y, Saha D, Nguyen KT 2022 Aug 14

Dimensionality-Dependent Mechanical Stretch Regulation of Cell Behavior

Man K, Liu J, Phan KM, Wang K, Lee JY, Sun X, Story M, Saha D, Liao J, Sadat H, Yang Y 2022 Apr 14 17081-17092

Deep-Tissue Activation of Photonanomedicines: An Update and Clinical Perspectives

Shah N, Squire J, Guirguis M, Saha D, Hoyt K, Wang KK, Agarwal V, Obaid G 2022 Apr 14

Evaluation of the Response of HNSCC Cell Lines to γ-Rays and 12C Ions: Can Radioresistant Tumors Be Identified and Selected for 12C Ion Radiotherapy?

Ding L, Sishc BJ, Polsdofer E, Yordy JS, Facoetti A, Ciocca M, Saha D, Pompos A, Davis AJ, Story MD 2022 Feb 12

Mitotic phosphorylation of tumor suppressor DAB2IP maintains spindle assembly checkpoint and chromosomal stability through activating PLK1-Mps1 signal pathway and stabilizing mitotic checkpoint complex

Yu L, Lang Y, Hsu CC, Chen WM, Chiang JC, Hsieh JT, Story MD, Shang ZF, Chen BP, Saha D 2022 Jan 41 489-501

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

Fletcher-Sananikone E, Kanji S, Tomimatsu N, Cristofaro LF, Kollipara RK, Saha D, Floyd JR, Sung P, Hromas R, Burns TC, Kittler R, Habib AA, Mukherjee B, Burma S 2021 Dec 81 5935-5947

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Preclinical Models Enhances Single-Agent Immune Checkpoint Blockade

Moore C, Hsu CC, Chen WM, Chen BP, Han C, Story M, Aguilera T, Pop LM, Hannan R, Fu Y, Saha D, Timmerman R 2021 Aug 110 1306-1316

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Sishc BJ, Ding L, Nam TK, Heer CD, Rodman SN, Schoenfeld JD, Fath MA, Saha D, Pulliam CF, Langen B, Beardsley RA, Riley DP, Keene JL, Spitz DR, Story MD 2021 May 13

Dose rate determination for preclinical total body irradiation

Zhong Y, Lai Y, Saha D, Story MD, Jia X, Stojadinovic S 2020 Sep 65

Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment

Iyer R, Nguyen T, Padanilam D, Xu C, Saha D, Nguyen KT, Hong Y 2020 May 321 363-371

The paracrine induction of prostate cancer progression by caveolin-1

Lin CJ, Yun EJ, Lo UG, Tai YL, Deng S, Hernandez E, Dang A, Chen YA, Saha D, Mu P, Lin H, Li TK, Shen TL, Lai CH, Hsieh JT 2019 Nov 10

miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer

Vo DT, Karanam NK, Ding L, Saha D, Yordy JS, Giri U, Heymach JV, Story MD 2019 Sep 21 849-862

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

Niu H, Strecker TE, Gerberich JL, Campbell JW, Saha D, Mondal D, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG 2019 Jun 62 5594-5615

The effect of flow on blood oxygen level dependent (R*2) MRI of orthotopic lung tumors

Zhou H, Belzile O, Zhang Z, Wagner J, Ahn C, Richardson JA, Saha D, Brekken RA, Mason RP 2019 Jun 81 3787-3797

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun EJ, Lin CJ, Dang A, Hernandez E, Guo J, Chen WM, Allison J, Kim N, Kapur P, Brugarolas J, Wu K, He D, Lai CH, Lin H, Saha D, Baek ST, Chen BP, Hsieh JT 2019 25 4542-4551

Dual-Drug Containing Core-Shell Nanoparticles for Lung Cancer Therapy

Menon JU, Kuriakose A, Iyer R, Hernandez E, Gandee L, Zhang S, Takahashi M, Zhang Z, Saha D, Nguyen KT 2017 Dec 7

EGFR mutations compromise hypoxia-associated radiation resistance through impaired replication fork–associated DNA damage repair

Saki M, Makino H, Javvadi P, Tomimatsu N, Ding LH, Clark JE, Gavin E, Takeda K, Andrews J, Saha D, Story MD, Burma S, Nirodi CS 2017 Nov 15 1503-1516

Tumor-Treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

Karanam NK, Srinivasan K, Ding L, Sishc B, Saha D, Story MD 2017 8

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging

Zhou H, Zhang Z, Denney R, Williams JS, Gerberich J, Stojadinovic S, Saha D, Shelton JM, Mason RP 2017 8 37464-37477

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments

Yu L, Shang ZF, Abdisalaam S, Lee KJ, Gupta A, Hsieh JT, Asaithamby A, Chen BP, Saha D 2016 Oct 44 8842-8854

Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy

Zhang Z, Wodzak M, Belzile O, Zhou H, Sishc B, Yan H, Stojadinovic S, Mason RP, Brekken RA, Chopra R, Story MD, Timmerman R, Saha D 2016 Jun 185 616-622

Pretreatment biopsy analysis of DAB2IP identifies subpopulation of high-risk prostate cancer patients with worse survival following radiation therapy

Jacobs C, Tumati V, Kapur P, Yan J, Xie XJ, Hannan R, Hsieh JT, Kim DW, Saha D 2015 Dec 4 1844-1852

[68Ga]-HP-DO3A-nitroimidazole: A promising agent for PET detection of tumor hypoxia

Wu Y, Hao G, Ramezani S, Saha D, Zhao D, Sun X, Sherry AD 2015 Nov 10 465-472

Polymeric nanoparticles for targeted radiosensitization of prostate cancer cells

Menon JU, Tumati V, Hsieh JT, Nguyen KT, Saha D 2015 May 103 1632-1639

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry

Lee KJ, Shang ZF, Lin YF, Sun J, Morotomi-Yano K, Saha D, Chen BP 2015 Apr 17 329-338

EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma

Li L, Puliyappadamba VT, Chakraborty S, Rehman A, Vemireddy V, Saha D, Souza RF, Hatanpaa KJ, Koduru P, Burma S, Boothman DA, Habib AA 2015 Jan 34 129-134

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNAPKcs inhibitor

Yu L, Shang ZF, Hsu FM, Zhang Z, Tumati V, Lin YF, Chen BP, Saha D 2015 6 3848-3860

Reciprocal regulation of hypoxia-inducible factor 2α and GLI1 expression associated with the radioresistance of renal cell carcinoma

Zhou J, Wu K, Gao D, Zhu G, Wu D, Wang X, Chen Y, Du Y, Song W, Ma Z, Authement C, Saha D, Hsieh JT, He D 2014 Nov 90 942-951

An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII

Li L, Chakraborty S, Yang CR, Hatanpaa KJ, Cipher DJ, Puliyappadamba VT, Rehman A, Jiwani AJ, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle SC, Kesari S, Boothman DA, Habib AA 2014 Aug 33 4253-4264

DOC-2/DAB2 interacting protein status in high-risk prostate cancer correlates with outcome for patients treated with radiation therapy

Jacobs C, Tumati V, Kapur P, Yan J, Hong D, Bhuiyan M, Xie XJ, Pistenmaa D, Yu L, Hsieh JT, Saha D, Kim DW 2014 Jul 89 729-735

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

Lai CH, Chang CS, Liu HH, Tsai YS, Hsu FM, Yu YL, Lai CK, Gandee L, Pong RC, Hsu HW, Yu L, Saha D, Hsieh JT 2014 5 5523-5534

Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts

Huerta S, Gao X, Dineen S, Kapur P, Saha D, Meyer J 2013 Aug 154 143-151

Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy

Tumati V, Mathur S, Song K, Hsieh JT, Zhao D, Takahashi M, Dobin T, Gandee L, Solberg TD, Habib AA, Saha D 2013 May 42 1613-1619

Effect of PF-02341066 and radiation on non-small cell lung cancer cells

Tumati V, Kumar S, Yu L, Chen B, Choy H, Saha D 2013 Mar 29 1094-1100

DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor

Yu L, Tumati V, Tseng SF, Hsu FM, Kim DN, Hong D, Hsieh JT, Jacobs C, Kapur P, Saha D 2012 Dec 14 1203-1212

AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells

Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D 2012 Nov 84 e507-e514

Molecular profiling to optimize treatment in non-small cell lung cancer: A review of potential molecular targets for radiation therapy by the translational research program of the Radiation Therapy Oncology Group

Ausborn NL, Le QT, Bradley JD, Choy H, Dicker AP, Saha D, Simko J, Story MD, Torossian A, Lu B 2012 Jul 83 e453-e464

In vivo bioluminescence imaging of tumor hypoxia dynamics of breast cancer brain metastasis in a mouse model

Saha D, Dunn H, Zhou H, Harada H, Hiraoka M, Mason RP, Zhao D 2011 Oct

Stereotactic body radiation therapy: Normal tissue and tumor control effects with large dose per fraction

Timmerman R, Bastasch M, Saha D, Abdulrahman R, Hittson W, Story M 2011 May 382-394

Dosimetric characterization of an image-guided stereotactic small animal irradiator

Pidikiti R, Stojadinovic S, Speiser M, Song KH, Hager F, Saha D, Solberg TD 2011 Apr 56 2585-2599

Murine orthotopic model for the assessment of chemoradiotherapeutic interventions in rectal cancer

Huerta S, Gao X, Saha D 2011 Apr 22 371-376

An x-ray image guidance system for small animal stereotactic irradiation

Song KH, Pidikiti R, Stojadinovic S, Speiser M, Seliounine S, Saha D, Solberg TD 2010 Dec 55 7345-7362

Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells

Kong Z, Raghavan P, Xie D, Boike T, Burma S, Chen D, Chakraborty A, Hsieh JT, Saha D 2010 Nov 78 1210-1218

Tissue microarray constructs to predict a response to chemoradiation in rectal cancer

Huerta S, Hrom J, Gao X, Saha D, Anthony T, Reinhart H, Kapur P 2010 Oct 42 679-684

Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks

Camacho CV, Mukherjee B, McEllin B, Ding LH, Hu B, Habib AA, Xie XJ, Nirodi CS, Saha D, Story MD, Balajee AS, Bachoo RM, Boothman DA, Burma S 2010 Jul 31 1889-1896

An orthotopic lung tumor model for image-guided microirradiation in rats

Saha D, Watkins L, Yin Y, Thorpe P, Story MD, Song K, Raghavan P, Timmerman R, Chen B, Minna JD, Solberg TD 2010 Jul 174 62-71

SU‐GG‐J‐06: Optical and X‐Ray Image Guided Stereotactic Body Irradiator Dedicated to Small Animals

Song K, Pidikiti R, Stojadinovic S, Speiser M, Seliounine S, Saha D, Solberg T 2010 Jun 37 3146

Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation

Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D 2010 Apr 70 2829-2839

The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells

Kodym E, Kodym R, Reis AE, Habib AA, Story MD, Saha D 2009 Oct 66 37-47

Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate

Gao X, Saha D, Kapur P, Anthony T, Livingston EH, Huerta S 2009 Aug 100 149-158

Mechanisms of resistance to ionizing radiation in rectal cancer

Huerta S, Gao X, Saha D 2009 Jul 9 469-480

TH‐C‐BRC‐04: Small Animal Stereotactic Irradiator

Pidikiti R, Stojadinovic S, Song K, Seliounine S, Speiser M, Saha D, Solberg T 2009 Jun 36 2798

TU‐C‐BRD‐04: Development and Application of a Pre‐Clinical Stereotactic Irradiator

Solberg T, Pidikiti R, Song K, Speiser M, Stojadinovic S, Saha D, Seliounine S 2009 Jun 36 2720

RIP1 activates PI3K-Akt via a dual mechanism involving NF-κB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA 2009 May 69 4107-4111

The receptor interacting protein 1 inhibits p53 induction through NF-KB activation and confers a worse prognosis in glioblastoma

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA 2009 Apr 69 2809-2816

Image-guided stereotactic small animal irradiator

Pidikiti R, Stojadinovic S, Song K, Speiser M, Seliounine S, Saha D, Solberg TD 2009 55-58

SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1α expression

Ali MA, Reis A, Ding LH, Story MD, Habib AA, Chattopadhyay A, Saha D 2009 34 1051-1060

Exploring the Possibility of Unique Molecular, Biological, and Tissue Effects With Hypofractionated Radiotherapy

Story M, Kodym R, Saha D 2008 Oct 18 244-248

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR

Ramnarain DB, Paulmurugan R, Park S, Mickey BE, Asaithamby A, Saha D, Kelliher MA, Mukhopadhyay P, Banani F, Madden CJ, Wright PS, Chakravarty S, Habib AA 2008 Feb 15 344-353

Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell line

Kodym E, Kodym R, Choy H, Saha D 2008 Jan 169 46-58

The death domain-containing kinase RIP1 regulates p27Kip1 levels through the PI3K-Akt-forkhead pathway

Park S, Ramnarain DB, Hatanpaa KJ, Mickey BE, Saha D, Paulmurugan R, Madden CJ, Wright PS, Bhai S, Ali MA, Puttaparthi K, Hu W, Elliott JL, Stuve O, Habib AA 2008 9 766-773

SU‐GG‐T‐408: Computational Analysis of the Dose and Dose‐Rate Dependence of DNA Double‐Strand Break Repairs

Abolfath R, Timmerman R, Solberg T, Saha D, Story M, Derose P, Hamidian H 2008 35 2818

DNA-PKcs-Dependent Modulation of Cellular Radiosensitivity by a Selective Cyclooxygenase-2 Inhibitor

Kodym E, Kodym R, Chen BP, Chen DJ, Morotomi-Yano K, Choy H, Saha D 2007 Sep 69 187-193

Optimizing dose and fractionation for stereotactic body radiation therapy

Timmerman R, Bastasch M, Saha D, Abdulrahman R, Hittson W, Story M 2007 Aug 352-365

SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor

Ali NA, Choy H, Habib AA, Saha D 2007 May 9 370-381

The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1β- mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells

Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H, Saha D 2006 Feb 66 1758-1766

Correlation of HER1/EGFR expression and degree of radiosensitizing effect of the HER1/EGFR-tyrosine kinase inhibitor erlotinib

Kim JC, Ali MA, Nandi A, Mukhopadhyay P, Choy H, Cao C, Saha D 2005 Dec 42 358-365

Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells

Kim JC, Saha D, Cao Q, Choy H 2004 May 71 213-221

Potential for combined modality therapy of cyclooxygenase inhibitors and radiation

Saha D, Choy H 2003 Dec 193-209

The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity

Saha D, Sekhar KR, Cao C, Morrow JD, Choy H, Freeman ML 2003 Oct 63 6920-6927

Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells

Kim JC, Kim JS, Saha D, Cao Q, Shyr Y, Choy H 2003 Sep 68 305-313

COX-2 inhibitor as a radiation enhancer: New strategies for the treatment of lung cancer

Saha D, Pyo H, Choy H 2003 Aug 26 S70-S74

Resistance to transforming growth factor-beta occurs in the presence of normal smad activation

Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X 2002 Aug 132 310-316

New strategies for colorectal cancer prevention and treatment

Saha D, Roman C, Beauchamp RD 2002 Jul 26 762-766

Oncogenic Ras Represses Transforming Growth Factor-β/Smad Signaling by Degrading Tumor Suppressor Smad4

Saha D, Datta PK, Beauchamp RD 2001 Aug 276 29531-29537

TGF-β and colorectal carcinogenesis

Roman C, Saha D, Beauchamp RD 2001 Feb 52 450-457

Synergistic Induction of Cyclooxygenase-2 by Transforming Growth Factor-β1 and Epidermal Growth Factor Inhibits Apoptosis in Epithelial Cells

Saha D, Datta PK, Sheng H, Morrow JD, Wada M, Moses HL, Beauchamp RD 1999 Dec 1 508-517

Developmental regulation of a plant encoded inhibitor of eukaryotic initiation factor 2α phosphorylation

Langland JO, Langland L, Zeman C, Saha D, Roth DA 1997 Aug 12 393-400

Viral infection: II. Hemin induces overexpression of p67 as it partially prevents appearance of an active p67-deglycosylase in baculovirus-infected insect cells

Saha D, Wu S, Bose A, Chatterjee N, Chakraborty A, Chatterjee M, Gupta NK 1997 Jun 342 373-382

Viral infection: 1. Regulation of protein synthesis during vaccinia viral infection of animal cells

Bose A, Saha D, Gupta NK 1997 Jun 342 362-372

p67 transcription regulates translation in serum-starved and mitogen- activated KRC-7 cells

Gupta S, Bose A, Chatterjee N, Saha D, Wu S, Gupta NK 1997 May 272 12699-12704

Thermodynamic Characterization of the Cooperativity of 40S Complex Formation during the Initiation of Eukaryotic Protein Synthesis

Parkhurst KM, Hileman RE, Saha D, Gupta NK, Parkhurst LJ 1994 Dec 33 15168-15177

Mechanism of action of an eukaryotic initiation factor-2 (eIF-2) associated 67 kDa glycoprotein (p67) and an eIF-2 kinase (dsI).

Chakraborty A, Saha D, Bose A, Hileman RE, Chatterjee M, Gupta NK 1994 Aug 31 236-242

Regulation of eIF-2 α-Subunit Phosphorylation in Reticulocyte Lysate

Chakraborty A, Saha D, Bose A, Chatterjee M, Gupta NK 1994 May 33 6700-6706

Characteristics of the Eukaryotic Initiation Factor 2 Associated 67-kDa Polypeptide

Ray MK, Chakraborty A, Datta B, Chattopadhyay A, Saha D, Bose A, Kinzy TG, Wu S, Hileman RE, Merrick WC, Gupta NK 1993 32 5151-5159