Sweat Lab

The Sweat Lab is jointly directed by Drs. Mason and Yan Sweat. The group focuses on understanding epigenetic regulatory mechanisms controlling the cellular identity programs of atrial (and ventricular) cardiomyocytes. The group’s prior work has shown that genetic perturbations affecting the regulation of cellular identity programs can result in sustained arrhythmias, like atrial fibrillation. The team uses different types of arrhythmia models to uncover molecular and epigenetic mechanisms of arrhythmia, with the overarching goal of defining mechanistic underpinnings of arrhythmias to develop new treatments.