HDAC6 promotes growth, migration/invasion, and self-renewal of rhabdomyosarcoma.
Pham TQ, Robinson K, Xu L, Pavlova MN, Skapek SX, Chen EY. Oncogene 2021 Jan 40(3):578-591. PMID:33199827
Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.
Butler E, Schwettmann B, Geboers S, Hao G, Kim J, Nham K, Sun X, Laetsch TW, Xu L, Williams NS, Skapek SX. Pediatr Blood Cancer 2020 Dec 67(12):e28639. PMID:32975370
Development of a Data Model and Data Commons for Germ Cell Tumors.
Ci B, Yang DM, Krailo M, Xia C, Yao B, Luo D, Zhou Q, Xiao G, Xu L, Skapek SX, Murray MM, Amatruda JF, Klosterkemper L, Shaikh F, Faure-Conter C, Fresneau B, Volchenboum SL, Stoneham S, Lopes LF, Nicholson J, Frazier AL, Xie Y. JCO Clin Cancer Inform 2020 Jun 4():555-566. PMID:32568554
Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma Cells.
Zheng Y, Xu L, Hassan M, Zhou X, Zhou Q, Rakheja D, Skapek SX. Mol Cancer Res 2020 Mar 18(3):364-374. PMID:31757836
Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model.
Sung CY, Liu YT, Bennett LB, Devitt CC, Skapek SX. Mol Biol Rep 2019 Dec 46(6):6243-6252. PMID:31583563
Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib.
Hassan M, Butler E, Wilson R, Roy A, Zheng Y, Liem P, Rakheja D, Pavlick D, Young LL, Rosenzweig M, Erlich R, Ali SM, Leavey PJ, Parsons DW, Skapek SX, Laetsch TW. Cold Spring Harb Mol Case Stud 2019 Oct 5(5):. PMID:31645346
Identification of De Novo Enhancers Activated by TGFß to Drive Expression of CDKN2A and B in HeLa Cells.
Liu YT, Xu L, Bennett L, Hooks JC, Liu J, Zhou Q, Liem P, Zheng Y, Skapek SX. Mol Cancer Res 2019 Sep 17(9):1854-1866. PMID:31189690
Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding.
Li S, Chen K, Zhang Y, Barnes SD, Jaichander P, Zheng Y, Hassan M, Malladi VS, Skapek SX, Xu L, Bassel-Duby R, Olson EN, Liu N. Genes Dev 2019 Jun 1 33(11/12/2022):626-640. PMID:30975722
Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.
Xu L, Zheng Y, Liu J, Rakheja D, Singleterry S, Laetsch TW, Shern JF, Khan J, Triche TJ, Hawkins DS, Amatruda JF, Skapek SX. Cell Rep 2018 Jul 3 24(1):238-251. PMID:29972784
PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.
Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF. Elife 2018 Jun 5 7():. PMID:29869612
p19(Arf) limits primary vitreous cell proliferation driven by PDGF-B.
Iqbal NS, Devitt CC, Sung CY, Skapek SX. Exp Eye Res 2016 Apr 145():224-229. PMID:26778750
Negative regulation of initial steps in skeletal myogenesis by mTOR and other kinases.
Wilson RA, Liu J, Xu L, Annis J, Helmig S, Moore G, Timmerman C, Grandori C, Zheng Y, Skapek SX. Sci Rep 2016 Feb 5 6():20376. PMID:26847534