Publications

Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury.

Su D, Krongbaramee T, Swearson S, Sweat Y, Sweat M, Shao F, Eliason S, Amendt BA, 2025 Jan JCI Insight 1 10

TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.

Sweat ME, Shi W, Sweat YY, Li J, Li J, Keating EM, Ponek A, Ma Q, Park C, Trembley MA, Wang Y, Hou C, Bezzerides VJ, Conlon FL, Pu WT, 2025 Aug Circulation

Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.

Oami T, Abtahi S, Shimazui T, Chen CW, Sweat YY, Liang Z, Burd EM, Farris AB, Roland JT, Tsukita S, Ford ML, Turner JR, Coopersmith CM, 2024 Mar Proc Natl Acad Sci U S A 10 121 e2217877121

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.

Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-François L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR, 2023 May Gut 5 72 870-881

Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.

Eliason S, Hong L, Sweat Y, Chalkley C, Cao H, Liu Q, Qi H, Xu H, Zhan F, Amendt BA, 2022 Sep Clin Transl Med 9 12 e1037

Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle.

Srivastava AK, Venkata BS, Sweat YY, Rizzo HR, Jean-François L, Zuo L, Kurgan KW, Moore P, Shashikanth N, Smok I, Sachleben JR, Turner JR, Meredith SC, 2022 Aug Proc Natl Acad Sci U S A 34 119 e2204618119

PTPN2 mutations cause epithelium-intrinsic barrier loss that synergizes with mucosal immune hyperactivation.

Sweat YY, Turner JR, 2021 Sep J Clin Invest 17 131

The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.

Sweat M, Sweat Y, Yu W, Su D, Leonard RJ, Eliason SL, Amendt BA, 2021 Jun Stem Cells 6 39 761-775

miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster.

Sweat Y, Ries RJ, Sweat M, Su D, Shao F, Eliason S, Amendt BA, 2021 Dec Mol Ther Nucleic Acids 26 1148-1158

Gene-environment interaction in molar-incisor hypomineralization.

Bezamat M, Souza JF, Silva FMF, Corrêa EG, Fatturi AL, Brancher JA, Carvalho FM, Cavallari T, Bertolazo L, Machado-Souza C, Koruyucu M, Bayram M, Racic A, Harrison BM, Sweat YY, Letra A, Studen-Pavlovich D, Seymen F, Amendt B, Werneck RI, Costa MC, Modesto A, Vieira AR, 2021 PLoS One 1 16 e0241898

Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions.

Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA, 2020 Nov J Dent Res 12 99 1397-1405

Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers.

Yu W, Sun Z, Sweat Y, Sweat M, Venugopalan SR, Eliason S, Cao H, Paine ML, Amendt BA, 2020 Jun Development 11 147

Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.

Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA, 2020 Feb Dev Biol 2 458 246-256

Ectodermal Organ Development Is Regulated by a microRNA-26b-Lef-1-Wnt Signaling Axis.

Eliason S, Sharp T, Sweat M, Sweat YY, Amendt BA, 2020 Front Physiol 11 780

FoxO6 regulates Hippo signaling and growth of the craniofacial complex.

Sun Z, da Fontoura CSG, Moreno M, Holton NE, Sweat M, Sweat Y, Lee MK, Arbon J, Bidlack FB, Thedens DR, Nopoulos P, Cao H, Eliason S, Weinberg SM, Martin JF, Moreno-Uribe L, Amendt BA, 2018 Oct PLoS Genet 10 14 e1007675

IFN-stimulated P2Y13 protects mice from viral infection by suppressing the cAMP/EPAC1 signaling pathway.

Zhang C, Yan Y, He H, Wang L, Zhang N, Zhang J, Huang H, Wu N, Ren H, Qian M, Liu M, Du B 2018 Aug J Mol Cell Biol

Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-? Production in a P2X7-Dependent Manner.

Zhang C, He H, Wang L, Zhang N, Huang H, Xiong Q, Yan Y, Wu N, Ren H, Han H, Liu M, Qian M, Du B 2017 Jul J. Immunol.

Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.

Zhang N, Huang H, Tan B, Wei Y, Xiong Q, Yan Y, Hou L, Wu N, Siwko S, Cimarelli A, Xu J, Han H, Qian M, Liu M, Du B 2017 Aug J. Biol. Chem.

Extracellular UDP and P2Y6 Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-? Production.

Li R, Tan B, Yan Y, Ma X, Zhang N, Zhang Z, Liu M, Qian M, Du B 2014 Sep J. Immunol.

Dr. Yan Sweat's Publications