Publications

Selected publications

  1. Vladimir Seplyarskiy*, Mikhail A Moldovan*, Evan Koch, Prathitha Kar, Matthew DC Neville, Raheleh Rahbari & Shamil Sunyaev. Hotspots of human mutation point to clonal expansions in spermatogonia. Nature 2025
  2. Eduardo A. Maury*, Attila Jones*, Vladimir Seplyarskiy*, Chaggai Rosenbluh, Taejong Bae, Yifan Wang, Alexej Abyzov, Sattar Khoshkoo, Yasmine Chahine, Brain Somatic Mosaicism Network, Peter J. Park, Schahram Akbarian, Eunjung Alice Lee, Shamil R. Sunyaev, Christopher A. Walsh, Andrew Chess. Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes. Science 2024  

  3. Vladimir Seplyarskiy*, Daniel J. Lee*, Evan M. Koch*, Joshua S. Lichtman, Harding H. Luan, Shamil R. Sunyaev. A mutation rate model at the basepair resolution identifies the mutagenic effect of Polymerase III transcription. Nature Genetics DOI: 10.1038/s41588-023-01562-0

  4. Vladimir B. Seplyarskiy*, Ruslan A. Soldatov*, Ryan J. McGinty, Jacob Goldman, TOPMed consortia, Peter V. Kharchenko, Christian Gilissen, Wendy Wong, Shamil Sunyaev. Population sequencing data reveal a compendium of mutational processes in human germline. Science
  5. Vladimir B. Seplyarskiy, Shamil Sunyaev. The origin of human mutation in light of genomic data. Nat Rev Genet. 2021 Jun 23.
  6. Vladimir Seplyarskiy, Evgeny E. Akkuratov, Natalia V. Akkuratova, Maria A. Andrianova, Sergey I. Nikolaev, Georgii A. Bazykin, Igor Adameyko, Shamil R. Sunyaev. Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations. Nat Genet. 2019 Jan;51(1):36-41.
  7. Vladimir Seplyarskiy, Soldatov RA, Popadin KY, Bazykin GA, Antonarakis SE, Nikolaev SI. APOBEC induced mutations are strongly enriched on the lagging strand during replication in human cancers. Genome research, 2016 Feb;26(2):174-82.
  8. Terekhanova NV*, Seplyarskiy VB*, Soldatov RA, Bazykin GA. Evolution of local mutation rate in primates and it determinants. Mol Biol Evol. 2017 May 1;34(5):1100-1109.

Selected Preprints

  1. James C. Kitch, Vladimir Seplyarskiy. A Phylogeny-Based Approach to Discover Mutational Processes in Primates. Biorxiv 2024
  2. Vladimir Seplyarskiy, Maha Shady, Maria A Andrianova, Michael Spencer Chapman, Eliezer M Van Allen, Shamil R Sunyaev. Segregating DNA lesions point to high selective advantage of tumor initiating cells. bioRxiv 2025